The clinicopathological features of liponeurocytoma

Abstract

To discuss the clinicopathological features of liponeurocytoma, we retrospectively reviewed three liponeurocytoma cases and compared their immunophenotypes and genotypes with those of similar tumors. Furthermore, we reviewed the literature and compared the similarities and differences between cerebellar and intraventricular liponeurocytomas. Two cerebellar and one intraventricular liponeurocytomas were included in the present study. The liponeurocytomas comprised small tumor cells and lipomatous cells. The tumor cells expressed SYN, MAP-2, and NeuN. One case showed atypical histological features. By reviewing the literature, we found that cerebellar liponeurocytoma tended to be more common in females, whereas the converse was true for intraventricular liponeurocytoma. Compared with cerebellar liponeurocytoma, intraventricular liponeurocytoma was more commonly noted in younger adult patients. A high MIB-1 index (>10%) and incomplete tumor resection might represent adverse prognostic factors in patients with liponeurocytoma. We suggest that 'central liponeurocytoma' should be used to include all putative liponeurocytoma sites. The present study identified several morphological, immunohistochemical, and genetic features that may aid in the differential diagnosis of liponeurocytoma. In addition, surgery should be the preferred treatment, and complete tumor resection should be the goal. Additional cases with long-term follow-up are needed to develop optimal management protocols for liponeurocytoma.

Cerebellar Liponeurocytoma Mimicking Medulloblastoma: Case Report of a Childhood and Literature Review

“…Epidemiology cLNCs are highly uncommon, benign, slow-growing glioneuronal neoplasms of the CNS with a favorable clinical prognosis, but a high likelihood of recurrence (1,9), which develop mainly in the adult population. The cerebellar hemisphere is the most common anatomical location for these tumors, followed by the cerebellar vermis, and the tumor can also occur in the supratentorial parenchyma (10,11,(14)(15)(16). Anghileri et al also reported a lumbar metastasis 11 years after the primary surgical excision (14).…”

“…Rosette-like arrangements of tumor cells around the thin vessels were observed in other areas, which had features similar to cellular ependymoma. presented that the Ki-67 index had a tendency to increase after cLNCs recurrence, suggesting tumor progression with a tendency to malignant transformation (3,12,16). Immunostaining provides additional meaningful information that allows for correct diagnosis and differential diagnosis.…”

“…Notably, mild to moderate peritumoral edema was observed in three pediatric patients (3/ 4), with two cases of mild, and one case of moderate surrounding edema. However, peritumoral edema was observed only in 9 adult patients (9/63, [14.3%]) (16,(23)(24)(25)(26)(27)(28)(29)(30), as was mild edema. In some studies, the metabolic activity of cLNCs was evaluated with positron emission tomography (PET) (7,31).…”

Surgical management and clinical outcomes of cerebellar liponeurocytomas-a report of 7 cases and a pooled analysis of individual patient data

“…Histologically, CLPN was composed of monotonous small round tumor cells and lipomatous cells [68]. Mitosis is rare or absent.…”

Cerebellar liponeurocytoma – a rare entity: a case report

“…It shows a monotonous pattern of isomorphic round to oval cells with focal accumulations of lipid-laden cells. The lipomatous cells of the liponeurocytoma seem to be neuroepithelial tumor cells with lipid accumulation or they constitute a form of lipidization instead of true adipose cells [ 7 , 8 ]. In the lipomatous cells, the lipid vacuole membranes were positive for SYN, MAP-2, vimentin, and S-100.…”