The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis

Verberg, M.F.G.; Eijkemans, Marinus J.C.; Macklon, Nick S.; Heijnen, Esther; Baart, Esther B.; Hohmann, Femke; Fauser, Bart C.J.M.; Broekmans, Frank J.

doi:10.1093/humupd/dmn053

Cited by 190 publications

(134 citation statements)

References 45 publications

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“…This observation agrees with previous studies that reported that the outcome of IVF treatment is not affected by the use of a "mild" stimulation if at least five oocytes are obtained at follicular aspiration [22,23]. Since both stimulation strategies allowed to obtain a similar number of mature oocytes, even the proportion of cycles in which spare embryos and oocytes were available for freezing was similar.…”

Section: Discussionsupporting

confidence: 91%

MILD ovarian stimulation with GnRH-antagonist vs. long protocol with low dose FSH for non-PCO high responders undergoing IVF: a prospective, randomized study including thawing cycles

Casano

Guidetti²,

Patriarca

et al. 2012

J Assist Reprod Genet

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Objective To compare the effectiveness of two stimulation protocols in non-polycystic ovary (PCO) high responders undergoing in vitro fertilization (IVF). Design Prospective randomized trial. Setting A Reproductive Medicine and IVF Unit of a University Hospital and a private IVF Clinic. Methods Four hundred-and-twelve normoovulatory women with good ovarian responsiveness were randomized to receive either the "mild" (FSH 150 IU/day from day 4 of a spontaneous cycle followed by GnRH-antagonist from day 8; n=205) or the "long" (FSH 150 IU/day; n=207) stimulation protocol. The outcome of these two regimens was compared including "fresh" and thawing cycles. Results The total FSH dose and the peak estradiol level were significantly lower in the "mild" protocol, whereas the retrieved oocytes, fertilization rate, number and quality of embryos, pregnancy and implantation rates, cumulative "fresh plus thaw" success rate, and incidence of severe ovarian hyperstimulation syndrome were comparable with the two regimens. Conclusions In young, normoovulatory patients with good ovarian responsiveness undergoing IVF the "mild" stimulation protocol has effectiveness and risks comparable to the "long" protocol with low FSH starting dose, even when thawing cycles are included in the comparison.

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Section: Discussionsupporting

confidence: 91%

MILD ovarian stimulation with GnRH-antagonist vs. long protocol with low dose FSH for non-PCO high responders undergoing IVF: a prospective, randomized study including thawing cycles

Casano

Guidetti²,

Patriarca

et al. 2012

J Assist Reprod Genet

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show abstract

“…Five retrieved oocytes were associated with an ideal ongoing pregnancy rate (67 %) per embryo transfer in patients undergoing a mild stimulation protocol using GnRH-antagonist [49,50]. On the other hand, a development of less than five follicles in a standard stimulation protocol is usually associated with poor outcome related to the low number transferred embryos and high cancellation rate due to the fertilization failure [51].…”

Section: Discussionmentioning

confidence: 99%

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Greco

Litwicka

Arrivi

et al. 2013

J Assist Reprod Genet

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Purpose To evaluate the role of co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last one as an alternative to repetitive single embryo transfer in a fresh modified natural cycle. Methods Thirty-six patients underwent ICSI procedure with three frozen natural oocytes supplemented by a fresh one obtained from the fourth modified natural cycle. Thirty-one controls received at least three consecutive single embryo transfer in a fresh modified natural cycle. Results In the study group the oocyte retrieval, survival and total fertilization rate were 73.0 %, 78.1 %, and 64.5 %, respectively. Fifty-two embryos were transferred in 29 transfers. In the control group the oocyte retrieval and fertilization rate was 77.4 % and 83.7 %, respectively. Fifty single embryo transfers were performed. Of a total 14 pregnancies obtained in the study group 10 were defined as clinical and 4 as abortions. In the control group a total of 8 single clinical pregnancies and 2 miscarriages were encountered. The overall (20.0 % vs 48.2 %) and the clinical (16.0 % vs 34.4 %) pregnancy rate were significantly higher in the study group having cumulative embryo transfer following the oocyte accumulation. Conclusions These data demonstrate that the co-transfer of embryos derived from vitrified oocytes accumulated during the previous modified natural cycles and an embryo developed from the last fresh modified natural cycle assure an excellent clinical outcome with the overall and clinical pregnancy rate significantly higher compared to the repetitive single embryo transfer in a fresh modified natural cycle.

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“…The optimal number of retrieved oocytes depends on the ovarian stimulation regimen (22) . However, age and season both significantly affect the response of oocyte developmental competence to FSH stimulation (23) .…”

Section: Results:-effect Of Xenotransplantation Techniques On Number mentioning

confidence: 99%

Role of Smart Medium Supplemented With Follicular Fluid in in Vitro Maturation for Sheep Immature Oocytes Recovered From Xenotransplanted Ovarian Tissue Cortex.

M.R.Fakhrildin¹,

Al-Behadili²,

OdaSelman.³

2016

IJAR

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The clinical significance of the retrieval of a low number of oocytes following mild ovarian stimulation for IVF: a meta-analysis

Cited by 190 publications

References 45 publications

MILD ovarian stimulation with GnRH-antagonist vs. long protocol with low dose FSH for non-PCO high responders undergoing IVF: a prospective, randomized study including thawing cycles

MILD ovarian stimulation with GnRH-antagonist vs. long protocol with low dose FSH for non-PCO high responders undergoing IVF: a prospective, randomized study including thawing cycles

Accumulation of oocytes from a few modified natural cycles to improve IVF results: a pilot study

Role of Smart Medium Supplemented With Follicular Fluid in in Vitro Maturation for Sheep Immature Oocytes Recovered From Xenotransplanted Ovarian Tissue Cortex.

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