Journal of Cell Biology volume 217, issue 7, P2445-2462 2018 DOI: 10.1083/jcb.201709009 View full text
Tina L. Sing, Minnie P. Hung, Shinsuke Ohnuki, Godai Suzuki, Bryan-Joseph San Luis, Melainia McClain, Jay R. Unruh, Zulin Yu, Jiongwen Ou, Jesse Marshall-Sheppard, Won-Ki Huh, Michael Costanzo, Charles Boone, Yoshikazu Ohya et al.

Abstract: Ploidy is tightly regulated in eukaryotic cells and is critical for cell function and survival. Cells coordinate multiple pathways to ensure replicated DNA is segregated accurately to prevent abnormal changes in chromosome number. In this study, we characterize an unanticipated role for the "remodels the structure of chromatin" (RSC) complex in ploidy maintenance. We show that deletion of any of six nonessential RSC genes causes a rapid transition from haploid to diploid DNA content because of nondisjunction e…

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