The changing anatomic position of squamous cell carcinoma of the lung – a new conundrum

Krimsky, William; Muganlinskaya, Nargiz; Sarkar, Saiyad; Vulchi, Manasa; Patel, Pujan; Rao, Shiavax J.; Hammer, J; Evans, Ruth; Qureshi, Muhammad Fazal Hussain; Harley, Daniel P.

doi:10.3402/jchimp.v6.33299

Cited by 14 publications

(9 citation statements)

References 9 publications

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“…It is well known fact that localization of SCC is predominantly central and about one third of SCC are peripherally located. [ 21 ] However, incidence of peripheral SCC seems to be increasing and referring to recent reports, peripheral SCC is reported up to 40% to 55% of all lung SCC [ 22 – 24 ] in correlation with our study.…”

Section: Discussionsupporting

confidence: 89%

CT findings of basaloid squamous cell carcinoma of the lung in 12 patients

Kim

Han

et al. 2022

Medicine

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Basaloid squamous cell carcinoma (SCC) is very rare subtype of SCC of the lung and it is important to distinguish basaloid to other subtypes of SCCs, since the prognosis of basaloid subtype is considered poorer than that of other non-basaloid subtypes of SCCs. Aim of this study was to assess computed tomography (CT) findings of basaloid SCC of the lung in 12 patients.From January 2016 to April 2021, 12 patients with surgically proven basaloid SCC of the lung were identified. CT findings were analyzed, and the imaging features were compared with histopathologic reports. Clinical and demographic features were also analyzed.Axial location of the tumor was central in 5 patients, while 7 was in peripheral. Of the 7 patients whose tumors were located in the peripheral, margin of the tumor were smooth (n = 2), lobulated (n = 2), or spiculated (n = 3). After contrast injection, net enhancement value ranged from 15.8 to 71.8 HU (median, 36.4 HU). Endobronchial growth were seen in 5 patients and these patients accompanied obstructive pneumonia or atelectasis. Internal profuse necrosis, cavitation, or calcifications were not seen.On CT, basaloid squamous cell presents as solitary nodule or mass with moderate enhancement. Tumor was located either peripheral or central compartment of the lung and cavitation was absent.

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Section: Discussionsupporting

confidence: 89%

CT findings of basaloid squamous cell carcinoma of the lung in 12 patients

Kim

Han

et al. 2022

Medicine

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“…Squamous cell carcinoma (SCC) used to be a representative histological type of centrally-located lung cancer, but recent studies have reported an increase in peripherally-located SCCs. The incidence of peripherally-located SCCs, which was 15-30% around 25 years ago (5,6), increased to nearly 50% of diagnosed or resected SCC cases (7). Previous reports have revealed a difference in clinicopathological features between central-type and peripheral-type SCCs (8,9).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of small‑sized peripheral squamous cell lung cancer

et al. 2019

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Recent advances in imaging technology have enhanced the detection rate of small-sized peripheral lung cancers. The present study aimed to identify the clinicopathological differences between patients with small-sized peripheral squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Patients with lung cancer who underwent radical surgical resection at Gunma University Hospital between July 2007 and October 2012 were retrospectively analyzed. Patients who exhibited small-sized peripheral tumors (pathological size, ≤2 cm) located within the outer-third of the lung field on preoperative computed tomography were enrolled in the present study. A total of 26 patients were diagnosed with SCC and 214 with ADC. The results revealed that patients with SCC exhibited higher rates of pleural invasion, vascular invasion and lymphatic invasion compared with ADC patients. Additionally, the rate of postoperative recurrence was higher in patients with SCC compared with ADC patients. Patients with ADC were subsequently into two groups: Solid ADCs (sADC) and non-solid ADCs (nsADC), which included pure ground glass nodules and part-solid ADCs. The results revealed that the incidence of pleural invasion, vascular invasion and lymphatic invasion, and the rate of postoperative recurrence in patients with sADCs were similar to those with SCC, but were also significantly higher when compared with nsADC patients. The present study concluded that patients with SCC and sADC may not be suitable candidates for sublobar resection, despite exhibiting small tumors that are located in the peripheral lung.

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“…In the literature, the incidence of central of SQCC is well known in many studies including Mizushima et al [15] who found in their study over 235 squamous cell carcinomas that 129 was peripheral and 106 were central and William Krimsky et al [16] found a total of 56 patients were diagnosed with SCC. Of these, 55% (n = 31) had peripheral and 45% (n = 25) had central SCC.…”

Section: Discussionmentioning

confidence: 99%

Role of CT in differentiation between subtypes of lung cancer; is it possible?

2020

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Background Context and purpose: lung cancer is the second in the incidence rate and the first in death rate in the United States of America in 2017. Its treatment depends upon the tumor staging as well as the histological subtype of lung cancer. CT has been the modality of choice for screening as well as diagnosis of lung cancer; however, few studies tried to correlate different CT features of lung cancer to certain pathological subtypes. Our study aims to assess the CT characteristics of the subtypes of bronchogenic carcinoma. Results SQCC shows a higher incidence of central location compared with the rest of the lung cancers (significance level of 50%, p value of 0.5), internal cavitations (significance level of 94.9%, p value of less than 0.05) as well as more frequency of higher stage within the study population, ADC shows significant predilection to peripheral location compared with the rest of the lung cancers (significance level of 94.9%, p value of less than 0.05). Conclusion There is an evident correlation between the MDCT diagnosis of bronchogenic carcinoma and that of histopathology/cytology. The most common types are SQCC and ADC subtypes. The SQCC type of bronchial carcinoma tends to be central with the internal cavitations are common while ADC tends to be peripheral and solid.

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The changing anatomic position of squamous cell carcinoma of the lung – a new conundrum

Cited by 14 publications

References 9 publications

CT findings of basaloid squamous cell carcinoma of the lung in 12 patients

CT findings of basaloid squamous cell carcinoma of the lung in 12 patients

Clinicopathological features of small‑sized peripheral squamous cell lung cancer

Role of CT in differentiation between subtypes of lung cancer; is it possible?

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