Biochemical Pharmacology volume 78, issue 3, P217-223 2009 DOI: 10.1016/j.bcp.2009.02.015 View full text
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David J. Triggle

Abstract: Chemical space whether defined by small molecules or large proteins is larger than can be usefully explored. One of the challenges of drug discovery is thus the definition of the overlap between chemical space, biologically useful space and pharmacological space and how this may be employed in the discovery of new small molecule drugs. Despite the decrease in drug discovery productivity in recent years there is no shortage of targets for small molecule intervention, including stroke, pain, neurodegenerative di…

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