The Biology and Molecular Basis of Organ Transplant Rejection

Halloran, Philip F.; Einecke, G.; Sikosana, Majid L N; Madill‐Thomsen, Katelynn S.

doi:10.1007/164_2021_557

Cited by 8 publications

(9 citation statements)

References 109 publications

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“…16 Transplant rejection occurs as a result of the body's own immune system creating antibodies against the alloantigen from the transplanted kidney. 17 The response can be variable in intensity and onset, it ranges from hyperacute which can happen within minutes of transplant and is usually related to preformed antibodies or ABO mismatch. Acute rejection occurs any time following transplant and is subclassified depending on the underlying factor and immune mechanism to antibody-mediated rejection (ABMR), which usually happens as a result of donor-specific alloantibodies damaging the kidney causing peritubulitis/capillaritis.…”

Section: F I G U R Ementioning

confidence: 99%

A rare case of non‐lupus full house nephropathy in a transplanted kidney, case report

Matarneh,

Salameh,

Sardar

et al. 2024

Clinical Case Reports

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Key Clinical MessageNon‐lupus full house nephropathy is a rare entity that is still poorly understood. It can complicate post‐transplant kidneys and result in a de novo process. Treatment is difficult but can be possibly achieved with optimization of immune suppression.AbstractNon‐lupus full house nephropathy is a rare entity with an unclear incidence. It describes the kidney biopsy findings of positive deposits for IgG, IgA, IgM, C3, and C1q on immunofluorescence in the absence of the classical diagnostic features of systemic lupus nephritis. This disease entity is becoming more recognized but further studies are still needed to evaluate the incidence, etiologies, and management of this condition. Transplant glomerulopathy is a major cause for renal graft loss. It can present with a wide variety of manifestations; it can cause AKI, CKD, or glomerular inflammations through an immune complex or autoimmune‐mediated damage.

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Section: F I G U R Ementioning

confidence: 99%

A rare case of non‐lupus full house nephropathy in a transplanted kidney, case report

Matarneh,

Salameh,

Sardar

et al. 2024

Clinical Case Reports

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“…Other studies have tried investigating endothelialization by implanting ECs from both arterial and venous routes. As an example, to recellularize acellular rat heart vasculature, rat aortic endothelial cells have been infused in three directions: ( Graham et al, 2022 ): retrograde aortic infusion, ( Organ donation, 2023 ), antegrade brachiocephalic artery (BA) infusion, and ( Halloran et al, 2022 ) retrograde inferior vena cava (IVC) and antegrade BA combined infusion ( Robertson et al, 2014 ). It was observed that re-endothelialization improved with cell delivery through combined IVC + BA routes than single-route retrograde aortic or antegrade BA infusion.…”

Section: The Role Of Bioreactors In Favorable Endothelializationmentioning

confidence: 99%

“…Organ donation contraindications, long waiting lists, and mismatched donor and recipient statistics are challenging organ transplantation issues. Besides, a lack of existing therapies and limitations associated with transplantation procedures (e.g., post-surgery isolation and long-term immunosuppression therapy) may predispose patients to severe infections, malignancies, and transplant rejection ( Halloran et al, 2022 ). Thus, these challenges call for researchers to suggest alternatives to conventional transplanting methods.…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis and Re-endothelialization in decellularized scaffolds: Recent advances and current challenges in tissue engineering

Mazloomnejad

Babajani

Kasravi

et al. 2023

Front. Bioeng. Biotechnol.

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Decellularization of tissues and organs has recently become a promising approach in tissue engineering and regenerative medicine to circumvent the challenges of organ donation and complications of transplantations. However, one main obstacle to reaching this goal is acellular vasculature angiogenesis and endothelialization. Achieving an intact and functional vascular structure as a vital pathway for supplying oxygen and nutrients remains the decisive challenge in the decellularization/re-endothelialization procedure. In order to better understand and overcome this issue, complete and appropriate knowledge of endothelialization and its determining variables is required. Decellularization methods and their effectiveness, biological and mechanical characteristics of acellular scaffolds, artificial and biological bioreactors, and their possible applications, extracellular matrix surface modification, and different types of utilized cells are factors affecting endothelialization consequences. This review focuses on the characteristics of endothelialization and how to optimize them, as well as discussing recent developments in the process of re-endothelialization.

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“…Glomerulitis (Banff g) and capillaritis (Banff ptc), or microvascular inflammation (Banff mi), remain as key features. Over the past decade, microarray studies using prospectively collected kidney allograft biopsy samples have established gene sets that define TCMR and AMR [1].…”

Section: Pathologic Features and Outcomesmentioning

confidence: 99%

“…Bulk mRNA analysis of renal transplant biopsies by Halloran's et al [1] using Affymetrix microarrays has led to many insights into pathogenesis of rejection and revealed opportunities to improve diagnosis. The major limitation of this technique is the need for separate sample processing done at the time of biopsy.…”

Section: Transcript Analysis Of Biopsiesmentioning

confidence: 99%

Histologic and molecular features of antibody-mediated rejection

Rosales

Smith

Colvin

2023

Current Opinion in Organ Transplantation

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Purpose of review This review aims to summarize the highlights from recent research that involved pathological and molecular analysis of kidney allografts. Recent findings As the research on antibody-mediated rejection (AMR) continues to evolve, studies are focused on identification through transcript studies of pathogenetic pathways involved in the development of AMR as well as refinement of diagnostic methods either by correlating Banff pathologic lesions with clinical and molecular data or by machine learning. Of note, the past year has generated high impact research that underscore the importance of pathologic and molecular correlations and detection of transcripts or gene sets that would aid prognostication. The studies involving refinement of pathologic criteria also highlight the continuous efforts to achieve diagnostic accuracy and standardization. Summary Research involving histologic and molecular characteristics that define AMR are central to identification and understanding of pathogenetic pathways and remain critical in the development of diagnostic criteria.

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The Biology and Molecular Basis of Organ Transplant Rejection

Cited by 8 publications

References 109 publications

A rare case of non‐lupus full house nephropathy in a transplanted kidney, case report

A rare case of non‐lupus full house nephropathy in a transplanted kidney, case report

Angiogenesis and Re-endothelialization in decellularized scaffolds: Recent advances and current challenges in tissue engineering

Histologic and molecular features of antibody-mediated rejection

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