The Cerebral Metabolic Landscape in Autism

Resting state EEG abnormalities in autism spectrum disorders

“…This finding is similar to results from multiple fMRI studies that have shown reduced left frontotemporal connectivity during resting state [18,46,120]. These findings parallel those from Horwitz and colleagues [121], who used positron emission tomography to show reduced correlations in glucose metabolism between frontal and other cortical areas in resting adults with ASD. Generalized decreases in frontoparietal and fronto-occipital connectivity have also been reported in ASD during resting fMRI [22,50].…”

Resting state EEG abnormalities in autism spectrum disorders

“…This finding is similar to results from multiple fMRI studies that have shown reduced left frontotemporal connectivity during resting state [18,46,120]. These findings parallel those from Horwitz and colleagues [121], who used positron emission tomography to show reduced correlations in glucose metabolism between frontal and other cortical areas in resting adults with ASD. Generalized decreases in frontoparietal and fronto-occipital connectivity have also been reported in ASD during resting fMRI [22,50].…”

The pathophysiology of restricted repetitive behavior

“…Compared to matched controls, subjects with autism exhibited atypical connectivity patterns between caudate and cortical areas. Atypical fronto-striatal connectivity was also reported by Horwitz et al [204] who assessed regional cerebral metabolic rates for glucose using positron emission tomography. The autistic group showed significantly lower correlations of the thalamus and caudate with frontal and parietal region.…”

Connectivity analysis is essential to understand neurological disorders

“…This phenomenon has been observed with many different connectivity methods, from some of the earliest applications in aging (Horwitz et al, 1986), Parkinson's disease (Grafton et al, 1994) and neurodevelopmental disorders (Horwitz et al, 1988) to more recent fMRI studies (below).…”

Resting state EEG abnormalities in autism spectrum disorders

“…This finding is similar to results from multiple fMRI studies that have shown reduced left frontotemporal connectivity during resting state [18,46,120]. These findings parallel those from Horwitz and colleagues [121], who used positron emission tomography to show reduced correlations in glucose metabolism between frontal and other cortical areas in resting adults with ASD. Generalized decreases in frontoparietal and fronto-occipital connectivity have also been reported in ASD during resting fMRI [22,50].…”

The pathophysiology of restricted repetitive behavior

“…Compared to matched controls, subjects with autism exhibited atypical connectivity patterns between caudate and cortical areas. Atypical fronto-striatal connectivity was also reported by Horwitz et al [204] who assessed regional cerebral metabolic rates for glucose using positron emission tomography. The autistic group showed significantly lower correlations of the thalamus and caudate with frontal and parietal region.…”

Connectivity analysis is essential to understand neurological disorders

“…This phenomenon has been observed with many different connectivity methods, from some of the earliest applications in aging (Horwitz et al, 1986), Parkinson's disease (Grafton et al, 1994) and neurodevelopmental disorders (Horwitz et al, 1988) to more recent fMRI studies (below).…”

Resting state EEG abnormalities in autism spectrum disorders

“…This finding is similar to results from multiple fMRI studies that have shown reduced left frontotemporal connectivity during resting state [18,46,120]. These findings parallel those from Horwitz and colleagues [121], who used positron emission tomography to show reduced correlations in glucose metabolism between frontal and other cortical areas in resting adults with ASD. Generalized decreases in frontoparietal and fronto-occipital connectivity have also been reported in ASD during resting fMRI [22,50].…”

The pathophysiology of restricted repetitive behavior

“…Compared to matched controls, subjects with autism exhibited atypical connectivity patterns between caudate and cortical areas. Atypical fronto-striatal connectivity was also reported by Horwitz et al [204] who assessed regional cerebral metabolic rates for glucose using positron emission tomography. The autistic group showed significantly lower correlations of the thalamus and caudate with frontal and parietal region.…”

Connectivity analysis is essential to understand neurological disorders

“…This phenomenon has been observed with many different connectivity methods, from some of the earliest applications in aging (Horwitz et al, 1986), Parkinson's disease (Grafton et al, 1994) and neurodevelopmental disorders (Horwitz et al, 1988) to more recent fMRI studies (below).…”