Biochemical Pharmacology volume 78, issue 8, P933-940 2009 DOI: 10.1016/j.bcp.2009.05.018 View full text
Zaid Abassi, Joseph Winaver, Giora Z. Feuerstein

Abstract: The renin-angiotensin-aldosterone system (RAAS) plays a dominant role in the pathophysiology of hypertension, Diabetes mellitus (DM), chronic kidney disease (CKD) and chronic heart failure (CHF). Therefore, drugs that block key components of the RAAS such as ACE inhibitors (ACEi) and angiotensin receptor blockers (ARBs) have gained wide clinical use for these indications. Despite progress, the morbidity and mortality of patients treated with ACEi or ARBs remain high. Small molecules that directly inhibit renin…

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