2022
DOI: 10.1111/tan.14613
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Abstract: Immune sensitization, defined as the presence of alloreactive donor‐specific antibodies (DSA), is associated with increased wait‐times and inferior transplant outcomes. Identifying pretransplant DSA with a physical cell‐based assay is critical in defining immunological risk. However, improved solid phase antibody detection has provided the potential to forgo this physical assay. Here, we evaluated the association between DSA mean fluorescence intensity (MFI) and the recently introduced Halifaster Flow cytometr… Show more

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Cited by 1 publication
(2 citation statements)
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“…Despite all of these, the overall performance of B Ly FCXM assay with DSA MFI higher than 1000 was in terms of sensitivity and specificity was 41.94% and 100.00%, respectively. Interestingly, these results are consistent with those reported by other groups using the Halifax protocol 19,20 …”
Section: Resultssupporting
confidence: 93%
See 1 more Smart Citation
“…Despite all of these, the overall performance of B Ly FCXM assay with DSA MFI higher than 1000 was in terms of sensitivity and specificity was 41.94% and 100.00%, respectively. Interestingly, these results are consistent with those reported by other groups using the Halifax protocol 19,20 …”
Section: Resultssupporting
confidence: 93%
“…Interestingly, these results are consistent with those reported by other groups using the Halifax protocol. 19,20 However, there is some inconsistency in research regarding their expression levels: some studies indicate that these antigens are more prominently expressed on B lymphocytes compared to T lymphocytes. Therefore, in the presence of HLA-class I antibodies, a T+B+ Flow Cytometry Crossmatch (FCXM) result is more likely than a T+BÀ result.…”
Section: Resultsmentioning
confidence: 99%