The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease

Oak, Prajakta; Hilgendorff, Anne

doi:10.1186/s40348-017-0076-8

Cited by 32 publications

(27 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in line with our previous observations from the plasma proteome, functional analysis also suggested involvement of blood cells, blood platelets, and the fibronectin matrix (31), as well as proteins related to endothelial cell, epithelial cell, fibroblast, and neuronal function. Furthermore, our proteomic analysis not only confirmed known neonatal lung injury pathways, such as the extensively studied vascular endothelial growth factor (32,33) and IL-6 (34-36) signaling pathways, but also identified an entirely novel association with three closely related RXR-mediated nuclear receptor families: LXR/RXR, FXR/RXR, and PPARa/RXRa. Each of the nuclear receptors forms a heterodimer with RXR, and can be activated with agonists against either LXR/FXR/PPARa or RXR during oxidative stress (37,38) or under conditions of energy deprivation (39), resulting in activation of target genes involved in lipogenesis and inflammation.…”

Section: Discussionsupporting

confidence: 63%

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury

Pereira‐Fantini¹,

Pang²,

Byars

et al. 2019

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

The development of regional lung injury in the preterm lung is not well understood. This study aimed to characterize time-dependent and regionally specific injury patterns associated with early ventilation of the preterm lung using a mass spectrometry-based proteomic approach. Preterm lambs delivered at 124-127 days gestation received 15 or 90 minutes of mechanical ventilation (positive end-expiratory pressure = 8 cm H 2 O, VT = 6-8 ml/kg) and were compared with unventilated control lambs. At study completion, lung tissue was taken from standardized nondependent and dependent regions, and assessed for lung injury via histology, quantitative PCR, and proteomic analysis using Orbitrap-mass spectrometry. Ingenuity pathway analysis software was used to identify temporal and region-specific enrichments in pathways and functions. Apoptotic cell numbers were ninefold higher in nondependent lung at 15 and 90 minutes compared with controls, whereas proliferative cells were increased fourfold in the dependent lung at 90 minutes. The relative gene expression of lung injury markers was increased at 90 minutes in nondependent lung and unchanged in gravity-dependent lung. Within the proteome, the number of differentially expressed proteins was fourfold higher in the nondependent lung than the dependent lung. The number of differential proteins increased over time in both lung regions. A total of 95% of enriched canonical pathways and 94% of enriched cellular and molecular functions were identified only in nondependent lung tissue from the 90-minute ventilation group. In conclusion, complex injury pathways are initiated within the preterm lung after 15 minutes of ventilation and amplified by continuing ventilation. Injury development is region specific, with greater alterations within the proteome of nondependent lung.

show abstract

Section: Discussionsupporting

confidence: 63%

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury

Pereira‐Fantini¹,

Pang²,

Byars

et al. 2019

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

show abstract

“…Periostin and TGF-β are known to play a critical role in the proliferation of lung broblasts (9). Furthermore, many studies in different animal models of BPD con rm elevated TGF-β expression levels and activation of its associated pathways as an important part of lung disease pathophysiology (22,26,27). Also, we previously reported that serum TGF-β levels were upregulated in BPD patients (28).…”

Section: Discussionmentioning

confidence: 88%

Serum Periostin Levels at Birth as a Predictor for Bronchopulmonary Dysplasia in Premature Infants.

Ono²,

Ohto

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Bronchopulmonary dysplasia (BPD) is the most common morbidity complicating preterm birth and affects long-term respiratory outcomes. Periostin plays an important role in the development of various disease such as allergic and pulmonary diseases. The objectives of this study were to evaluate the perinatal factors affecting serum periostin levels at birth and to establish whether serum periostin at birth, day of life (DOL) 28 and corrected 36 week’s gestational age could be potential biomarkers for BPD.Methods: A total of 139 preterm (n=98) and healthy (n=41) infants were included in this study. Among of them, 98 infants born < 32 weeks were divided into BPD (n=44) and non-BPD infants (n=54). Serum periostin levels were measured using an enzyme-linked immunosorbent assay. Results: The median serum periostin levels at birth in preterm infants born < 32 weeks were significantly higher than those in healthy infants. Furthermore, there were significant inverse correlations between gestational age, birth weight, and serum periostin levels at birth among all 139 preterm and healthy infants. Among preterm infants born < 32 weeks, with BPD and without BPD infants, the median serum periostin levels at birth were higher with BPD than without (345.0 ng/mL vs 278.0 ng/mL, P=0.002). Multivariate analysis revealed that serum periostin levels at birth was significantly associated with BPD (P=0.032). Receiver operating characteristic analysis for serum periostin levels at birth in infants with and without BPD revealed that the area under the curve were 0.725 (95% CI 0.627- 0.822, P=0.0001). Serum periostin levels at birth with moderate/severe BPD were significantly higher than those with non-BPD/mild BPD (338.5 ng/mL vs 283.5 ng/mL, P=0.0032).Conclusions: Serum periostin levels at birth were significantly correlated with BW and GA. Furthermore, serum periostin levels at birth could serve as a biomarker for predicting BPD.

show abstract

“…In recent studies, it has been demonstrated that platelet-derived growth factor (PDGF), serving as a vital regulator of alveolar septation, VEGF serving as a vital regulator of pulmonary vascular development, and transforming growth factor (TGF), which affects the apoptosis, matrix remodeling, inflammatory process of pulmonary development play an important part in the pathogenesis of BPD. 29 Studies have consistently demonstrated that plateletrich plasma is also rich in the above-mentioned growth factors, such as PDGF, TGF, and VEGF, and have large effect on the formation of BPD. 30 Moreover, platelets also have important roles in the proinflammatory process.…”

Section: Discussionmentioning

confidence: 99%

Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?

et al. 2018

View full text Add to dashboard Cite

Objective Intraventricular hemorrhage (IVH) is an important problem in neonatal units not only in terms of its consequences but also its follow-up and the prediction of its emergence in newborns. In this study, we have compared platelet parameters such as platelet count (PC), mean platelet volume (MPV), and platelet mass index (PMI) in terms of IHV in very-low-birth-weight (VLBW) newborns. Thus, we have tried to determine platelet values to guide clinicians in both the prediction and follow-up of IVH. Study Design This is a retrospective, multicenter, and case-controlled study. In this study, 386 cases of VLBW newborns (below 1,500 g) and gestational age below 32 weeks, hospitalized and monitored between August 8, 2012, and April 7, 2018, were included. The platelet values of the cases on their 12th hour postpartum (PC1, MPV1, and PMI1) and the platelet values on days 5 to 7 (PC2, MPV2, and PMI2) were recorded in their study cards. A p-value of <0.05 was accepted as statistically significant. Results While there was no difference of PC1, MPV1, PMI1, PC2, or MPV2 values (p > 0.05), PMI2 values in the severe stage IVH group cases were found to be significantly lower compared with other platelet parameters (p < 0.05). Conclusion PMI2 values can provide clinicians with important knowledge that may aid them in recognizing important pathologies such as IVH.

show abstract

The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease

Cited by 32 publications

References 98 publications

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury

Serum Periostin Levels at Birth as a Predictor for Bronchopulmonary Dysplasia in Premature Infants.

Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?

Contact Info

Product

Resources

About