The BladderPill: An in-body system logging bladder pressure

Jourand, Philippe; Puers, Robert

doi:10.1016/j.sna.2010.01.035

Cited by 21 publications

(21 citation statements)

References 14 publications

(19 reference statements)

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“…Clasbrummel [7] suggested suturing the system inside the bladder, other systems are too large so that an expulsion is impossible [6], but they are not implantable through a cystoscope. Some authors give no information how to prevent an expulsion [8]. We suggest a Cshaped flexible capsule that in straightened state can be pushed or pulled through a cystoscope and inside the bladder becomes C-shaped, therefore an expulsion is not possible.…”

Section: Catheterless Pressure Measurementmentioning

confidence: 92%

“…The catheterless pressure measurement is generally of great interest for many medical applications such as intracranial pressure measurement [3] or real-time blood pressure measurement [4]. Some devices have been designed especially for the intravesical pressure measurement [5][6][7][8]. Implantable measurement systems have to be very small, so that the power supply is one of the most crucial topics.…”

Section: Catheterless Pressure Measurementmentioning

confidence: 99%

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A new catheterless urodynamics measurement method by using an intravesical capsule

Hamacher¹,

Tenholte²,

Schumacher³

et al. 2012

Biomedical Engineering / Biomedizinische Technik

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Urodynamics is considered as a standard diagnostic test for urinary incontinence using catheter tip sensors to measure the bladder pressure. Standard urodynamic measurement takes about 30 minutes, thus it is often not possible to monitor pathological change of pressure during this short period of time. In addition, different psychosocial factors could affect the result of standard urodynamics. In this paper we describe a new system for catheterless urodynamic measurement. The system consists of an implantable intravesical capsule that measures the pressure over a period of up to 72 hours. The system needs no components outside of the human body, so an outpatient treatment is possible, which allows measurements under conditions of the patient's daily routine.

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Section: Catheterless Pressure Measurementmentioning

confidence: 92%

Section: Catheterless Pressure Measurementmentioning

confidence: 99%

A new catheterless urodynamics measurement method by using an intravesical capsule

Hamacher¹,

Tenholte²,

Schumacher³

et al. 2012

Biomedical Engineering / Biomedizinische Technik

View full text Add to dashboard Cite

show abstract

“…However, the conformality of the coating must be carefully monitored, as silicone rubber may have poor coverage and reveal cytotoxic regions at sharp edges of the device [ 115 ]. The addition of a silicone or Parylene coating over the membrane structure was found to reduce sensitivity [ 39 , 57 , 93 , 112 , 116 ], and thus degrading the signal-to-noise ratio and compromising the measurement resolution. Furthermore, PDMS encapsulation was found to negatively impact frequency response, causing a 1–2 s delay in the pressure measurement due to increased viscoelastic nature of the membrane [ 117 ].…”

Section: Sensing Technologies and State Of The Fieldmentioning

confidence: 99%

Chronically Implanted Pressure Sensors: Challenges and State of the Field

Liu

Kim

Meng

2014

Sensors

159

107

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Several conditions and diseases are linked to the elevation or depression of internal pressures from a healthy, normal range, motivating the need for chronic implantable pressure sensors. A simple implantable pressure transduction system consists of a pressure-sensing element with a method to transmit the data to an external unit. The biological environment presents a host of engineering issues that must be considered for long term monitoring. Therefore, the design of such systems must carefully consider interactions between the implanted system and the body, including biocompatibility, surgical placement, and patient comfort. Here we review research developments on implantable sensors for chronic pressure monitoring within the body, focusing on general design requirements for implantable pressure sensors as well as specifications for different medical applications. We also discuss recent efforts to address biocompatibility, efficient telemetry, and drift management, and explore emerging trends.

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“…Another way to enhance a hermetic and biocompatible package is to have a second encapsulation, commonly with silicone rubber or a parylene coating [ 38 - 41 ]. Silicone and parylene coatings were found to improve biocompatibility and reduce offset drift of implantable bladder sensors; however, it was discovered that they could also reduce the sensitivity of the implantable bladder sensor [ 41 - 45 ]. Furthermore, PDMS encapsulation was found to have a negative impact on frequency response by degrading it [ 46 ].…”

Section: Improvements/emerging Trends In Implantable Bladder Sensor Dmentioning

confidence: 99%

Implantable Bladder Sensors: A Methodological Review

et al. 2015

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The loss of urinary bladder control/sensation, also known as urinary incontinence (UI), is a common clinical problem in autistic children, diabetics, and the elderly. UI not only causes discomfort for patients but may also lead to kidney failure, infections, and even death. The increase of bladder urine volume/pressure above normal ranges without sensation of UI patients necessitates the need for bladder sensors. Currently, a catheter-based sensor is introduced directly through the urethra into the bladder to measure pressure variations. Unfortunately, this method is inaccurate because measurement is affected by disturbances in catheter lines as well as delays in response time owing to the inertia of urine inside the bladder. Moreover, this technique can cause infection during prolonged use; hence, it is only suitable for short-term measurement. Development of discrete wireless implantable sensors to measure bladder volume/pressure would allow for long-term monitoring within the bladder, while maintaining the patient’s quality of life. With the recent advances in microfabrication, the size of implantable bladder sensors has been significantly reduced. However, microfabricated sensors face hostility from the bladder environment and require surgical intervention for implantation inside the bladder. Here, we explore the various types of implantable bladder sensors and current efforts to solve issues like hermeticity, biocompatibility, drift, telemetry, power, and compatibility issues with popular imaging tools such as computed tomography and magnetic resonance imaging. We also discuss some possible improvements/emerging trends in the design of an implantable bladder sensor.

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The BladderPill: An in-body system logging bladder pressure

Cited by 21 publications

References 14 publications

A new catheterless urodynamics measurement method by using an intravesical capsule

A new catheterless urodynamics measurement method by using an intravesical capsule

Chronically Implanted Pressure Sensors: Challenges and State of the Field

Implantable Bladder Sensors: A Methodological Review

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