The Cancer Preventive Seed Peptide Lunasin From Rye Is Bioavailable and Bioactive

Jeong, Hyung Jin; Lee, Jeong Rak; Jeong, Jin Boo; Park, Jae Ho; Cheong, Young-keun; Lumen, Ben O. de

doi:10.1080/01635580902850082

Cited by 78 publications

(60 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lunasin has been identified in soybean, barley, wheat and rye, and has been subjected to corresponding comparative analysis (24,25). However, due to the genotypic impact of different species, the lunasin content varies between species (26).…”

Section: Characterization Of Lunasinmentioning

confidence: 99%

“…However, due to the genotypic impact of different species, the lunasin content varies between species (26). The lunasin content in soybean, barley, wheat and rye was determined to be between 0.5 and 8.1, between 0.013 and 0.099, between 0.2 and 0.3, and between 0.045 and 0.150 mg/g seed, respectively (14,25,26). Therefore, soybean and wheat are recognized as the principal sources of lunasin (14).…”

Section: Characterization Of Lunasinmentioning

confidence: 99%

See 1 more Smart Citation

Lunasin: A promising polypeptide for the prevention and treatment of cancer

et al. 2017

View full text Add to dashboard Cite

Abstract. Strategies for the treatment of cancer remain unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of types of cancer exhibit a marked association with dietary habits and lifestyles. Therefore, the modulation of dietary habits or lifestyles may be an effective strategy for preventing the formation and progression of cancer. Proteins and polypeptides from soybean have been developed as healthcare products due to their marked activity in inhibiting the progression of cancer at various stages. Lunasin, containing 43 amino acid residues, is one such example of a soybean-derived polypeptide that has been demonstrated to exhibit marked anti-cancer activity. In the present review, studies of the underlying molecular mechanisms and potential advantages of lunasin in the prevention and treatment of cancer have been examined, to provide a theoretical reference for the development of natural product-based agents or healthcare products for the prevention and treatment of cancer. IntroductionCancer is well-known to be one of the leading causes of mortality worldwide (1). However, the therapy of various types of cancer remains unsatisfactory due to the poor understanding of the complicated underlying molecular mechanisms of carcinogenesis. A number of epidemiological studies have demonstrated that a number of types of cancer exhibit a marked association with dietary habits and lifestyles (2-4). A statistical study has demonstrated that ~3.07 million individuals in China were diagnosed with cancer in 2012, which accounts for 1/5 of the total number of patients with cancer worldwide (5). Furthermore, ~2.21 million patients succumbed to cancer in China, which is ~25% of the total mortality worldwide due to cancer (5). Epidemiological evidence has demonstrated that cancer in 35% of patients exhibits a marked association with lifestyle, particularly diet (2). Therefore, the adjustment of dietary habits and lifestyles may be an effective strategy to prevent carcinogenesis. Cancer cell-and tumor-bearing animal models have demonstrated that the consumption of foods containing natural compounds with anti-cancer activity is able to markedly reduce the risk of cancer, and increase the sensitivity of cancer cells to treatment (6). A number of phytochemicals, including resveratrol, quercetin and flavonoids, have been demonstrated to exhibit marked anti-cancer activity (7-9). Similarly, foodborne proteins and polypeptides have attracted attention due to their specific advantages as anti-cancer substances (10,11). Compared with certain small-molecule drugs, polypeptides exhibit characteristics of increased affinity, marked ability of specific targeting and decreased toxicity; furthermore, polypeptides exhibit increased permeability in tissues compared with protein-based drugs (12). Therefore, polypeptides have been recognized as potential natural anti-cancer substances for inhibiting the development and progression of cancer at different stages (13).Following ...

show abstract

Section: Characterization Of Lunasinmentioning

confidence: 99%

Section: Characterization Of Lunasinmentioning

confidence: 99%

Lunasin: A promising polypeptide for the prevention and treatment of cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In search of natural sources of lunasin besides soybean, a first screening has been carried out using different beans, grains and herbal plants. Lunasin has been found in cereal grains known for its health effects, such as barley, wheat, and rye [24][25][26][27]. Several seeds of oriental herbal and medicinal plants have been analyzed, finding that lunasin is present in all of the Solanaceae family, except L. Chinensis, but not in any of the Phaseolus beans [28].…”

Section: Lunasin: Discovery and Beyondmentioning

confidence: 99%

“…First studies carried out in mice and rats fed lunasin-enriched soy protein found that 35% of ingested lunasin reaches the target tissues and organs in an intact and active form [17,28]. Lunasin from rye and barley have also shown stability towards pepsin and pancreatin in vitro digestion and the liver, kidney, and blood of rats fed with lunasin-enriched rye or barley, respectively, contained this peptide as detected by Western blot [26,27]. Naturally protease inhibitors, such as BowmanBirk protease inhibitor and Kunitz trypsin inhibitor have been demonstrated to exert a protective effect on lunasin against digestion by gastrointestinal enzymes, playing this protection a key role in making lunasin bioavailable [31].…”

Section: Bioavailability Of Lunasinmentioning

confidence: 99%

1997-2012: Fifteen Years of Research on Peptide Lunasin

Hernández-Ledesma¹,

Lumen²,

Hsieh³

2013

Bioactive Food Peptides in Health and Disease

Self Cite

View full text Add to dashboard Cite

“…Este péptido fue descubierto primero en la soya y posteriormente en la cebada, trigo y recientemente en el centeno coreano (Jeong et al, 2009). La lunasina es quimiopreventiva y se indica que tiene efectos en la reducción del co lesterol (Gálvez, 2008).…”

Section: Aminoácidos Y Péptidosunclassified

Compuestos importantes para la salud encontrados en los cereales enteros

Flores

2012

Ing. ind. (Lima)

View full text Add to dashboard Cite

Resumen: Los productos basados en granos enteros han ganado importan cia, pues se les considera entre los alimentos que mejoran la salud y redu cen el riesgo de enfermedades relacionadas con los hábitos alimentarios. La cáscara y el germen de los cereales contienen más vitaminas, minerales, antioxidantes naturales y fibra dietética que el endosperma, que principal mente contiene almidón y proteína. Estudios recientes indican que existen una serie de beneficios para la salud relacionados con el consumo de fibra dietética, entre los cuales se pueden mencionar la regulación de la glucosa de la sangre y del nivel de insulina, la reducción del colesterol de la sangre, la prevención del cáncer de colon y de desórdenes cardiovasculares. Palabras clave: Cereales / cáscara / salvado / salud / prevención de enfermedades Health important compounds found in whole grainsAbstRAct: Whole grain based products are gaining importance in improv ing health and reducing risk diseases related to food habits. Cereal bran and germ contain more vitamins, minerals, natural antioxidants and die tary fiber than the endosperm that mainly contains starch and protein. Actual research shows beneficial aspects for health related to the con sumption of dietary fiber like, for example, blood glucose and insulin level regulation improvement, blood cholesterol reduction and colonic cancer and cardiovascular disorders prevention. Keywords: Cereals / bran / health / preventionIngeniería Industrial n. o 30, 2012 208 Rafael Villanueva Flores INTRODUCCIÓNLos cereales constituyen la fuente principal de alimentos para el mun do. Cuando se consumen tras quitarle las cubiertas y el germen, se de nomina cereal 'refinado'. Cuando se procesa sin quitarle las cubiertas, el producto resultante se denomina 'entero'.En los últimos años, los productos basados en granos enteros han ganado atención debido a los beneficios que aportan a la salud. Pode mos definir a los granos enteros como aquellos granos intactos, moli dos, chancados o laminados luego de haberles removido las partes no comestibles, en los cuales sus principales componentes (endosperma, germen y cáscara) mantienen la misma proporción relativa, tal como existen en el grano intacto. Se consideran también aquellos que sufrie ron la separación temporal de sus componentes durante el procesa miento para una posterior recombinación.Cada día es más evidente que los productos elaborados sobre la base de granos enteros tienen potencial para mejorar la salud y para reducir el riesgo de enfermedades relacionadas con los hábitos alimentarios.Los cereales son principalmente fuente de carbohidratos provenien tes del endosperma del grano de donde se obtiene la mayoría de los pro ductos industriales, como la harina de trigo o el arroz pilado. Sin em bargo, también son una fuente importante de componentes favorables para la salud, como la fibra dietética, los prebióticos, los minerales, los lípidos, las vitaminas y las ligninas ubicados principalmente en la cás cara y el germen del grano que, en muchos casos, al ser ...

show abstract

The Cancer Preventive Seed Peptide Lunasin From Rye Is Bioavailable and Bioactive

Cited by 78 publications

References 18 publications

Lunasin: A promising polypeptide for the prevention and treatment of cancer

Lunasin: A promising polypeptide for the prevention and treatment of cancer

1997-2012: Fifteen Years of Research on Peptide Lunasin

Compuestos importantes para la salud encontrados en los cereales enteros

Contact Info

Product

Resources

About