The Cerebral Circulation

The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy

“…Histamine.-As it was possible that acetylcholine might cause an increase in epileptic activity by modifying the cerebral blood flow (Wolff, 1929) histamine acid phosphate 0-1 mgm. was injected intravenously in two epileptic patients from whom subclinical attacks were being recorded by e.e.g.…”

“…(3) a change in blood sugar level from adrenal or pancreatic stimulation (Hrubetz, 1937) ; and (4) an alteration in cerebral blood flow, either an increase through cerebral vasodilatation (Wolff, 1929) or decrease through fall in systemic blood pressure (Wolff and Cattell, 1935). Each of these changes, but especially an increase in blood pH or a fall in blood sugar, might increase petit mal activity.…”

The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy

“…Histamine.-As it was possible that acetylcholine might cause an increase in epileptic activity by modifying the cerebral blood flow (Wolff, 1929) histamine acid phosphate 0-1 mgm. was injected intravenously in two epileptic patients from whom subclinical attacks were being recorded by e.e.g.…”

“…(3) a change in blood sugar level from adrenal or pancreatic stimulation (Hrubetz, 1937) ; and (4) an alteration in cerebral blood flow, either an increase through cerebral vasodilatation (Wolff, 1929) or decrease through fall in systemic blood pressure (Wolff and Cattell, 1935). Each of these changes, but especially an increase in blood pH or a fall in blood sugar, might increase petit mal activity.…”

Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: Possible involvement of NOS inhibition

“…Nitric oxide (NO) has been implicated in the genesis of migraine headache beginning with the observations of Wolff (Wolff, 1929). The NO is linked to spontaneous migraine attacks based on the efficacy of a NO synthase (NOS) inhibitor, l-NAME to decrease pain in delayed onset headache.…”

Cholinergic and Purinergic Regulation of Blood Vessels

“…For example, stimulation of vagus nerves causes dilatation of pial arteries [(154, 157, 237); see Ref. (448) for Russian references], and ACh dilates pial arteries and increases cerebral blood flow (422, 431, 681). Furthermore, local application of carbachol leads to pial artery dilatation (422, 598).…”

The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy

“…Histamine.-As it was possible that acetylcholine might cause an increase in epileptic activity by modifying the cerebral blood flow (Wolff, 1929) histamine acid phosphate 0-1 mgm. was injected intravenously in two epileptic patients from whom subclinical attacks were being recorded by e.e.g.…”

“…(3) a change in blood sugar level from adrenal or pancreatic stimulation (Hrubetz, 1937) ; and (4) an alteration in cerebral blood flow, either an increase through cerebral vasodilatation (Wolff, 1929) or decrease through fall in systemic blood pressure (Wolff and Cattell, 1935). Each of these changes, but especially an increase in blood pH or a fall in blood sugar, might increase petit mal activity.…”

Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: Possible involvement of NOS inhibition

“…Nitric oxide (NO) has been implicated in the genesis of migraine headache beginning with the observations of Wolff (Wolff, 1929). The NO is linked to spontaneous migraine attacks based on the efficacy of a NO synthase (NOS) inhibitor, l-NAME to decrease pain in delayed onset headache.…”

Cholinergic and Purinergic Regulation of Blood Vessels

“…For example, stimulation of vagus nerves causes dilatation of pial arteries [(154, 157, 237); see Ref. (448) for Russian references], and ACh dilates pial arteries and increases cerebral blood flow (422, 431, 681). Furthermore, local application of carbachol leads to pial artery dilatation (422, 598).…”

The Effect of Cholin-Like Substances on the Cerebral Electrical Discharges in Epilepsy

“…Histamine.-As it was possible that acetylcholine might cause an increase in epileptic activity by modifying the cerebral blood flow (Wolff, 1929) histamine acid phosphate 0-1 mgm. was injected intravenously in two epileptic patients from whom subclinical attacks were being recorded by e.e.g.…”

“…(3) a change in blood sugar level from adrenal or pancreatic stimulation (Hrubetz, 1937) ; and (4) an alteration in cerebral blood flow, either an increase through cerebral vasodilatation (Wolff, 1929) or decrease through fall in systemic blood pressure (Wolff and Cattell, 1935). Each of these changes, but especially an increase in blood pH or a fall in blood sugar, might increase petit mal activity.…”

Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: Possible involvement of NOS inhibition

“…Nitric oxide (NO) has been implicated in the genesis of migraine headache beginning with the observations of Wolff (Wolff, 1929). The NO is linked to spontaneous migraine attacks based on the efficacy of a NO synthase (NOS) inhibitor, l-NAME to decrease pain in delayed onset headache.…”

Cholinergic and Purinergic Regulation of Blood Vessels

“…For example, stimulation of vagus nerves causes dilatation of pial arteries [(154, 157, 237); see Ref. (448) for Russian references], and ACh dilates pial arteries and increases cerebral blood flow (422, 431, 681). Furthermore, local application of carbachol leads to pial artery dilatation (422, 598).…”