The clinical characteristics of AQP4 antibody positive NMO/SD in a large cohort of Chinese Han patients

ZhangBao, Jingzi; Zhou, Lei; Li, Xiaoyang; Cai, Tongjia; Lu, Jiahong; Lü, Chuan-Zhen; Zhao, Chongbo; Quan, Chao

doi:10.1016/j.jneuroim.2016.11.010

Cited by 31 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this cross-sectional study, 27 patients with NMOSD were enrolled from The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China. In our study population, all of the NMOSD patients were females, which is consistent with the known prevalence of this disease among males and females (17,18). Thirty-one age-and gender-matched healthy participants, who were all working staff from The Affiliated Eye Hospital of Wenzhou Medical University, were enrolled as the healthy control (HC) group.…”

Section: Study Populationsupporting

confidence: 58%

The Detection of Retina Microvascular Density in Subclinical Aquaporin-4 Antibody Seropositive Neuromyelitis Optica Spectrum Disorders

et al. 2020

View full text Add to dashboard Cite

Purpose: To use optical coherence tomography (OCT) and OCT angiography (OCT-A) to measure changes in the retinal structure and microvasculature of patients with aquaporin-4 antibody-positive, neuromyelitis optica spectrum disorder (NMOSD) with a history of optic neuritis (NMOSD+ON) and those without it (NMOSD-ON). Methods: A total of 27 aquaporin-4 antibody-positive NMOSD patients and 31 age-and gender-matched healthy control (HC) participants were included. In 27 NMOSD patients, 19 of them had a history of optic neuritis (ON) and 8 of them had no history of ON. Peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell and inner plexiform layer (GCIPL) thickness were measured by OCT. Radial peripapillary capillary density (RPCD) and macular superficial vessel density (MSVD) were measured by OCT-A. Comparisons of retinal structural and microvascular parameters between the cohorts were performed using generalized estimating equation (GEE) models. Diagnostic accuracy was evaluated by the area under the receiver operating characteristics curve (AROC). Results: In NMOSD+ON eyes, the GCIPL and pRNFL thicknesses, 48.6 ± 7.1 and 61.7 ± 25.1 µm, respectively, were significantly thinner than in HC eyes (P < 0.001 for both). However, in NMOSD-ON eyes, the GCIPL and pRNFL thicknesses were not significantly thinner than in HC eyes (P > 0.05 for both). In NMOSD+ON eyes, the RPCD and MSVD, 37.8 ± 7.1 and 36.7 ± 5.0%, respectively, were significantly less dense than HC eyes (P < 0.001 for both). Similarly, the RPCD and MSVD in NMOSD-ON eyes, 49.0 ± 2.8 and 43.9 ± 4.2%, respectively, were also less dense than in HC eyes (P < 0.029 for RPCD, P < 0.023 for MSVD). The highest AROC, 0.845 (sensitivity = 88.5%, specificity = 78.0%), was achieved by the logistic regression combination of all of the variables, i.e., pRNFL, GCIPL, RPCD, and MSVD. Conclusions: Retinal microvascular changes were present in NMOSD-ON eyes. The combination of retinal structural and microvascular parameters might be helpful to discriminate NMOSD-ON eyes from HC eyes.

show abstract

Section: Study Populationsupporting

confidence: 58%

The Detection of Retina Microvascular Density in Subclinical Aquaporin-4 Antibody Seropositive Neuromyelitis Optica Spectrum Disorders

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In patients with AQP4-Abs, the most frequent symptoms at onset are optic neuritis in 37-54% of the patients, and LETM in 30–47% of the patients ( 26 , 63 , 64 ). In patients with MOG-Abs, optic neuritis was the first clinical manifestation in 33–64% whereas myelitis occurred in 18–33% of the patients as initial symptom ( 33 , 48 , 65 ).…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and Treatment of NMO Spectrum Disorder and MOG-Encephalomyelitis

et al. 2018

View full text Add to dashboard Cite

Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead to recurrent attacks of optic neuritis, myelitis and/or brainstem syndromes. In some patients with symptoms of NMOSD, no AQP4-Abs but Abs against myelin-oligodendrocyte-glycoprotein (MOG) are detectable. These clinical syndromes are now frequently referred to as “MOG-encephalomyelitis” (MOG-EM). Here we give an overview on current recommendations concerning diagnosis of NMOSD and MOG-EM. These include antibody and further laboratory testing, MR imaging and optical coherence tomography. We discuss therapeutic options of acute attacks as well as longterm immunosuppressive treatment, including azathioprine, rituximab, and immunoglobulins.

show abstract

“…Studies investigating the clinical characteristics of NMOSD have been conducted in several countries, including China, 6 Denmark, 7 France, 8 Germany, 9 Iran, 10 Japan, 11,12 Korea, 13 Spain, 14 Thailand, 15 Turkey, 16 and United Kingdom. 11 However, it is difficult to compare the clinical features between races using the results of these studies because of variability in inclusion criteria, patient selection methods/criteria, and characteristics investigated, and mixed racial groups.…”

mentioning

confidence: 99%

Racial differences in neuromyelitis optica spectrum disorder

et al. 2018

View full text Add to dashboard Cite

ObjectiveWe aimed to evaluate racial differences in the clinical features of neuromyelitis optica spectrum disorder.MethodsThis retrospective review included 603 patients (304 Asian, 207 Caucasian, and 92 Afro-American/Afro-European), who were seropositive for anti–aquaporin-4 antibody, from 6 centers in Denmark, Germany, South Korea, United Kingdom, United States, and Thailand.ResultsMedian disease duration at last follow-up was 8 years (range 0.3–38.4 years). Asian and Afro-American/Afro-European patients had a younger onset age than Caucasian patients (mean 36, 33, and 44 years, respectively; p < 0.001). During the disease course, Caucasian patients (23%) had a lower incidence of brain/brainstem involvement than Asian (42%) and Afro-American/Afro-European patients (38%) (p < 0.001). Severe attacks (visual acuity ≤0.1 in at least one eye or Expanded Disability Status Scale score ≥6.0 at nadir) at onset occurred more frequently in Afro-American/Afro-European (58%) than in Asian (46%) and Caucasian (38%) patients (p = 0.005). In the multivariable analysis, older age at onset, higher number of attacks before and after immunosuppressive treatment, but not race, were independent predictors of severe motor disabilities at last follow-up.ConclusionA review of a large international cohort revealed that race affected the clinical phenotype, age at onset, and severity of attacks, but the overall outcome was most dependent on early and effective immunosuppressive treatment.

show abstract

The clinical characteristics of AQP4 antibody positive NMO/SD in a large cohort of Chinese Han patients

Cited by 31 publications

References 20 publications

The Detection of Retina Microvascular Density in Subclinical Aquaporin-4 Antibody Seropositive Neuromyelitis Optica Spectrum Disorders

The Detection of Retina Microvascular Density in Subclinical Aquaporin-4 Antibody Seropositive Neuromyelitis Optica Spectrum Disorders

Diagnosis and Treatment of NMO Spectrum Disorder and MOG-Encephalomyelitis

Racial differences in neuromyelitis optica spectrum disorder

Contact Info

Product

Resources

About