The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling

Prognostic and clinicopathological significance of circular RNA circ-ITCH expression in cancer patients: a meta-analysis

“…For instance, by acting as a sponge for oncogenic miR-214 and miR-17, circ-ITCH signi cantly enhances expression of its ITCH linear isoform via competitive interacting with microRNAs, thereby inactivating Wnt/beta-catenin signaling in various cancers [17,21,[26][27][28]. Meanwhile, circ-ITCH was also reported to act as competitive endogenous RNAs (ceRNAs) of other microRNAs, like microRNA-93-5p, miR-145, to execute its tumor suppressive activity in cervical cancer and ovarian carcinoma, respectively [13,29]. Additionally, circ-ITCH was further found to inhibit tumorigenesis through other mechanism rather than acting as microRNA sponge.…”

“…22, was reported to be lower expressed in several cancers [10]. So far, circ-ITCH has been proved to be implicated in prostate cancer [11,12], ovarian cancer [13][14][15], bladder cancer [16], breast cancer [17], lung cancer [18], gastric cancer [19], hepatocellular carcinoma [20], glioma [21] and multiple myeloma [22]. Although the correlation between circ-ITCH expression and cancer progression has been investigated by these studies above, most individual studies have been limited by inconsistent conclusions or small sample sizes.…”

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

“…Moreover, overexpressed circular RNA-MTO1 suppresses breast cancer cell viability and reverses monastrol resistan [15]. Studies also found that circRNAs regulated the malignant biological behavior of ovarian cancer cells [16]. For example, circEXOC6B and circN4BP2L2 may act as novel prognostic biomarkers in patients with epithelial ovarian cancer [17], circ_0051240 promotes cell proliferation, migration and invasion in ovarian cancer [18], and circ-HIPK3 is an important regulator of ovarian cancer progression [19].…”

Circulating non-coding RNAs in recurrent and metastatic ovarian cancer

“…Surprisingly, the downregulation of miR-145 also played a tumor suppressive role. In this context, Hu et al [186] demonstrated that circ-TCH acted as a ceRNA (competing endogenous RNA) to sponge miR-145, increased the level of the RasGTPase RASA1, and inhibited the malignant progression of OC cells via the circ-ITCH-miR-145-RASA1 axis in vitro and in vivo [186] . Besides, the target mRNA of miR-199a is TGF-β2.…”