The Case Against the Use of Steroids in the Treatment of Bacterial Keratitis

Response to Editorial About the Convergence Insufficiency Treatment Trial

“…Commenting on evisceration more than 40 years ago, Wendell Hughes, MD, stated, "The possibility of the development of sympathetic ophthalmia has been a deterrent to the general acceptance of this procedure, in addition to the remote possibility of missing the diagnosis of an intraocular malignancy in a degenerated globe." 2 We concur that evisceration is a highly successful and safe alternative to enucleation in most instances. Ophthalmic pathologists admittedly have a unique perspective of ophthalmic practice.Oneofthecorrespondingauthor'scolleaguesfrequently reminds him that he "only sees the cases with complications, or the procedures that don't work."…”

Response to Editorial About the Convergence Insufficiency Treatment Trial

“…Commenting on evisceration more than 40 years ago, Wendell Hughes, MD, stated, "The possibility of the development of sympathetic ophthalmia has been a deterrent to the general acceptance of this procedure, in addition to the remote possibility of missing the diagnosis of an intraocular malignancy in a degenerated globe." 2 We concur that evisceration is a highly successful and safe alternative to enucleation in most instances. Ophthalmic pathologists admittedly have a unique perspective of ophthalmic practice.Oneofthecorrespondingauthor'scolleaguesfrequently reminds him that he "only sees the cases with complications, or the procedures that don't work."…”

Nocardia Keratitis: Clinical Course and Effect of Corticosteroids

“…Corticosteroids may reduce inflammation that can lead to ocular damage, however there is a risk that they may exacerbate the infection and cause corneal melting. 17–20 The primary SCUT analysis found no overall difference in safety and efficacy between adjunctive corticosteroid therapy and placebo. 16 The effect of topical corticosteroids on Nocardia spp ulcers has not been previously well characterized.…”

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

“…Ophthalmologists have generally been reluctant to prescribe adjunctive anti-inflammatory drugs, such as corticosteroids, because of their immunosuppressive effects. [40][41][42] Thus, there is significant interest in identifying biologic agents and immunomodulatory therapies that target ocular inflammation without major disruption to the normal immune response in the eye. 33,43 Here, we used an integrated transcriptomic 10 and untargeted metabolomics 11 approach to identify genes and metabolites involved in experimental bacterial endophthalmitis.…”

Response to Editorial About the Convergence Insufficiency Treatment Trial

“…Commenting on evisceration more than 40 years ago, Wendell Hughes, MD, stated, "The possibility of the development of sympathetic ophthalmia has been a deterrent to the general acceptance of this procedure, in addition to the remote possibility of missing the diagnosis of an intraocular malignancy in a degenerated globe." 2 We concur that evisceration is a highly successful and safe alternative to enucleation in most instances. Ophthalmic pathologists admittedly have a unique perspective of ophthalmic practice.Oneofthecorrespondingauthor'scolleaguesfrequently reminds him that he "only sees the cases with complications, or the procedures that don't work."…”

Nocardia Keratitis: Clinical Course and Effect of Corticosteroids

“…Corticosteroids may reduce inflammation that can lead to ocular damage, however there is a risk that they may exacerbate the infection and cause corneal melting. 17–20 The primary SCUT analysis found no overall difference in safety and efficacy between adjunctive corticosteroid therapy and placebo. 16 The effect of topical corticosteroids on Nocardia spp ulcers has not been previously well characterized.…”

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

“…Ophthalmologists have generally been reluctant to prescribe adjunctive anti-inflammatory drugs, such as corticosteroids, because of their immunosuppressive effects. [40][41][42] Thus, there is significant interest in identifying biologic agents and immunomodulatory therapies that target ocular inflammation without major disruption to the normal immune response in the eye. 33,43 Here, we used an integrated transcriptomic 10 and untargeted metabolomics 11 approach to identify genes and metabolites involved in experimental bacterial endophthalmitis.…”

Response to Editorial About the Convergence Insufficiency Treatment Trial

“…Commenting on evisceration more than 40 years ago, Wendell Hughes, MD, stated, "The possibility of the development of sympathetic ophthalmia has been a deterrent to the general acceptance of this procedure, in addition to the remote possibility of missing the diagnosis of an intraocular malignancy in a degenerated globe." 2 We concur that evisceration is a highly successful and safe alternative to enucleation in most instances. Ophthalmic pathologists admittedly have a unique perspective of ophthalmic practice.Oneofthecorrespondingauthor'scolleaguesfrequently reminds him that he "only sees the cases with complications, or the procedures that don't work."…”

Nocardia Keratitis: Clinical Course and Effect of Corticosteroids

“…Corticosteroids may reduce inflammation that can lead to ocular damage, however there is a risk that they may exacerbate the infection and cause corneal melting. 17–20 The primary SCUT analysis found no overall difference in safety and efficacy between adjunctive corticosteroid therapy and placebo. 16 The effect of topical corticosteroids on Nocardia spp ulcers has not been previously well characterized.…”

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

“…Ophthalmologists have generally been reluctant to prescribe adjunctive anti-inflammatory drugs, such as corticosteroids, because of their immunosuppressive effects. [40][41][42] Thus, there is significant interest in identifying biologic agents and immunomodulatory therapies that target ocular inflammation without major disruption to the normal immune response in the eye. 33,43 Here, we used an integrated transcriptomic 10 and untargeted metabolomics 11 approach to identify genes and metabolites involved in experimental bacterial endophthalmitis.…”