The Biological Promise of Microbial Endophytes and Their Natural Products

Strobel, Gary A.; Daisy, Bryn; Castillo, Uvidello

doi:10.3923/ppj.2005.161.176

Cited by 28 publications

(12 citation statements)

References 53 publications

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“…A recent review revealed plant products to be a quarter of FDA-approved new molecular entities (NMEs) (Patridge et al 2016). It is also noteworthy that each plant hosts numerous endophytes, the microorganisms that reside in plants (Strobel and Daisy 2003).…”

Section: Endophytic Actinomycetes As a Source Of New Bioactive Moleculesmentioning

confidence: 99%

Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies

Ossai

Khatabi

Nybo

et al. 2021

J of Applied Microbiology

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Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including bacterial isolation, fermentation, metabolite identification, and structure elucidation have resulted in high rates of natural product rediscovery in recent years. Recent advancements in multi-omics techniques have uncovered cryptic gene clusters within the genomes of actinomycetes, potentially introducing vast resources for the investigation of bioactive molecules. While developments in culture techniques have allowed for the fermentation of difficult-to-culture actinomycetes, high throughput metabolite screening has offered plenary tools to accelerate hits discovery. A variety of new bioactive molecules have been isolated from actinomycetes of unique environmental origins, such as endophytic and symbiotic actinomycetes. Synthetic biology and genome mining have also emerged as new frontiers for the discovery of bioactive molecules. This review covers the highlights of recent developments in actinomycete-derived natural product drug discovery.

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Section: Endophytic Actinomycetes As a Source Of New Bioactive Moleculesmentioning

confidence: 99%

Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies

Ossai

Khatabi

Nybo

et al. 2021

J of Applied Microbiology

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“…However, some species such as G. citricarpa and G. psidii cause serious diseases to agriculture by infesting fruit and leaves post-harvest. General studies of endophytes are more prevalent in temperate regions [26] and should be extended to tropical species when considering the pharmaceutical potential of tropical medicinal plants [27].…”

Section: Resultsmentioning

confidence: 99%

Endophytic Mycobiota Characterization of the Amazonian Mistletoe <i>Cladocolea micrantha</i> Hosted in Cashew Tree

Guimarães¹,

Siani

Bezerra³

et al. 2013

AJPS

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Endophytic fungi were identified from different parts of the medicinal parasitic mistletoe Cladocolea micrantha and from its host Anacardium occidentale, suggesting a strict host-parasite relationship. Eight fungal endophytes were isolated and morphologically characterized. The ascomycete Guignardia mangiferae and strains of Mycelia sterilia were prevalent in the isolations. The unequivocal identification of Guignardia mangiferae at a probabilistic degree close to 100% was carried out by DNA extraction followed by PCR analyses of the ITS-1 and ITS-2 regions and comparison of the genetic sequence with the NCBI database.

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“…Endophytes acquired a specific ability that allows them to sustain under the living tissues without any detectable infectious symptoms to the host. Thus, they are of immense importance to the host due to their capability to produce a wide array of natural bioactive compounds (Sardi et al, 1992;Strobel and Daisy, 2003;Cao et al, 2005;Kim et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Distribution and Identification of Endophytic Streptomyces Species from Schima wallichii as Potential Biocontrol Agents against Fungal Plant Pathogens

Passari

Mishra

Gupta

et al. 2016

Polish Journal of Microbiology

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A b s t r a c tThe prospective of endophytic microorganisms allied with medicinal plants is disproportionally large compared to those in other biomes. The use of antagonistic microorganisms to control devastating fungal pathogens is an attractive and eco-friendly substitute for chemical pesticides. Many species of actinomycetes, especially the genus Streptomyces, are well known as biocontrol agents. We investigated the culturable community composition and biological control ability of endophytic Streptomyces sp. associated with an ethanobotanical plant Schima wallichi. A total of 22 actinobacterial strains were isolated from different organs of selected medicinal plants and screened for their biocontrol ability against seven fungal phytopathogens. Seven isolates showed significant inhibition activity against most of the selected pathogens. Their identification based on 16S rRNA gene sequence analysis, strongly indicated that all strains belonged to the genus Strepto myces. An endophytic strain BPSAC70 isolated from root tissues showed highest percentage of inhibition (98.3 %) against Fusarium culmorum with significant activity against other tested fungal pathogens. Phylogenetic analysis based on 16S rRNA gene sequences revealed that all seven strains shared 100 % similarity with the genus Streptomyces. In addition, the isolates were subjected to the amplification of antimicrobial genes encoding polyketide synthase type I (PKS-I) and nonribosomal peptide synthetase (NRPS) and found to be present in most of the potent strains. Our results identified some potential endophytic Streptomyces species having antagonistic activity against multiple fungal phytopathogens that could be used as an effective biocontrol agent against pathogenic fungi. K e y w o r d s: Schima wallichii, biocontrol agent, endophytic Streptomyces, nonribosomal peptide synthetase (NRPS), polyketide synthase (PKS-I)

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The Biological Promise of Microbial Endophytes and Their Natural Products

Cited by 28 publications

References 53 publications

Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies

Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies

Endophytic Mycobiota Characterization of the Amazonian Mistletoe <i>Cladocolea micrantha</i> Hosted in Cashew Tree

Distribution and Identification of Endophytic Streptomyces Species from Schima wallichii as Potential Biocontrol Agents against Fungal Plant Pathogens

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The Biological Promise of Microbial Endophytes and Their Natural Products

Cited by 28 publications

References 53 publications

Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies

Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies

Endophytic Mycobiota Characterization of the Amazonian Mistletoe &lt;i&gt;Cladocolea micrantha&lt;/i&gt; Hosted in Cashew Tree

Distribution and Identification of Endophytic Streptomyces Species from Schima wallichii as Potential Biocontrol Agents against Fungal Plant Pathogens

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Endophytic Mycobiota Characterization of the Amazonian Mistletoe <i>Cladocolea micrantha</i> Hosted in Cashew Tree