The clinical impact of self‐reported symptoms of chronic rhinosinusitis in people with bronchiectasis

Abstract

Background: Chronic rhinosinusitis affects 62% of adults with bronchiectasis and is linked to greater bronchiectasis severity. However, the impact of symptoms of chronic rhinosinusitis on disease-specific and cough-related quality of life is unknown. Methods:In this cross-sectional study, adults with stable bronchiectasis and chronic rhinosinusitis symptoms completed the sinonasal outcome test-22 (SNOT-22), quality of life-bronchiectasis questionnaire, and Leicester cough questionnaire. Bronchiectasis severity was assessed using the bronchiectasis severity index (BSI) and chest high-resolution computed tomography (HRCT).Results: Sixty participants with bronchiectasis (mean [SD] forced expiratory volume in 1 s of 73.2 [25.5] %predicted) were included. Greater severity of chronic rhinosinusitis symptoms (based on SNOT-22) was moderately associated with impaired cough-related quality of life (according to the Leicester cough questionnaire; all r > −.60) and impaired bronchiectasis-specific quality of life (based on the quality of life-bronchiectasis questionnaire), with impaired physical function (r = −.518), less vitality (r = −.631), reduced social function (r = −.546), greater treatment burden (r = −.411), and increased severity of respiratory symptoms (r = −.534). Chronic rhinosinusitis symptoms were unrelated to disease severity according to the BSI (r = .135) and HRCT scoring (all r < .200). The severity of chronic rhinosinusitis symptoms was not affected by sputum color (p = .417) or the presence of Pseudomonas aeruginosa colonization (p = .73). Conclusions: In adults with bronchiectasis, chronic rhinosinusitis has a consistent and negative impact on both cough-related and bronchiectasisspecific quality of life.

YES‐associated protein‐regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps

“…It imposes a significant economic burden and negatively impacts the quality of life of patients 2,3 . For example, CRS has been shown to have a consistent negative impact on cough‐related quality of life and bronchiectasis‐specific quality of life 4 . CRS can be divided into two phenotypes based on different clinical characteristics: CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP) 5 .…”

“… 2 , 3 For example, CRS has been shown to have a consistent negative impact on cough‐related quality of life and bronchiectasis‐specific quality of life. 4 CRS can be divided into two phenotypes based on different clinical characteristics: CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). 5 Though CRSsNP is more common among patients, standard therapy has greatly improved patient quality of life.…”