The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer

John, Esther M.; Hopper, John L.; Beck, Jeanne C.; Knight, Julia A.; Neuhausen, Susan L.; Senie, Ruby T.; Ziogas, Argyrios; Andrulis, Irene L.; Anton‐Culver, Hoda; Boyd, Norman F.; Buys, Saundra S.; Daly, Mary B.; O’Malley, Frances P.; Santella, Regina M.; Southey, Melissa C.; Venne, Vickie L.; Venter, Deon J.; West, Dee W.; Whittemore, Alice S.; Seminara, Daniela

doi:10.1186/bcr801

Cited by 260 publications

(263 citation statements)

References 28 publications

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“…The Breast Cancer Family Registry is described in detail elsewhere. 21 Additional methodologic details from 2 of the study sites have also been published elsewhere. [22][23][24][25] The analysis was based on Caucasian women with a first primary invasive breast cancer who were compared to their sisters and Caucasian women from the general population without a personal history of breast cancer.…”

Section: Methodsmentioning

confidence: 99%

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

Knight

John

Milne

et al. 2005

Intl Journal of Cancer

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Ovarian cysts of several types are common in women of reproductive age. Their etiology is not well understood but is likely related to perturbations in the hypothalamic-pituitary-gonadal axis. The relationship of ovarian cysts to breast cancer risk is not known, although a negative association with polycystic ovarian syndrome has been reported. Incident, invasive female breast cancer cases, population-based controls and unaffected sisters of cases were studied from 3 countries participating in the Breast Cancer Family Registry: Melbourne and Sydney, Australia; the San Francisco Bay Area, USA; and Ontario, Canada. Using the same questionnaire, information was collected on self-reported history of ovarian cysts and other risk factors. Analyses were based on 3,049 cases, 2,344 population controls and 1,934 sister controls from all sites combined. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using both unconditional and conditional logistic regression using an offset term to account for sampling fractions at 2 of the sites. A significantly reduced risk of breast cancer was observed for women reporting a history of ovarian cysts (OR 5 0.70, 95% CI 0.59-0.82, among all cases and all controls). This risk estimate was similar regardless of control group used, within all 3 sites and in both premenopausal and postmenopausal women (ORs ranging from 0.68-0.75, all 95% CI excluded 1.00). A self-reported history of ovarian cysts was strongly and consistently associated with a reduced risk of breast cancer. Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology. ' 2005 Wiley-Liss, Inc.

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Section: Methodsmentioning

confidence: 99%

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

Knight

John

Milne

et al. 2005

Intl Journal of Cancer

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“…Eligible subjects were living non-Hispanic white women aged less than 50 years who carried a deleterious mutation in either BRCA1 or BRCA2 and were ascertained from the Breast Cancer Family Registry (Breast CFR), a consortium of research groups in the United States, Australia, and Canada [15], the Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), Australia and New Zealand (Australasia) [16], and the Ontario Cancer Genetics Network (OCGN), Canada. All sites collected pedigree and epidemiologic risk factor data and biospecimens.…”

Section: Participating Subjects and Sitesmentioning

confidence: 99%

Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years

Whittemore

John

Felberg

et al. 2007

Breast Cancer Res Treat

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Background-Cigarette smoke contains compounds that may damage DNA, and the repair of damage may be impaired in women with germline mutations in BRCA1 or BRCA2. However, the effect of cigarette smoking on breast cancer risk in mutation carriers is the subject of conflicting reports. We have examined the relation between smoking and breast cancer risk in non-Hispanic white women under the age of 50 years who carry a deleterious mutation in BRCA1 or BRCA2.Methods-We conducted a case-control study using data from carriers of mutations in BRCA1 (195 cases and 302 controls) and BRCA2 (128 cases and 179 controls). Personal information, including smoking history, was collected using a common structured questionnaire by eight recruitment sites in four countries. Odds-ratios (OR) for breast cancer risk according to smoking were adjusted for age, family history, parity, alcohol use, and recruitment site. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptResults-Compared to non-smokers, the OR for risk of breast cancer for women with five or more pack-years of smoking was 2.3 (95% confidence interval 1.6-3.5) for BRCA1 carriers and 2.6 (1.8-3.9) for BRCA2 carriers. Risk increased 7% per pack-year (p < 0.001) in both groups. The epidemiological evidence on the association of smoking with risk of breast cancer is contradictory. Terry and Rohan in 2002 reviewed the published evidence and concluded that smoking probably did not decrease, and may increase, risk of breast cancer [6]. A combined re-analysis of 53 epidemiological studies, however, did not show smoking to be associated with an increased risk of breast cancer after alcohol use was taken into account [7]. In a meta-analysis in 2005, Johnson found that both active and passive smoking were associated with an increased risk of premenopausal breast cancer [8]. Conclusions-TheseThe biological effects of smoking suggest that genetic variations in acetylation, oxidative damage, and DNA repair, may influence risk of disease. For example, high levels of reactive oxygen species may cause single and double strand breaks. BRCA1 and BRCA2 genes are involved in the repair of such breaks [9], and mutations in these genes may impair the ability of carriers to repair any defects caused by smoking.Lifetime risks of breast cancer among carriers of deleterious mutations in BRCA1 and BRCA2 have been estimated at 40-80% [10][11][12]. Because 20-60% of carriers live to an advanced age, and do not develop breast cancer, there are likely to be other genetic or environmental factors that modify risk. The purpose of the present study was to examine the effects of cigarette smoking on breast cancer risk in a large number of affected (cases) and unaffected (controls) members of families segregating mutations in the BRCA1 or BRCA2 genes.et al.

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“…The study population was selected from families participating in the New York site of the Breast Cancer Family Registry (BCFR). 24 The New York site of the BCFR recruited high risk breast and/or ovarian cancer families from cancer clinics within the Metropolitan New York area. Families were eligible to participate if the family had at least one of the following: (1) a female relative with breast or ovarian cancer diagnosed before age 45 years, (2) a female relative with both breast and ovarian cancer regardless of age at diagnosis, (3) two or more relatives with breast or ovarian cancer diagnosed after age 45 years, (4) a male with breast cancer diagnosed at any age or (5) a family member with a known BRCA mutation.…”

Section: Methodsmentioning

confidence: 99%

Global methylation profiles in DNA from different blood cell types

et al. 2011

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The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer

Cited by 260 publications

References 28 publications

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

An inverse association between ovarian cysts and breast cancer in the breast cancer family registry

Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years

Global methylation profiles in DNA from different blood cell types

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