The clinical value of proton magnetic resonance spectroscopy in adult brain tumours

Sibtain, Naomi; Howe, Franklyn A.; Saunders, Dawn

doi:10.1016/j.crad.2006.09.012

Cited by 148 publications

(108 citation statements)

References 41 publications

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“…In line with this, cholinecontaining compounds are associated with high cellular proliferation and inflammatory responses in tumor growth and, therefore, choline is often taken as a marker for diagnosis of certain brain tumors (e.g. Kinoshita and Yokota, 1997;Li et al, 2007;Sibtain et al, 2007).…”

Section: Neurotransmitter Metabolismmentioning

confidence: 99%

“…In fact, NAA levels are frequently found to be absent in tumors of glial origin (e.g. Sibtain et al, 2007) and to decrease in neuropathological conditions, correlating with the degree of degeneration in humans (Bruhn et al, 1989;Gideon et al, 1992Gideon et al, , 1994Horská et al, 2009;Kantarci, 2007) and rodents (e.g. Berthet et al, 2011;Lei et al, 2009;Tkáč et al, 2007).…”

Section: Neurotransmitter Metabolismmentioning

confidence: 99%

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The neurochemical profile quantified by in vivo 1H NMR spectroscopy

et al. 2012

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Section: Neurotransmitter Metabolismmentioning

confidence: 99%

Section: Neurotransmitter Metabolismmentioning

confidence: 99%

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

et al. 2012

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“…In vivo 1 H MRS detects a number of tumor phospholipid and bioenergetic metabolites associated with cell proliferation or degradation (9,14,18,19). Phosphorus-31 MR spectra predominantly contain resonances of precursors and catabolites of membrane phospholipids, high-energy phosphates, and inorganic phosphate (17,(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

In Vivo Monitoring Response to Chemotherapy of Human Diffuse Large B-Cell Lymphoma Xenografts in SCID Mice by 1H and 31P MRS

Huang¹,

Nelson²,

Pickup³

et al. 2007

Academic Radiology

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Rationale and Objectives-A reliable non-invasive method for in vivo detection of early therapeutic response of non-Hodgkin's lymphoma (NHL) patients would be of great clinical value. This study evaluates the feasibility of 1 H and 31 P magnetic resonance spectroscopy (MRS) for in vivo detection of response to combination chemotherapy of human diffuse large B-cell lymphoma (DLCL2) xenografts in SCID mice.Materials and Methods. C-ombination chemotherapy with Cyclophosphamide, Hydroxydoxorubicin, Oncovin, Prednisone, and Bryostatin 1 (CHOPB) was administered to tumorbearing SCID mice weekly for up to four cycles. Spectroscopic studies were performed before the initiation of treatment and after each cycle of the CHOPB. Proton MRS for detection of lactate and total choline was performed using a selective multiple-quantum-coherence-transfer (Sel-MQC) and a spin-echo-enhanced Sel-MQC (SEE-Sel-MQC) pulse sequence, respectively. Phosphorus-31 MRS utilizing a non-localized single-pulse sequence without proton decoupling was performed on these animals.Results-Significant decreases in lactate and total choline were detected in the DLCL2 tumors after one cycle of CHOPB chemotherapy. The ratio of phosphomonoesters to β-nucleoside triphosphate (PME/βNTP, measured by 31 P MRS) significantly decreased in the CHOPB treated tumors after two cycles of CHOPB. The control tumors did not exhibit any significant changes in either of these metabolites.Conclusions-This study demonstrates that 1 H MRS and 31 P MRS can detect in vivo therapeutic response of NHL tumors and that lactate and choline offer a number of advantages over PMEs as markers of early therapeutic response.

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“…We had intracranial tumours that include high grade glial tumours (multiform glioblastoma-anaplastic astrocytomas), low-grade glial tumours (gliomatosis serebri-serebelli, ganglio gliomas), meningiomas and metastasis. Except for a metastasis case and two menengiomas, diagnosis of all brain neoplasms neuronal integrity, cell proliferation or degradation, energy metabolism and necrotic transformation of brain or neoplastic tissues (5,6,8,9). Particularly H-MRS is added to the routine brain MRI in order to solve diagnostic problems such as differentiation of neoplastic and non-neoplastic lesions, low and high grade tumours, ischemia from low grade gliomas or discriminating the metastases from primary brain tumours and abcesses (3,5,6,9).…”

mentioning

confidence: 99%

“…Except for a metastasis case and two menengiomas, diagnosis of all brain neoplasms neuronal integrity, cell proliferation or degradation, energy metabolism and necrotic transformation of brain or neoplastic tissues (5,6,8,9). Particularly H-MRS is added to the routine brain MRI in order to solve diagnostic problems such as differentiation of neoplastic and non-neoplastic lesions, low and high grade tumours, ischemia from low grade gliomas or discriminating the metastases from primary brain tumours and abcesses (3,5,6,9). Various spectroscopic methods have been used to study tumour biology, grade gliomas, plan treatment and etc (3,5,6,8).…”

mentioning

confidence: 99%