The Cardiology of Old Age

Pathogenesis of "senile" nodular sclerosis of atrio-ventricular valves.

“…From the above results it is possible to define a standard for the normal appearances of the atrio-ventricular valves in the aged. Gavey's (1949) criteria for normal heart valves in any age-group as "the least degree of change observed in that group" has been applied. As 44 per cent of hearts, even in the over 85-year group, had only slight mitral valve thickening, and tricuspid thickening was absent in 20 per cent, the normal mitral valve should, therefore, show only slight nodular sclerosis, even in the elderly, and the normal tricuspid valve none.…”

Pathogenesis of "senile" nodular sclerosis of atrio-ventricular valves.

“…From the above results it is possible to define a standard for the normal appearances of the atrio-ventricular valves in the aged. Gavey's (1949) criteria for normal heart valves in any age-group as "the least degree of change observed in that group" has been applied. As 44 per cent of hearts, even in the over 85-year group, had only slight mitral valve thickening, and tricuspid thickening was absent in 20 per cent, the normal mitral valve should, therefore, show only slight nodular sclerosis, even in the elderly, and the normal tricuspid valve none.…”

Ageing changes in human heart valves.

“…The lack of a standard for normal valve thickenhanged very ing, commented on in Rosenthal and Feigin's (1947) t and pliable study on mitral valves in older patients, has been r changes ob-rectified by Gavey (1949). His standard for the of nodular normal valve in any age-group as "the least degree edges of the of change observed in that group" has been used in the present study.…”

“…It seems, therefore, that some degree of damage and endocardial fibrous thickening is an early normal response to the relatively forceful hmmodynamic pressures in the systemic circulation; the lower pressures in the lesser circulation are insufficient to produce similar changes in the right heart valves. Although slight thickening of the anterior mitral cusp is accepted as normal (Rosenthal and Feigin, 1947;Gavey, 1949), greater degrees of atrio-ventricular thickening are not. Together with pulmonary noduli Morgani and mucoid degeneration of mitral valves, they form the intermediate group of changes whose development was largely limited to the middle age-groups.…”

AN APPROACH TO THE TREATMENT OF: Severe Essential Hypertension

“…This holds more particularly for female than for male patients. Patients with malignant hypertension who are in an advanced stage of uræmia. Patients above the age of seventy who do not show evidence of progression regardless of the height of the blood pressure. Extreme levels of hypertension in the aged do not have the prognostic significance that they have in younger individuals 1 …”

Pathogenesis of "senile" nodular sclerosis of atrio-ventricular valves.

“…From the above results it is possible to define a standard for the normal appearances of the atrio-ventricular valves in the aged. Gavey's (1949) criteria for normal heart valves in any age-group as "the least degree of change observed in that group" has been applied. As 44 per cent of hearts, even in the over 85-year group, had only slight mitral valve thickening, and tricuspid thickening was absent in 20 per cent, the normal mitral valve should, therefore, show only slight nodular sclerosis, even in the elderly, and the normal tricuspid valve none.…”

Ageing changes in human heart valves.

“…The lack of a standard for normal valve thickenhanged very ing, commented on in Rosenthal and Feigin's (1947) t and pliable study on mitral valves in older patients, has been r changes ob-rectified by Gavey (1949). His standard for the of nodular normal valve in any age-group as "the least degree edges of the of change observed in that group" has been used in the present study.…”

“…It seems, therefore, that some degree of damage and endocardial fibrous thickening is an early normal response to the relatively forceful hmmodynamic pressures in the systemic circulation; the lower pressures in the lesser circulation are insufficient to produce similar changes in the right heart valves. Although slight thickening of the anterior mitral cusp is accepted as normal (Rosenthal and Feigin, 1947;Gavey, 1949), greater degrees of atrio-ventricular thickening are not. Together with pulmonary noduli Morgani and mucoid degeneration of mitral valves, they form the intermediate group of changes whose development was largely limited to the middle age-groups.…”

AN APPROACH TO THE TREATMENT OF: Severe Essential Hypertension

“…This holds more particularly for female than for male patients. Patients with malignant hypertension who are in an advanced stage of uræmia. Patients above the age of seventy who do not show evidence of progression regardless of the height of the blood pressure. Extreme levels of hypertension in the aged do not have the prognostic significance that they have in younger individuals 1 …”

Pathogenesis of "senile" nodular sclerosis of atrio-ventricular valves.

“…From the above results it is possible to define a standard for the normal appearances of the atrio-ventricular valves in the aged. Gavey's (1949) criteria for normal heart valves in any age-group as "the least degree of change observed in that group" has been applied. As 44 per cent of hearts, even in the over 85-year group, had only slight mitral valve thickening, and tricuspid thickening was absent in 20 per cent, the normal mitral valve should, therefore, show only slight nodular sclerosis, even in the elderly, and the normal tricuspid valve none.…”

Ageing changes in human heart valves.

“…The lack of a standard for normal valve thickenhanged very ing, commented on in Rosenthal and Feigin's (1947) t and pliable study on mitral valves in older patients, has been r changes ob-rectified by Gavey (1949). His standard for the of nodular normal valve in any age-group as "the least degree edges of the of change observed in that group" has been used in the present study.…”

“…It seems, therefore, that some degree of damage and endocardial fibrous thickening is an early normal response to the relatively forceful hmmodynamic pressures in the systemic circulation; the lower pressures in the lesser circulation are insufficient to produce similar changes in the right heart valves. Although slight thickening of the anterior mitral cusp is accepted as normal (Rosenthal and Feigin, 1947;Gavey, 1949), greater degrees of atrio-ventricular thickening are not. Together with pulmonary noduli Morgani and mucoid degeneration of mitral valves, they form the intermediate group of changes whose development was largely limited to the middle age-groups.…”

AN APPROACH TO THE TREATMENT OF: Severe Essential Hypertension

“…This holds more particularly for female than for male patients. Patients with malignant hypertension who are in an advanced stage of uræmia. Patients above the age of seventy who do not show evidence of progression regardless of the height of the blood pressure. Extreme levels of hypertension in the aged do not have the prognostic significance that they have in younger individuals 1 …”