The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma

Kyler, Kathryn E.; Jones, Bridgette L.

doi:10.1016/j.jaci.2023.09.037

Cited by 2 publications

(1 citation statement)

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“…The severity and control of asthma may be connected with increased Th2 and Th17 cell responses and decreased Treg cells in patients [54]. IL-6 is a cytokine synthesized and secreted by various cell types, including Th2 cells, and can be both proinflammatory and anti-inflammatory [55]. TNF-α is considered a pro-inflammatory cytokine associated primarily with Th1-type reactions involved in allergic respiratory responses [56,57].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice

Wang,

He,

Dang

et al. 2024

Foods

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Asthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential mechanism therein. Asthma model mice were constructed by OVA treatment, and kynurenine (KYN), indole-3-lactic acid (ILA), in-dole-3-carbaldehyde (I3C), and indole acetic acid (IAA) were administered by intraperitoneal injection. The percent survival, weight and asthma symptom score of mice were recorded. The total immunoglobulin E and OVA-specific (s)IgE in the serum and the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) were detected by the corresponding ELISA kits. The composition of the gut microbiota and tryptophan-targeted metabolism in mouse feces were analyzed using 16S rRNA gene sequencing and targeted metabolomics, respectively. The four tryptophan metabolites improved the percent survival, weight and asthma symptoms of mice, and reduced the inflammatory cells in lung tissues, especially I3C. I3C and IAA significantly (p < 0.05) downregulated the levels of OVA-IgE and inflammatory cytokines. KYN was observed to help restore gut microbiota diversity. Additionally, I3C, KYN, and ILA increased the relative abundance of Anaeroplasma, Akkermansia, and Ruminococcus_1, respectively, which were connected with tryptophan metabolic pathways. IAA also enhanced capability of tryptophan metabolism by the gut microbiota, restoring tryptophan metabolism and increasing production of other tryptophan metabolites. These findings suggest that tryptophan metabolites may modulate asthma through the gut microbiota, offering potential benefits for clinical asthma management.

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Section: Discussionmentioning

confidence: 99%