The Clinical Spectrum of Echo-Virus Infection

Jp, Sanford; Se, Sulkin

doi:10.1056/nejm195911262612206

Cited by 43 publications

(6 citation statements)

References 56 publications

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“…There were no other similar cases in the family circles involved, many of those at risk already having had rubella. This is well illustrated in the case of Baby C. Five people lived in the house, all of whom had had rubella in the past, and none of these developed a rash, as would have been expected had the illness been due to one of the enteroviruses (Sanford and Sulkin, 1959).…”

Section: Differential Diagnosismentioning

confidence: 78%

Rubella in the Newborn

McCracken¹

1963

BMJ

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Section: Differential Diagnosismentioning

confidence: 78%

Rubella in the Newborn

McCracken¹

1963

BMJ

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“…There have been many descriptions of outbreaks of viral meningitis, enteritis and encephalitis due to this virus (Sandford & Sulkin, 1959;Karzon, Barron, Winkelstein & Cohen, 1956;Davis & Melnick, 1956). A surprising feature in this nursery is that in spite of the rapid infection of new arrivals, particularly by echovirus 6, in only one instance could an illness be associated with a virus, in this case echovirus 6.…”

Section: Discussionmentioning

confidence: 96%

The feeding of oral poliovirus vaccine to a closed community excreting faecal viruses

Gardner

Cooper

1964

J. Hyg.

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The residential home was investigated to study the endemic virus population. During this study, oral poliovirus vaccine was given to the children and the effect of vaccination on endemic enteroviruses and adenoviruses was investigated. In the light of these findings, the problem of virus interference is discussed. The health of the children is related to their virus infections.We are indebted to Prof. S. D. M. Court and Prof. C. A. Green for the active interest they have taken in this investigation; to Miss J. McQuillin, B.Sc., F.I.M.L.T., for her technical assistance; also to the matron of the home and her staff for their co-operation in supplying the specimens, and to Mr L. J. Whitlock of the Royal Victoria Infirmary and his staff for arranging their transport to the laboratory.

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“…Furthermore, their diagnosis rests on a single neutralization antibody titer to echovirus 6 of 1 : 100 obtained on the ninth day of illness. Other reviews do not mention arthritis as a feature of echovirus illness (1)(2)(3)(4)(12)(13)(14). Viral synovitis is generally considered to occur from either direct synovial involvement' or circulating and local immune complexes (17), as proposed for hepatitis B (18).…”

Section: Discussionmentioning

confidence: 99%

Echovirus‐associated polyarthritis. report of a case with synovial fluid and synovial histologic characterization

1978

Arthritis & Rheumatism

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A patient with fever, myalgias, and acute polyarthritis in whom echovirus 9 was isolated from throat and rectal swab specimens is described. All symptoms resolved spontaneously over a one week period except for the arthritis which required three months for complete recovery. A mildly inflammatory synovial fluid and histologic picture were observed. Attempts to isolate the virus from synovial fluid and synovium during acute illness were unsuccessful.Although echoviruses are recognized producers of a wide spectrum of human illness, arthritis is generally not considered part of this spectrum (1-3), or at most is an exceedingly rare occurrence in echovirus infections (43). Only one weakly documented case of acute arthritis attributed to echovirus is reported in the English language literature (4). A second case documented by viral isolation is reported here and presents the hitherto undescribed synovial fluid and synovial histologic findings. CASE REPORTA 35-year-old female bookkeeper was admitted to the Hospital of the University of Pennsylvania on July 18, 1970 with complaints of fever and myalgias. On July 15, the patient awoke with a painful right shoulder. By evening, chills, fever, and myalgias had developed coincident with marked neck stiffness and pain in both shoulders and the right arm. The shoulders, elbows, ankles, and right metatarsophalangeal (MTP) joints became painful with conspicuous swelling of the knees, ankles, and right MTP joints. The patient was prescribed phenylbutazone by her local physician but noted no symptomatic relief. She denied cough, coryza, sore throat, conjunctivitis, alopecia, mouth ulcers, jaundice, pruritis, Raynaud's phenomenon, nausea, vomiting, abdominal discomfort, or vaginal discharge. The day prior to admission, she noted three small evanescent erythematous skin lesions on her arms. There was no past or family history of rheumatic fever or joint disease. The patient denied recent immunizations or exposure to jaundiced or otherwise ill persons.On admission, she was alert but in obvious distress from painful joints and was unable to walk. Her oral temperature was 39°C (102°F). N o skin eruptions or adenopathy were noted. There was conspicious nuchal rigidity with painful limitation of neck motion. The mandible was tender with painful temporomandibular joint limitation of motion. Diminished right shoulder range of motion without effusion was present. Erythema and tenderness over the left ulnar styloid without wrist effusion were noted. Bilateral non-erythematous relatively non-tender knee effusions were evident, The medial aspect of the left ankle was erythematous, swollen, and tender. The right ankle was tender and swollen with limitation of motion, but was not erythematous. The right first, second, and third MTP joints were hot, erythematous, swollen, and exquisitely tender. No tenosynovitis was present.Laboratory studies revealed a hematocrit of 37 and a leukocyte count of 13,600/mmS with 81% neutrophils and 19%

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The Clinical Spectrum of Echo-Virus Infection

Cited by 43 publications

References 56 publications

Rubella in the Newborn

Rubella in the Newborn

The feeding of oral poliovirus vaccine to a closed community excreting faecal viruses

Echovirus‐associated polyarthritis. report of a case with synovial fluid and synovial histologic characterization

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