Abstract:GTSE-1 (G 2 and S phase-expressed-1) protein is specifically expressed during S and G 2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G 2 to M transition. Here we report that human GTSE-1 (hGTSE-1) protein can negatively regulate p53 transactivation function, protein levels, and p53-dependent apoptosis. We identified a physical interaction between the C-terminal regulatory domain of p53 and the C-terminal region of hGTSE-1 that is necessary and sufficien… Show more
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