Biochemical Pharmacology volume 82, issue 8, P904-914 2011 DOI: 10.1016/j.bcp.2011.06.018 View full text
Tanguy Araud, Sharon Graw, Ralph Berger, Michael Lee, Estele Neveu, Daniel Bertrand, Sherry Leonard

Abstract: The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is a candidate gene for schizophrenia and an important drug target for cognitive deficits in the disorder. Activation of the α7*nAChR, results in opening of the channel and entry of mono- and divalent cations, including Ca++, that presynaptically participates to neurotransmitter release and postsynaptically to down-stream changes in gene expression. Schizophrenic patients have low levels of α7*nAChR, as measured by binding of the ligand [125…

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