The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

Kim, Joo Heon; Yoon, Sun Young; Kim, Chang-Nam; Joo, Joung Hyuck; Moon, Sang Kyoung; Choe, In Seong; Choe, Yong-Kyung; Kim, Jae Wha

doi:10.1016/j.canlet.2003.07.009

Cited by 220 publications

(159 citation statements)

References 22 publications

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“…It is known, the encoded protein of Bmi-1 , as well as other proteins from the PcG family, can block the transcription of some genes such as p16Ink4a and p19Arf involved in tumour suppression, resulting in oncogenic effects [14]. In our previous investigation, however, we found that Bmi-1 may promote immortalization of nasopharyngeal carcinoma by modulating the expression of other genes, besides regulating p16Ink4a.…”

Section: Discussionmentioning

confidence: 83%

“…By utilizing the criterion of a semi-quantitative scale as previously described [14], we found that 36% (64/179) and 17% (30/179) of ovarian carcinomas had negative/down-regulated expression of p16Ink4a and p14ARF, respectively. Further correlation analysis demonstrated that no significant correlation between Bmi-1 expression and expression of either p16Ink4a or p14ARF was evaluated in these ovarian carcinoma cohorts ( P > 0.05, Fishers exact test).…”

Section: Resultsmentioning

confidence: 93%

“…Datas from several clinical studies show that abnormal expression of Bmi-1 , in protein level as well as in gene level, is favorably associated with poor prognostic markers and clinical outcome in diverse human cancers, such as colorectal cancer, nasopharyngeal carcinoma, bladder cancer and myelodysplastic syndrome [14,17-19]. However, to our best knowledge, there is little information about prognostic status and clinical outcome of Bmi-1 expression in ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

“…1D and 1E). The evaluation of p16Ink4a and p14ARF IHC staining was scored on a semi-quantitative scale [14], as follows: negative expression (<10% of the cells were positive), down-regulated expression (small cell clusters, but 10-50% of the cells were positive) and diffuse expression (>50% of the cells were positive). Results were observed and assessed by two independent pathologic doctors, without knowing the identity of the samples.…”

Section: Methodsmentioning

confidence: 99%

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Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

Yang

Cai

et al. 2010

BMC Cancer

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BackgroundIt has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression in ovarian cancer and its clinical/prognostic significance are unclear.MethodsThe methods of immunohistochemistry and fluorescence in situ hybridization were utilized to examine protein expression and amplification of Bmi-1 in 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors and 179 ovarian carcinomas.ResultsIntensive expression of Bmi-1 was detected in none of the normal ovaries, 3% cystadenomas, 10% borderline tumors, and 37% ovarian carcinomas, respectively. Amplification of Bmi-1 was detected in 8% of ovarian carcinomas. In ovarian carcinomas, significant positive associations were found between intensive expression of Bmi-1 and the tumors ascending histological grade, later pT/pN/pM and FIGO stages (P < 0.05). In univariate survival analysis of the ovarian carcinoma cohorts, a significant association of intensive expression of Bmi-1 with shortened patient survival (mean 49.3 months versus 100.3 months, p < 0.001) was demonstrated. Importantly, Bmi-1 expression provided significant independent prognostic parameters in multivariate analysis (p = 0.005).ConclusionsThese findings provide evidence that intensive expression of Bmi-1 might be important in the acquisition of an invasive and/or aggressive phenotype of ovarian carcinoma, and serve as a independent biomarker for shortened survival time of patients.

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Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

Yang

Cai

et al. 2010

BMC Cancer

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“…Bmi-1 plays an essential role in maintaining the self-renewal of normal and malignant human mammary stem cells [122]. Over-expression of Bmi-1 is reported and correlated to poor clinical prognosis in solid tumors of breast [123], lung [124] and colon [125] cancers; to name but a few. Silva et al [98] investigated Bmi-1 mRNA expression in plasma of a cohort of patients presenting with various subtypes and stages of breast cancer.…”

Section: Bmi-1mentioning

confidence: 99%

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Friel

Corcoran

Crown

et al. 2010

Breast Cancer Res Treat

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Early detection of cancer is vital to improved overall survival rates. At present, evidence is accumulating for the clinical value of detecting occult tumor cells in peripheral blood, plasma, and serum specimens from cancer patients. Both molecular and cellular approaches, which differ in sensitivity and specificity, have been used for such means. Circulating tumor cells and extracellular nucleic acids have been detected within blood, plasma, and sera of cancer patients. As the presence of malignant tumors are clinically determined and/or confirmed upon biopsy procurement-which in itself may have detrimental effects in terms of stimulating cancer progression/metastases-minimally invasive methods would be highly advantageous to the diagnosis and prognosis of breast cancer and the subsequent tailoring of targeted treatments for individuals, if reliable panels of biomarkers suitable for such an approach exist. Herein, we review the current advances made in the detection of such circulating tumor cells and nucleic acids, with particular emphasis on extracellular nucleic acids, specifically extracellular mRNAs and discuss their clinical relevance.

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Assessment of clinicopathological and prognostic relevance of BMI‐1 in patients with colorectal cancer: A meta‐analysis

Pourjafar

Samadi

Karami

et al. 2020

Biotechnology and Applied Biochemistry

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B‐cell‐specific Moloney leukemia virus insertion site 1 (BMI‐1) is one of the stemness markers. The prognostic and clinicopathological effects of BMI‐1 expression in colorectal cancer (CRC) have been in dispute with different studies. Eligible studies were retrieved from international databases up to December 2019. Studies with a relationship between the clinicopathological and prognostic value of CRC patients with BMI‐1 expression were selected. The correlations in the random‐effect model were evaluated using the hazard ratios, odds ratio, and 95% confidence intervals (CIs). A total of nine studies comprising Asian cases (seven studies) and European cases (two studies) covering 1,294 samples of CRC were included for this meta‐analysis. The analysis suggested that in Asian cases, increased expression of BMI‐1 was associated with poor overall survival (OS) and death‐free survival, whereas in European populations, high expression of BMI‐1 was associated with better OS. Also, overexpression of BMI‐1 in the Asian population was associated with the tumor size, distant metastasis, and patient's gender and age. Results suggested that high expression of BMI‐1 can be involved in the progression and invasion of CRC, and so its inhibitor‐based therapies could be used to prevent the progression of CRC.

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The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

Cited by 220 publications

References 22 publications

Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Assessment of clinicopathological and prognostic relevance of BMI‐1 in patients with colorectal cancer: A meta‐analysis

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