The canine model of human cognitive aging and dementia: Pharmacological validity of the model for assessment of human cognitive-enhancing drugs

Studzinski, Christa M.; Araujo, Joseph A.; Milgram, Norton W.

doi:10.1016/j.pnpbp.2004.12.014

Cited by 85 publications

(62 citation statements)

References 61 publications

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“…Research such as our study has important implications for both human and canine health as dogs are known to develop age-related cognitive dysfunction similar to that seen in humans [39] and dogs have previously been used as a model for the human brain in studies of aging [15][16][17]. Therefore, developments in the understanding of canine brain aging and its treatment could be used to direct similar research in people.…”

Section: Discussionmentioning

confidence: 85%

“…For comparison, we also investigated effects of gonadectomy on cognition, given evidence that gonadectomy can reduce cognitive function [11][12][13][14]. Dogs were chosen as the test subjects both because resveratrol supplements are being promoted for use in dogs as well as humans, and because dogs have been used as a model for the human brain in studies of aging [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Story¹

2012

TONUTRJ

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Abstract:Resveratrol supplements are marketed on the premise they enhance cognitive function. We explored effects of resveratrol supplementation on cognitive function, in the absence of pathology, by assessing effects of resveratrol on the performance of young, healthy, recently gonadectomised dogs in an eight-arm radial maze. Effects of gonadectomy on cognition were also assessed. Performances of untreated intact dogs, resveratrol-treated gonadectomised dogs (60mg/day of resveratrol orally) and placebo-treated gonadectomised dogs were compared in three phases. Dogs received the placebo or resveratrol for two to four weeks before testing began. In phase one, untreated intact (n = 16), resveratrol-treated gonadectomised (n = 6) and placebo-treated gonadectomised dogs (n = 5) were allowed to choose all maze arms they entered. In phase two, untreated intact (n = 15), resveratrol-treated gonadectomised (n = 6) and placebo-treated gonadectomised dogs (n = 5) entered four predetermined arms and then made four free choices from all eight arms. In phase three, a subset of dogs previously tested as untreated intact dogs in phases one and two were tested. In phase three, placebotreated gonadectomised (n = 6) and resveratrol-treated gonadectomised dogs (n = 6) entered seven predetermined arms and then had free choice between a previously opened arm and the unopened arm. Performance in the maze did not differ significantly between gonadectomised dogs receiving the placebo and gonadectomised dogs receiving resveratrol or between untreated intact dogs and gonadectomised dogs receiving the placebo. We conclude that resveratrol treatment does not improve (and gonadectomy does not impair) the aspects of cognitive function that were tested by the radial arm maze trials in young, healthy dogs receiving extensive handling and environmental/behavioural enrichment.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Story¹

2012

TONUTRJ

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“…104 Selegiline, propentofylline and nicergoline have all been used with varying degrees of success. [105][106][107][108] 774 JFMS CLINICAL PRACTICE ✜ CKD may mask hyperthyroidism.…”

Section: Osteoarthritismentioning

confidence: 99%

American Association of Feline Practitioners: Senior Care Guidelines

Pittari¹,

Rodan²,

Beekman³

et al. 2009

Journal of Feline Medicine and Surgery

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Background Cats are the most popular pet in the United States and much of Northern Europe. Although 78% of owners consider their cats to be family members, many cats, particularly seniors, do not receive appropriate preventive care. 1 – 3 One of the main obstacles to owner compliance is the lack of a clear recommendation by the veterinary team. 4 Guidelines can help veterinarians to minimize this obstacle, strengthen the human-pet-veterinary bond, and improve the quality of life of cats. Goals The goals of this article are to assist veterinarians to: Deliver consistent high-quality care to senior cats. Promote longevity and improve the quality of life of senior cats by: recognizing and controlling health risk factors; facilitating and promoting early detection of disease; improving or maintaining residual organ function; and delaying the progression of common conditions. Define aspects of screening, diagnosis, treatment and anesthesia of senior cats.

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“…Although not all the mechanisms by which it produces cognitive improvement are clearly understood, enhancement of dopamine and other neurotransmitters in the cortex and hippocampus is presumed to be a central aspect [99], improving neuronal impulse function and enhancing the learned cognitive function [96,100,101].…”

Section: L-deprenylmentioning

confidence: 99%

Dogs with Cognitive Dysfunction Syndrome: A Natural Model of Alzheimer’s Disease

Bosch¹,

Pugliese²,

Gimeno-Bayón³

et al. 2012

CAR

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In the search for appropriate models for Alzheimer's disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping to elucidate the cascade of events that take place in brain amyloid-beta (Aβ) deposition aging, and cognitive deficit. Recent innovative research has validated human methods and tools for the analysis of canine neuropathology and has allowed the development of two different approaches to investigate dogs as natural models of AD. The first approach relates AD-like neuropathy with the decline in memory and learning ability in aged housed dogs in a highly controlled laboratory environment. The second approach involves research in family-owned animals with cognitive dysfunction syndrome. In this review, we compare the strengths and limitations of housed and family-owned canine models, and appraise their usefulness for deciphering the early mechanisms of AD and developing innovative therapies.KEYWORDS: aging, Amyloid-beta, animal model, canine cognitive dysfunction syndrome, family dog, therapies. 6 Why a canine model of AD?For years, the search for appropriate animal models for Alzheimer's disease (AD) has focused on a variety of manipulations to reproduce the disease in various species, such as yeast, Drosophyla melanogaster, Caenorabditis elegans, rodents, and rabbits, with a particular interest in obtaining knockout and transgenic animals (for a review, see [1]research is currently performed in the mouse because its brain structure is somewhat similar to that of humans, and it is amenable to highly sophisticated genetic engineering. Because age-related cognitive decline is a common feature of most mammals, other laboratories have focused on the few species that naturally develop cognitive dysfunction with various Alzheimer-like characteristics. These animals include the monkey, polar bear, cat and dog [2][3][4][5]. Canine models are currently considered a useful intermediate between genetically modified mouse models and humans [6,7]. Although many of the transgenic AD models have provided insights into the molecular mechanisms of the pathology, none of them encompass all the cognitive deficits observed in AD (see Table 1). One of the first transgenic mouse AD models was the amyloid precursor protein transgenic mouse, PDAPP mouse, which develops age-dependent amyloid beta accumulation and deposition in both diffuse and fibrillar neuritic plaques in the hippocampus, cerebral cortex, and corpus callosum [8]. Other models with AD-like pathology are apolipoprotein E (ApoE) or Tau transgenic mice, and also mice in which other genes have been modified. In more sophisticated approaches, important information has been gained from crossing PDAPP and ApoE models and with mice lacking or over-expressing genes for beta-secretase, alpha-secretase, or the insulin-degrading enzyme [9,10].All these models have provided valuable information on AD pathology and on the poss...

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The canine model of human cognitive aging and dementia: Pharmacological validity of the model for assessment of human cognitive-enhancing drugs

Cited by 85 publications

References 61 publications

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

American Association of Feline Practitioners: Senior Care Guidelines

Dogs with Cognitive Dysfunction Syndrome: A Natural Model of Alzheimer’s Disease

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