Pediatr. Pulmonol.
 1996
DOI: 10.1002/(sici)1099-0496(199611)22:5<287::aid-ppul1>3.3.co;2-k
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The biphasic ventilatory response to hypoxia in preterm infants is not due to a decrease in metabolism

Virender K. Rehan
1
,
A. Zia Haider
2
,
Ruben Alvaro
3
et al.
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Cited by 12 publications

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“…In contrast, the hypoxic depression is primarily mediated by reductions in VT (3, 5-7, 23, 25, 41, 47). However, as seen here for Swiss CD-1 mice of all ages except P 0 , and for human infants (24,39), reductions in f can also contribute (3,14).…”
Section: Discussionsupporting
confidence: 61%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In contrast, the hypoxic depression is primarily mediated by reductions in VT (3, 5-7, 23, 25, 41, 47). However, as seen here for Swiss CD-1 mice of all ages except P 0 , and for human infants (24,39), reductions in f can also contribute (3,14).…”
Section: Discussionsupporting
confidence: 61%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This hypothesis is supported by the fact that preterm infants with apnoea also exhibit prolonged auditory evoked responses (15), an indirect marker of brainstem immaturity. Moreover, our extremely preterm infants exhibited developmental changes in apnoea/hypopnoea characteristics that mirror maturation of hypoxic responsiveness; specifically, hypoxic ventilatory depression is manifested by a greater reduction in RR than V t during early postnatal life (16) followed by an improved ability to sustain RR during hypoxia with advancing age. During this critical period of respiratory plasticity (17), there is an increased vulnerability to inhibitory stimuli such as prostaglandin (18,19) and postnatal insults such as infection that likely predisposes these extremely preterm infants to apnoea.…”
Section: Discussionmentioning
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Infants typically exhibit a biphasic response to hypoxia, in which transient hyperventilation is followed by a sustained reduction in the ventilation rate (at or below normoxic levels). This biphasic response has been demonstrated in newborn animals from various species, in term human infants and preterm human infants during both wakefulness and sleep. We have previously applied an analytical method that avoids underestimation .…”
Section: Introductionmentioning
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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