The Clinical Vagaries of the Herpes Virus

Adrenal Necrosis in Generalized Herpes Simplex

“…due to herpes simplex virus seen at this hospital from 1948 to 1956, a total of 36 cases was found of which approximately the same proportion were seriously ill. There were three deaths, including the case now reported (Brain, 1956). The source of infection is of the greatest importance and, in exactly the same way as efforts are made to avoid bringing eczematous children into contact with vaccinia virus by postponing vaccination, so should the risk of exposure to herpes virus be minimized.…”

“…In symptomatic infections the clinical picture is extremely variable both as regards site of infection and severity (Brain, 1956) and, also, children with eczema are particularly prone to develop a generalized infection due to virus dissemination. This is usually referred to as Kaposi's varicelliform eruption (K.V.E.)…”

Answer to Photo Quiz

“…Eczema herpeticum is generally limited to the skin, but viral dissemination may occur. Prior to the availability of systemic antiviral therapy, the mortality rate associated with this condition was as high as 9% [5]. Treatment with acyclovir (200 mg given p.o.…”

Modern Aids to Diagnosis of Virus Diseases

“…In a series of 38 cases of generalized herpes simplex in children the diagnosis was confirmed by this method in 30 (Brain, 1956). As herpes virus can cause a severe disease in infants and young children, especially those with eczema, early recognition of the aetiology can help to prevent spread to other susceptible children (Dudgeon, 1958).…”