2019
DOI: 10.1073/pnas.1820753116
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which e… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
34
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
9

Relationship

2
7

Authors

Journals

citations
Cited by 32 publications
(34 citation statements)
references
References 29 publications
(41 reference statements)
0
34
0
Order By: Relevance
“…Cyclin-dependent kinases and their cognate cyclins have been shown to have important roles during meiosis and recombination in many organisms (Yang et al;Trovesi et al, 2013;Gómez-Escoda and Wu, 2017;Wijnker et al, 2019). We have previously demonstrated that CDKG1 is necessary for CO formation and homologous chromosome synapsis at high ambient temperature during male meiosis in Arabidopsis (Zheng et al, 2014).…”
Section: Discussionmentioning
confidence: 93%
“…Cyclin-dependent kinases and their cognate cyclins have been shown to have important roles during meiosis and recombination in many organisms (Yang et al;Trovesi et al, 2013;Gómez-Escoda and Wu, 2017;Wijnker et al, 2019). We have previously demonstrated that CDKG1 is necessary for CO formation and homologous chromosome synapsis at high ambient temperature during male meiosis in Arabidopsis (Zheng et al, 2014).…”
Section: Discussionmentioning
confidence: 93%
“…In both cases, loss of CDK activity results in sterility. In Arabidopsis , weak loss-of-function alleles of the CDKA;1 kinase result in severe meiotic defects and the plants being completely sterile ( Dissmeyer et al, 2007 , 2009 ; Wijnker et al, 2019 ). Similar observations have been made using mutants in the cognate cyclins, cyclins CYC1A1;2 (also known as TARDY ASYNCHRONOUS MEIOSIS, TAM) and CYCB3;1 or SOLO DANCERS (SDS; Magnard et al, 2001 ; Azumi et al, 2002 ; Bulankova et al, 2013 ).…”
Section: Discussionmentioning
confidence: 99%
“…The ZMM proteins are required during prophase I for the stabilization of recombination intermediates, and the disruption of this pathway by the loss of function of proteins like MSH4 or MSH5 results in the elimination of class-I COs. Indeed, msh4 and msh5 mutants show on average 1.2 and 1.6 chiasmata per cell during meiosis, respectively, versus the nine to 10 chiasmata formed in wild-type meiosis (Higgins et al, 2004(Higgins et al, , 2008Wijnker et al, 2019). Therefore, in the event that either MSH4 or MSH5 is non-functional, recombinant and non-recombinant chromosomes will segregate at meiosis and both viable and non-viable gametes will be formed (Higgins et al, 2004;Lu et al, 2008).…”
Section: Partial Versus Complete Co Suppressionmentioning
confidence: 99%