The Carney Complex: Unusual Skin Findings and Recurrent Cardiac Myxoma

Bennett, Kenneth R.; Heath, Bobby J.; Creswell, Lawrence L.; Veugelers, Mark; McDermott, Deborah A.; Barksdale, Sarah; Goldstein, Martin; Basson, Craig T.

doi:10.1001/archderm.141.7.916

Cited by 9 publications

(5 citation statements)

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“…316 They are typically found on the eyelids, nipples and buttocks, and in the external ear canals; they are frequently misdiagnosed as fibroepithelial lesions. 317,318 Similar cases have been reported as the NAME or LAMB syndrome (see Ch. 317,318 Similar cases have been reported as the NAME or LAMB syndrome (see Ch.…”

Section: Mucocele Of the Lipsupporting

confidence: 68%

Cutaneous mucinoses

Weedon

2010

Weedon's Skin Pathology

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Section: Mucocele Of the Lipsupporting

confidence: 68%

Cutaneous mucinoses

Weedon

2010

Weedon's Skin Pathology

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“…Eleven years later he was diagnosed with papillary cancer of thyroid, which suggests that all patients should be followed for life [21]. Another report outlines the case of an African-American woman with atypical depigmented skin lesions who had undergone seven heart operations because of the recurrence of myxoma [22]. Our patient had undergone two operations because of cardiac myxoma.…”

Section: Discussionmentioning

confidence: 99%

Carney complex presenting with a unilateral adrenocortical nodule: a case report

et al. 2014

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IntroductionCarney complex is an autosomal dominant syndrome with multiple neoplasms in different sites, including myxomas, endocrine tumors and lentigines lesions. To the best of our knowledge, this is the first report of Carney complex presenting with a unilateral adrenal adenoma associated with a pituitary incidentaloma.Case presentationA 27-year-old Iranian woman was referred to our endocrinology clinic with amenorrhea and hirsutism, further confirming a diagnosis of adrenocorticotropic hormone-independent Cushing’s syndrome. The cause was believed to be a right adrenocortical adenoma based on a computed tomography scan. Our patient underwent a right laparoscopic adrenalectomy and pathological examination revealed pigmented micronodular adrenal hyperplasia. Pituitary magnetic resonance imaging also documented a microadenoma that was considered to be an incidentaloma based on normal pituitary function tests. Recurrence of hypercortisolism led to a left laparoscopic adrenalectomy, providing further evidence for the diagnosis of primary pigmented nodular adrenocortical disease. Carney complex was established in light of her history of cardiac myxomas.ConclusionWe present what we believe to be the first case of Carney complex presenting with a unilateral adrenocortical adenoma in association with a pituitary incidentaloma. Although primary pigmented nodular adrenocortical disease is rare as a component of Carney complex, it should be considered in the differential diagnosis of Cushing's syndrome. Rarely, adrenal and pituitary imaging can be misleading.

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“…17,18 However, only one clinical report of a patient with both vitiligo and CNC has been published. 19 Both CNC loci (2p16 and 17q22-24) may be involved in the same molecular pathway. 18 Major advances have been made towards understanding the genetics of various familial lentiginosis syndromes.…”

Section: Discussionmentioning

confidence: 99%