The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation

Han, Jae Yun; Cho, Seung‐Sik; Yang, Ji Hye; Kim, Kyu Min; Jang, Chang Ho; Park, Da Eon; Bang, Joon Seok; Jung, Young Suk; Ki, Sung Hwan

doi:10.1016/j.taap.2015.05.015

Cited by 33 publications

(16 citation statements)

References 32 publications

(8 reference statements)

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“…Except MAPKs, many other protein kinases can also regulate the activation of Nrf2/HO-1 pathway, such as phosphoinositide 3-kinase (PI3K) [ 48 ], AMP-activated protein kinase (AMPK) [ 49 ] and protein kinase C (PKCδ) [ 50 ]. Thus, it has to be further investigated whether GHP may regulate the activation of Nrf2 via other signaling to play a protective action against oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Casein Glycomacropeptide Hydrolysates Exert Cytoprotective Effect against Cellular Oxidative Stress by Up-Regulating HO-1 Expression in HepG2 Cells

Chen

et al. 2017

Nutrients

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Oxidative stress is considered as an important mediator in the progression of metabolic disorders. The objective of this study was to investigate the potential hepatoprotective effects and mechanisms of bovine casein glycomacropeptide hydrolysates (GHP) on hydrogen peroxide (H2O2)-induced oxidative damage in HepG2 cells. Results showed that GHP significantly blocked H2O2-induced intracellular reactive oxygen species (ROS) generation and cell viability reduction in a dose-dependent manner. Further, GHP concentration-dependently induced heme oxygenase-1 (HO-1) expression and increased nuclear factor-erythroid 2-related factor 2 (Nrf2) nuclear translocation. Moreover, pretreatment of GHP increased the activation of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2), which were shown to contribute to Nrf2-mediated HO-1 expression. Taken together, GHP protected HepG2 cells from oxidative stress by activation of Nrf2 and HO-1 via p38 MAPK and ERK1/2 signaling pathways. Our findings indicate that bovine casein glycomacropeptide hydrolysates might be a potential ingredient in the treatment of oxidative stress-related disorders and further studies are needed to investigate the protective effects in vivo.

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Section: Discussionmentioning

confidence: 99%

Casein Glycomacropeptide Hydrolysates Exert Cytoprotective Effect against Cellular Oxidative Stress by Up-Regulating HO-1 Expression in HepG2 Cells

Chen

et al. 2017

Nutrients

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“…19 ROS is connected with the metabolism of cells and various oxidative stress diseases. 20 High concentrations of ROS may create cells damage and are related to a series of adverse result for cell, such as inammation, apoptosis, necrosis, and cancer diseases. 21 Interestingly, low concentration of ROS can produce protective enzymes and endogenous antioxidants that regulate the balance of intracellular homeostasis in mammalian cells.…”

Section: Introductionmentioning

confidence: 99%

The protective effects of Shikonin on lipopolysaccharide/d-galactosamine-induced acute liver injury via inhibiting MAPK and NF-κB and activating Nrf2/HO-1 signaling pathways

Tian

Shen

et al. 2017

RSC Adv.

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“…Previous studies have reported that QCT and QCIT are mixed-type inhibitors of XO. [24,25] Although ISO has been recently reported to possess cytoprotective activity, [26] this study is the first to report its XO inhibitory activity.…”

Section: Discussionmentioning

confidence: 66%

Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia

Yoon

Park

et al. 2016

Journal of Pharmacy and Pharmacology

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The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation

Cited by 33 publications

References 32 publications

Casein Glycomacropeptide Hydrolysates Exert Cytoprotective Effect against Cellular Oxidative Stress by Up-Regulating HO-1 Expression in HepG2 Cells

Casein Glycomacropeptide Hydrolysates Exert Cytoprotective Effect against Cellular Oxidative Stress by Up-Regulating HO-1 Expression in HepG2 Cells

The protective effects of Shikonin on lipopolysaccharide/d-galactosamine-induced acute liver injury via inhibiting MAPK and NF-κB and activating Nrf2/HO-1 signaling pathways

Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia

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