The Clinicopathological Significance of P21 and P53 Expression in Esophageal Squamous Cell Carcinoma: An Analysis of 153 Patients

Lam, Alfred King‐Yin; Law, Simon; Tin, L.; Tung, Peter H. M.; Wong, John

doi:10.1111/j.1572-0241.1999.01278.x

Cited by 43 publications

(30 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48,49) Down-regulation of p73 expression decreases the induction of apoptosis and cell cycle arrest through down-regulation of p21 function, 19,20) which may cause cancer cells to become more malignant. 50,51) But, as shown in Table 2, p73 expression was not correlated with various clinicopathological factors relating to esophageal cancer progression or the patient's outcome. This is the first report on p73 expression in esophageal cancers and further studies will be necessary to reach a conclusion concerning the mechanism of down-regulation of p73 expression and the clinicopathological role of p73 expression in esophageal cancers.…”

Section: Discussionmentioning

confidence: 98%

“…In esophageal squamous cell carcinoma, several reports have proposed that no correlation exists between the p53 mutation and loss of p21 expression. [50][51][52] Therefore, another route for the activation of p21 WAF1 independent of the p53 pathway has been suggested. 53) On the other hand, p73 expression has been found to be strongly correlated with p21 expression in recent studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers

et al. 2003

View full text Add to dashboard Cite

The significance of the p73 gene, a homologue of the p53 gene, in esophageal cancers is not fully understood. In order to clarify the role of p73 expression in esophageal cancers, p73 expression was immunohistochemically investigated in 106 surgically resected esophageal cancers and the results were compared with various clinicopathological factors. In normal esophageal epithelium, the expression of p73 was observed only in the nuclei of basal cells. In esophageal cancers, p73 immunoreactivity was observed in all intraepithelial lesions except one cancer, and was reduced with cancer invasion, to 78% and 64% at superficial invasion and deep invasion sites, respectively. However, p73 expression was not correlated with any other clinicopathological factor. The expressions of p53 and p21 were also investigated in esophageal cancer. To evaluate the status of the p53 gene mutation immunohistochemically, two monoclonal antibodies (DO7 and PAb240) were used. There seemed to be an inverse correlation between p73 expression and p53 mutation. Moreover, the expression of p21 was highly correlated with p73 expression irrespective of the p53 mutation status. In human esophageal cancers, p73 expression decreased with increasing degree of tumor invasion, and its decreased expression in local advanced tumor caused down-regulation of p21 expression, which might reflect tumor progression. (Cancer Sci 2003; 94: 612-617) sophageal cancers have relatively high mortality rates, despite recent progress in cancer diagnosis and treatment.1) In Japan, long-term follow-up data of a total 11 642 esophagectomized cases show that the prognosis still remains poor, with a mean 5-year survival rate of approximately 36%, even if the esophagectomy is curative.2) Moreover, lymph node metastasis frequently occurs in esophageal cancers compared with other gastrointestinal malignancies, resulting in a poor outcome even for esophageal cancer patients detected at an early stage. 3,4) About 40% of esophageal carcinomas with submucosal invasion have already metastasized to the lymph node, 3) and only 60% of esophageal cancer patients with submucosal invasion survive for 5 years. 2)Recent advances in molecular biology have elucidated that various oncogenes and tumor suppressor genes are closely related to the development and progression of esophageal carcinomas.5-11) Inactivation of the INK4a locus or p16 is the most frequent genetic abnormality in esophageal cancers and occurs in the majority of esophageal cancers at the early stage of carcinogenesis.12, 13) Loss or down-regulation of p16 expression in esophageal cancers is attributed to genetic changes such as homozygous deletion or point mutation in addition to epigenetic hypermethylation of the gene.11) Amplification of the cyclin D1 gene is also a well-known genetic change in esophageal cancers and its overexpression is closely related with the invasiveness of cancer cells and the patient's outcome. 5,9) Furthermore, p53 gene mutation is detected in more than half of esophageal carcinomas and a large ...

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Several studies have revealed the prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma (11)(12)(13). p21 waf1 overexpression has been reported to be associated with a worse prognosis in bladder (14), ovarian (15), breast (16) and esophageal carcinomas (17,18), and also in oral SCC (19).…”

Section: Introductionmentioning

confidence: 99%

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

et al. 2015

View full text Add to dashboard Cite

Abstract. Esophageal squamous cell carcinoma (SCC) possesses one of the worst prognoses out of the digestive carcinomas. Several studies have suggested that transforming growth factor β receptor type II (TGF-βRII), Smad family member 4 (Smad4) and p21 wild-type p53-activated factor 1 (p21 waf1 ) are associated with esophageal SCC. The aim of the present study was to evaluate the effect of Smad4, TGF-βRII and p21 waf1 in esophageal squamous cancer tissue and the pathological significance of the effect. An immunohistochemical method was used to evaluate the expression levels of Smad4, TGF-βRII and p21 waf1 in specimens of esophageal SCC lesions obtained from 80 patients. It was found that the expression of Smad4, TGF-βRII and p21 waf1 in histologically-classified grade I esophageal SCC, without invasion or lymph node metastasis, was markedly higher compared with grade III esophageal SCC that had invaded into the deep muscular or serous layer and metastasized to the lymph nodes (P<0.05). Analysis of the expression level of Smad4, TGF-βRII and p21 waf1 , as well as the clinical and pathological characteristics of esophageal SCC, revealed that the three proteins may be associated with the carcinogenesis, biological behavior and prognosis of esophageal SCC, parallel to the pathological stage and cell grade.

show abstract

“…Several studies have indicated reduced expression of p21 as an indicator of poor esophageal cancer prognosis [175,176], while others have found no significant correlation [173,177]. Conversly others have claimed that p21 overexpression is correlated with a poorer prognosis [165,178].…”

Section: P21/waf1mentioning

confidence: 99%

Growth Factors, Signal Transduction Pathways, and Tumor Suppressor Genes in Esophageal Cancer

Zare¹,

Moghanibashi²,

Jazii³

2012

Esophageal Cancer - Cell and Molecular Biology, Biomarkers, Nutrition and Treatment

View full text Add to dashboard Cite

The Clinicopathological Significance of P21 and P53 Expression in Esophageal Squamous Cell Carcinoma: An Analysis of 153 Patients

Cited by 43 publications

References 37 publications

Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers

Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

Growth Factors, Signal Transduction Pathways, and Tumor Suppressor Genes in Esophageal Cancer

Contact Info

Product

Resources

About