The Coexistence of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

Kosmalski, Marcin; Ziółkowska, Sylwia; Czarny, Piotr; Szemraj, Janusz; Pietras, Tadeusz

doi:10.3390/jcm11051375

Cited by 25 publications

(21 citation statements)

References 189 publications

(210 reference statements)

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“…Carduus acanthoides anti-diabetic investigations provided similar results in the past [ 27 ]. Aminotransferase levels tend to rise in patients with diabetes and are more common than in the general population [ 28 ]. After the introduction of alloxan in prior research, there was a large rise in the activity of specific enzymes, such as Beta-Glucuronidase, Nacetyl-bet Glucosaminidase, Leucine Aminpeptidase, Lysosomal Acid Phosphates, and Cathepsin D [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Carduus edelbergii Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs

et al. 2022

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Background: Due to the high expense, less effectiveness and more side effects of available synthetic medicine, the researchers and communities are focusing on phyto-based natural bioactive compounds, which are considered safer for the treatment of syndromes and chronic diseases. Aim: The current project was aimed to determine the phytochemicals constituents available in the aerial parts of methanol extract of Carduus edelbergii via GC-MS, fabrication of AuNPs mediated with the mentioned extract; characterization and evaluation of antimicrobial, antioxidant and antidiabetic potency of the synthesized AuNPs. Methods: Confirmation of green synthesis of AuNPs, functional groups responsible for the reduction in Au+, size and crystallinity, morphology and quantity of gold (Au) were carried out by Ultraviolet-Visible (UV-Vis) spectroscopy, Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), X-ray Diffraction (XRD) and dispersive X-ray (EDX), respectively, whereas in vitro antioxidant characteristics were assessed by DPPH and ABTS assays. Wistar albino rats were used to test the anti-diabetic properties of the methanol extract and AuNPs. Results: GC-MS revealed that the diluted methanol extract of Carduus edelbergii consists of about 19 chemical constituents. Among the identified compounds, the 13-Docosenoic acid, methyl ester, (Z)— has the highest concentration (38.16%), followed by 9-Octadecenoic acid, methyl ester, (E)— (15.72%) and n-Hexadecanoic acid (15.07%). Methanol extract and its fabricated nanoparticles showed significant antioxidant and antimicrobial activities. In vivo antidiabetic study revealed a noteworthy (p < 0.05) decline in body weight and HDL and elevated concentration of blood glucose, bilirubin, creatinine, urea, triglyceride, VLDL, LDL, ALP, ALT and AST in diabetic control. The said changes were recovered significantly (p < 0.05) by treatment of diabetic rats with methanol extract (150 and 300 mg/Kg BW) and AuNPs of Carduus edelbergii (5 and 10 mg/Kg BW). Conclusion: The green synthesized AuNPs exhibit significant antioxidant, antimicrobial and antidiabetic characteristics.

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Section: Discussionmentioning

confidence: 99%

Carduus edelbergii Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs

et al. 2022

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“…It is notable that obesity coupled with insulin resistance and type 2 diabetes are common comorbidities that exacerbate the progression of NAFLD in a clinical setting. In the insulin-resistant state, hepatic glucose production and fatty acid uptake are elevated, leading to increased substrates for triglyceride synthesis [40]. The fact that PRR antagonism was unable to alter body weight, fasting blood glucose or glucose handling in HFD-fed mice may suggest that our intervention only targets enzymatic pathways directly involved in lipid synthesis while leaving other clinical aspects of NAFLD pathology unchanged.…”

Section: Discussionmentioning

confidence: 99%

(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease

Gayban

Souza

Cooper

et al. 2022

Preprint

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Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism. Here, we hypothesized that inhibition of the PRR would prevent the development of diet-induced hepatic steatosis and fibrosis. To test our hypothesis, we fed wild-type mice on a C57Bl/6J background either a high-fat diet (HFD; 60% calories from fat) or normal fat diet (NFD; 10% calories from fat) with matching calories for 6 weeks. An 8-week methionine choline-deficient (MCD) diet was used to induce fibrosis in C57BL/6J mice. Two weeks following diet treatment, mice were implanted with a subcutaneous osmotic pump delivering either PRO20, a peptide PRR antagonist, or scrambled peptide (700 ug/kg/d) for 4 or 6 weeks. We found that a 6-week HFD significantly increased liver lipid accumulation, as detected by Oil Red O staining, and liver triglyceride content compared with NFD-fed mice. Importantly, PRO20 treatment significantly reduced hepatic lipid accumulation in HFD-fed mice without affecting body weight or glucose levels. Furthermore, PRR antagonism attenuated HFD-induced steatosis, particularly microvesicular steatosis. In the MCD diet model, the percentage of collagen area detected by Sirius Red staining was reduced in PRO20-treated compared with control mice. PRO20 treatment also significantly decreased levels of liver alanine aminotransferase (ALT), an indicator of liver damage, in MCD-fed mice compared with controls. Mechanistically, we found that PRR antagonism prevented HFD-induced increases in PPARγ and glycerol-3-phosphate acyltransferase 3 expression in the liver. Taken together, our findings establish the mechanism by which PRR regulates lipid metabolism in the liver and suggest the therapeutic potential of PRR antagonism for the treatment of liver steatosis and fibrosis development in NAFLD.

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“…The authors used the logistic regression models on the collected dataset for conducting the study. Kosmalski et al (2022) [33] found that there is an underestimation of the liver disease problem in diabetic people and showed the coexistence of both the diseases. The authors alleged that glucose metabolism disturbances diagnosis is typically not performed in patients having liver disease.…”

Section: Bhowmik Et Al (2018) [26] Studied the Ruralmentioning

confidence: 99%

ETL for disease indicators using brute force rule-based NLP algorithm and metadata exploration

2022

IJATEE

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Healthcare data is generated at an extensive rate every single second making the healthcare data growth an exponential problem. Every type of data related to the health status of an individual is termed as health data that comprises of the clinical metrics together with behavioural, ecological, and economic and social [1] health related information. Data driven health technologies [2−6] are undoubtedly bringing the ground-breaking changes to revitalize the healthcare sector. They can even arrange for assistance in diagnosing and predicting certain diseases with the help of using the diagnostic laboratory test reports [7−10] to deliver the best results. Likewise, this can lead to improved effectiveness and lower the expenditures of carrying out the biochemical tests. The advance in operational proficiency can lead to an improved care. *Author for correspondenceThe several sources of health data consist of hospital records, medical histories of patients, administrative data, results of medical check-ups and examinations, [11] etc. Healthcare data also take account of a massive amount of medical data in the form of electronic medical record (EMR) and electronic health record (EHR). EMR is the subset of EHR [12] and are time and again used interchangeably. For diagnosis and treatment, mostly EMR is used. EHR is digital records of health data that contain a lot beyond EMR. Lab tests and diagnostic procedures are included in the EMRs. A diagnostic report is a set of biochemical tests that provide information regarding a person's health. The collected data having diagnostic labels can benefit in the automatic diagnosis of various diseases. Consequently, it can arrange for a prompt diagnostic reference for doctors other than helping to predict the disease ahead of time.

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The Coexistence of Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus

Cited by 25 publications

References 189 publications

Carduus edelbergii Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs

Carduus edelbergii Rech. f. Mediated Fabrication of Gold Nanoparticles; Characterization and Evaluation of Antimicrobial, Antioxidant and Antidiabetic Potency of the Synthesized AuNPs

(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet–Induced Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease

ETL for disease indicators using brute force rule-based NLP algorithm and metadata exploration

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