volume 66, issue 9, P5667-5670 1992
DOI: 10.1128/jvi.66.9.5667-5670.1992
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Abstract: Deletion mutations at the C terminus of the matrix (MA) protein of human immunodeficiency virus type 1 (HIV1) were generated by site-directed mutagenesis. The resultant mutant viruses had a severe defect in virus infectivity. This defect did not involve late steps of the virus life cycle, as the synthesis and processing of the Gag polyprotein and the assembly and release of mutant virions were not greatly affected. The incorporation of viral proteins and the viral RNA genome was similar for mutant and wild-typ…

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