The choleretic effect of iodipamide.

Feld, Gregory K.; Loeb, Peter M.; Berk, Robert N.; Wheeler, Henry O.

doi:10.1172/jci107959

Cited by 22 publications

(2 citation statements)

References 15 publications

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“…The average osmolarity of 1 mmole TC, calculated from the slope of the osmolarity vs. TC concentration plot, was found to be 0.93 mosmole. This value is similar to 0.8 mosmole reported by Feld et al (10) for Na TC in dog bile. In addition, 50 m M TC did not affect the osmotic coefficients of Na+, Li+, and choline differently (Figure 7).…”

Section: Effect Of Na+ Li' and C H O L I N E On T H E Osmotic Effesupporting

confidence: 92%

Importance of Solvent Drag and Diffusion in Bile Acid-Dependent Bile Formation: Ion Substitution Studies in Isolated Perfused Rat Liver

Anwer¹,

Hegner²

2007

Hepatology

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Ion substitution studies were carried out in the isolated perfused rat liver to define the importance of solvent drag and diffusion in bile acid-dependent bile formation. Two different methods, namely single injection (20 pmoles) and continuous infusions at 0.4, 0.8, 1.2, and 1.6 pmoles per min taurocholate (TC), were used to determine the bile acid-dependent bile flow (BADF). Both methods gave essentially the same results. Replacement of Na' (146 mM) by 120 or 146 mMLi+ and C1-(127 mM) by 120 mM NOS-increased BADF significantly. On the other hand, replacement of Na' by 120 mM choline and C1-by 120 mM isethionate decreased the BADF. The osmolarity of TC solution was not different when Na' was replaced by 120 mM Li' or choline and TC did not affect the osmotic activity of NaCl, LiC1, and choline-Cl differently. Thus, the observed effect of Na' replacement on BADF is not due to any change in the osmotic activity of the secreted TC. Substitution of HC03-by equimolar tricine also decreased BADF. Under this condition, BADF increased when NaCl was replaced by equimolar N d 0 3 . Thus, HCO3-does not seem to be essential for TC choleresis. Since Li+ and Nos-are more permeable, and choline and isethionate are less permeable than Na+ and C1-, respectively, these results suggest that the BADF is dependent on the permeability of the substituting cations and anions and thus support the hypothesis that solvent drag and diffusion play an important role in BADF.

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Section: Effect Of Na+ Li' and C H O L I N E On T H E Osmotic Effesupporting

confidence: 92%

Importance of Solvent Drag and Diffusion in Bile Acid-Dependent Bile Formation: Ion Substitution Studies in Isolated Perfused Rat Liver

Anwer¹,

Hegner²

2007

Hepatology

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“…Second, when the synthetically prepared 3-glucuronide was infused into the biliary fistula rat, it did not induce a true hypercholeresis, if hypercholeresis is defined as a bile flow much too great to be explained by the osmotic effect of recovered bile acids and associated with an enrichment in bicarbonate concentration above that of plasma. The synthetic glucuronide, which is a di-anionic compound, had a choleretic activity of 25 p.Vumo1, quite similar to that of several other dianionic compounds (2 1 kl/compound; 7 kl/ion) (33)(34)(35)(36)(37)(38). Furthermore, the bicarbonate concentration of bile did not increase.…”

Section: Discussionmentioning

confidence: 73%

Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids

et al. 1991

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Using the isolated perfused rat and hamster liver, the relationship between bile flow, bile acid secretion rate and bile acid biotransformation after the injection of a small, bolus dose of radioactive ursodeoxycholate or of its C23 homolog, norursodeoxycholate, was examined. Ursodeoxycholate was promptly secreted into bile mostly as amino acid conjugates; less than 3% was secreted in unchanged form in the rat and less than 2% in the hamster. In contrast, norursodeoxycholate was secreted slowly, and biotransformed into glucuronide conjugates and unconjugated trihydroxy derivatives; it was also secreted in part in unchanged form. In the rat, 7% was secreted in unconjugated trihydroxy derivatives and 3% in unchanged form; in the hamster, 7% was secreted as unconjugated trihydroxy derivatives and 4% in unchanged form. The secreted bile acid species that showed the highest correlation with bile flow by far was always the unconjugated form in both rat and hamster. By multiple regression analysis, the apparent choleretic activity (microliters of induced bile flow per micromoles recovered bile acid molecules) indicated marked hypercholeresis for the unconjugated bile acid marked hypercholeresis for the unconjugated bile acid with values ranging from 100 to 300 microliters/mumol. Bile flow also correlated with total bile acid recovery for ursodeoxycholate in rat and norursodeoxycholate in hamster, but in all studies the apparent choleretic activity was far lower. Other calculations indicated that most bile flow during the first 30 min was induced by secretion of the unconjugated bile acid species in all experiments, the proportion ranging from 50% to 90%. The results indicate that when a bolus of ursodeoxycholate or norursodeoxycholate is presented to the perfused rodent liver, the secretion of the unchanged bile acid appears to be responsible for most of the bile flow, probably by a cholehepatic shunting mechanism.

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Hypercholeretic bile acids: A clue to the mechanism?

Erlinger

1990

Hepatology

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The choleretic effect of iodipamide.

Cited by 22 publications

References 15 publications

Importance of Solvent Drag and Diffusion in Bile Acid-Dependent Bile Formation: Ion Substitution Studies in Isolated Perfused Rat Liver

Importance of Solvent Drag and Diffusion in Bile Acid-Dependent Bile Formation: Ion Substitution Studies in Isolated Perfused Rat Liver

Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids

Hypercholeretic bile acids: A clue to the mechanism?

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