The clinical correlates of participation levels in people with multiple sclerosis

Abstract

BACKGROUND: Multiple sclerosis (MS) has a huge impact on patients and affects their ability to participate in meaningful activities. OBJECTIVE: To identify motor and non-motor factors that are associated with the participation level in instrumental activities of daily living (IADL), leisure, social and religious activities in people with MS. METHOD: This is a cross-sectional study conducted on 110 individuals with MS. The used outcome measures are: Arabic version of the Activity Card Sort, Berg Balance Scale, Modified Fatigue Impact Scale, Nine Hole Peg Test, 6-Minute Walk Test, Brief International Cognitive Assessment for Multiple Sclerosis, Stroop test and Hospital Anxiety and Depression Scale. RESULTS: Hand function, balance, gender and cognitive status can predict the participation in IADL (R2 = 0.425, P < 0.0001); depression, age, and cognitive status can predict the participation in leisure activities (R2 = 0.372, P < 0.0001), and fatigue, balance and cognitive status can predict social activities participation (R2 = 0.492, P < 0.000). CONCLUSION: Balance, cognition and fatigue affect the level of participation in instrumental activities of daily living, leisure, and religious and social activities.

Resilience, mental health, sleep, and smoking mediate pathways between lifetime stressors and Multiple Sclerosis severity

“…Fatigue is highly debilitating, affects around 80% of PwMS, and is a leading cause of diminished quality of life and reduced social participation 67,68 . Despite its impact, existing interventions to treat fatigue are only modestly to moderately effective for a subset of individuals, making the identification of treatable secondary contributors a high priority.…”

Cognitive decline assessment in speakers of understudied languages

“…MoCA and a score of < 7 on the Instrumental Activities of Daily Living Scale (Table 3) to diagnose dementia based on the published cutoff score from Nasreddine et al 61 Some studies reported data-driven (e.g., regression-based) cutoffs. 45,60,62,63 The participants' age varied considerably across studies ( -The CDR fails to detect frontotemporal dementia.…”

“…For instance, Khatib et al 52 applied a score of ≤ 24.5 on MoCA for dementia detection based on receiver operating characteristic curve derived from the study sample, while Assaf et al 51 used a combined score of ≤ 26 on MoCA and a score of < 7 on the Instrumental Activities of Daily Living Scale (Table 3) to diagnose dementia based on the published cutoff score from Nasreddine et al 61 . Some studies reported data‐driven (e.g., regression‐based) cutoffs 45,60,62,63 …”

Evaluation of the Psychometric Properties of the Health Assessment Questionnaire (HAQ) in a Population of Individuals With Multiple Sclerosis

“…Thus, these symptoms have an important impact on the ability to participate in meaningful activities with repercussions on individuals and societies ( 2 – 4 ). Overall, participation is defined as the “involvement in a life situation,” which includes daily activities, leisure, social activities, and work ( 5 , 6 ). Participation is associated with life quality, self-efficacy, and self-esteem and has been proposed as a determinant of health status.…”

“…Participation is associated with life quality, self-efficacy, and self-esteem and has been proposed as a determinant of health status. Thus, currently, the rehabilitation process tends to focus on improving the participation level among patients ( 6 ). When a person with MS starts a rehabilitation process, it is essential to identify the needs, based not only on the symptoms but also on the difficulties encountered in daily life.…”