“…Such a mecha nism has been postulated to explain the dose-dependent distribution of oxotremorine and the absence of this phenomenon if the peripheral cholinergic effect, predomi nantly the profound hypotension, are blocked (38). A similar feedback control of drug uptake and distribution based upon the effects on cardiac output and distribu tion of organ blood flow produced by halothane anesthesia (39) has been investigated (40)(41)(42)(43).…”