2009
DOI: 10.1016/j.freeradbiomed.2008.10.025
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Redox dysregulation in cancer cells represents a chemical vulnerability that can be targeted by prooxidant redox intervention. Dietary constituents that contain an electrophilic Michael acceptor pharmacophore may therefore display promising chemopreventive and chemotherapeutic anti-cancer activity. Here, we demonstrate that the cinnamon-derived dietary Michael acceptor trans-cinnamic aldehyde (CA) impairs melanoma cell proliferation and tumor growth. Feasibility of therapeutic intervention using high doses of … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

2
115
0
5

Year Published

2009
2009
2021
2021

Publication Types

Select...
7
1
1

Relationship

1
8

Authors

Journals

citations
Cited by 158 publications
(122 citation statements)
references
References 52 publications
2
115
0
5
Order By: Relevance
“…8B-47) (323), dimethylfumarate (225), inuviscolide (299), and cinnamic aldehyde (Fig. 8C-50) (47). Generally, Michael acceptors target thiol-group containing reaction partners through covalent adduction (thioalkylation), and Michael acceptor-induced redox alterations in target cells can therefore originate from glutathione adduction and ROS formation downstream of glutathione depletion.…”
Section: G Electrophilic Michael Acceptors: Parthenolide and Neratinibmentioning
confidence: 99%
“…8B-47) (323), dimethylfumarate (225), inuviscolide (299), and cinnamic aldehyde (Fig. 8C-50) (47). Generally, Michael acceptors target thiol-group containing reaction partners through covalent adduction (thioalkylation), and Michael acceptor-induced redox alterations in target cells can therefore originate from glutathione adduction and ROS formation downstream of glutathione depletion.…”
Section: G Electrophilic Michael Acceptors: Parthenolide and Neratinibmentioning
confidence: 99%
“…1). Cinnamaldehyde, a major component of cinnamon tree, has been known to induce intracellular ROS generation, leading to apoptotic cell death 21,22 . Cinnamaldehyde contains active Michael acceptor pharmacophore and is given the Generally Recognized as Safe status with approval for use in food in the United States 22 .…”
mentioning
confidence: 99%
“…Cinnamaldehyde, a major component of cinnamon tree, has been known to induce intracellular ROS generation, leading to apoptotic cell death 21,22 . Cinnamaldehyde contains active Michael acceptor pharmacophore and is given the Generally Recognized as Safe status with approval for use in food in the United States 22 . Cinnamaldehyde has been reported to induce ROS generation mainly in the mitochondria and inhibit growth of human cancer cells, but minimal cytotoxicity to normal cells 21,23,24 .…”
mentioning
confidence: 99%
“…Owing to its typical odor and low toxicity to human exposure, cinnamaldehyde is used as food flavoring agent. It is also used as a fungicide, insecticide for mosquito larvae (Cheng et al, 2004) and has shown inhibitory activities towards proliferation, invasion and tumor growth in a murin A375 model of human melanoma (Cabello et al, 2009). Importantly, 70 and its derivatives have shown enormous potential as antimicrobial agents.…”
Section: Cinnamaldehyde Derivatives As Anti-tb Agentsmentioning
confidence: 99%