The beneficial effects of resveratrol on steatosis and mitochondrial oxidative stress in HepG2 cells

Izdebska, Magdalena; Piątkowska‐Chmiel, Iwona; Korolczuk, Agnieszka; Herbet, Mariola; Gawrońska‐Grzywacz, Monika; Gieroba, Renata; Sysa, Marcin; Czajkowska-Bania, Klaudia; Cygal, Marcelina; Korga, Agnieszka; Dudka, Jarosław

doi:10.1139/cjpp-2016-0561

Cited by 33 publications

(26 citation statements)

References 27 publications

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“…Studies have shown that resveratrol has a wide range of effects, including antimicrobial , anti‐inflammatory , antiapoptotic , and anticancer effects, and promotes osteogenic factor formation . Resveratrol can also play a beneficial role in liver diseases and hepatic steatosis by reducing oxidative stress and hepatic fibrosis . In addition, resveratrol has antioxidant effects on certain chronic diseases such as diabetes and cardiovascular disease .…”

Section: Introductionmentioning

confidence: 99%

Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Zhao

Song

Zhang

et al. 2018

Obesity

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Objective: Few studies have considered the effect of resveratrol on blood lipid levels, and the results of these studies are inconsistent. In this study, the first meta-analysis on the effect of resveratrol on blood lipid levels in patients with type 2 diabetes was conducted. Methods: This study used keywords such as type 2 diabetes, total cholesterol, triglyceride (TG), high-density lipoprotein, low-density lipoprotein, and resveratrol and their abbreviations, free words, and related words to search PubMed, Cochrane Library, and Embase. The Cochrane risk of bias tool was used to evaluate the risk of bias, and Review Manager 5.3 and Stata 13.0 were used for data merging and statistical analysis. Results: Ten randomized controlled trials involving a total of 363 patients with type 2 diabetes were included in the analysis. The results show that longer resveratrol intervention time (≥6 months) can reduce TG levels. But resveratrol increased total cholesterol in patients within obesity range. In type 2 diabetes patients with obesity and in those who took lipid-lowering drugs, resveratrol increased low-density lipoprotein levels. Conclusions: Resveratrol can improve TG in patients with type 2 diabetes.

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Section: Introductionmentioning

confidence: 99%

Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Zhao

Song

Zhang

et al. 2018

Obesity

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“…Our earlier studies showed that resveratrol decreased steatosis in HepG2 cells induced by fatty acids mixtures and reduced the mitochondrial oxidative stress in cells. We also observed the favorable effect of resveratrol on the mitochondrial membrane potential in HepG2 cells treated with the mixtures of fatty acids (34).…”

Section: Discussionmentioning

confidence: 53%

Resveratrol Limits Lipogenesis and Enhance Mitochondrial Activity in HepG2 Cells

et al. 2018

Self Cite

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Purpose: The aim of this study was to evaluate the effect of resveratrol on de novo lipogenesis in HepG2 cells caused by high glucose concentrations. Increased lipogenesis in the liver is the main reason for the development of nonalcoholic fatty liver disease (NAFLD) - currently one of the most common chronic liver diseases. In developed countries, this disease is mostly associated with nutritional disorders, resulting from the increasing consumption of monosaccharides. Resveratrol is a natural polyphenol with a promising potential for NAFLD treatment. Methods: The steatosis of HepG2 cells was visualized using the intracellular lipid staining by Nile Red dye with a fluorescence microscope. This study also evaluated the effect of resveratrol on the mitochondrial activity (MitoTracker Green staining), dsDNA (Hoechst 33342 staining) and the viability of HepG2 cells treated with high glucose concentrations (25 and 33 mM). Results: Current study showed that high glucose concentrations induced fat-overloading in HepG2 cells (microvacuolar steatosis occurred in most of the cells). Resveratrol (20 μM) limits the steatosis induction in HepG2 cells by glucose and increased the mitochondrial activity of cells. Resveratrol did not affect the viability of HepG2 cells. Conclusion: This beneficial effect could be helpful in the treatment of NAFLD.

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“…In addition, the levels of antioxidant enzyme activity in the liver, such as SOD, GSH-Px, and CAT, are the indices of the antioxidative stress response [26]. Many natural products, such as Asiatic acid, apigenin, and resveratrol, can improve NAFLD by alleviating oxidative stress [27][28][29].…”

Section: Resultsmentioning

confidence: 99%

Preventive Effects of Total Flavonoid C-Glycosides from Abrus mollis on Nonalcoholic Fatty Liver Disease through Activating the PPARα Signaling Pathway

Niu

Chen

et al. 2019

Planta Med

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Abrus pulchellus subsp. mollis (Hance) Verdc. (Leguminosae) is a well-known edible plant usually added to soups and beverages. In this study, vicenin-2 (1), isoschaftoside (2), schaftoside (3), and their enrichment fraction, total flavonoid C-glycosides, derived from the extracts of A. mollis, were firstly found to prevent nonalcoholic fatty liver disease both in vitro and in vivo. In the in vitro study, total flavonoid C-glycosides decreased the lipid accumulation in oleic acid-treated HepG2 cells. The mechanisms of total flavonoid C-glycosides are involved in the regulation of peroxisome proliferator-activated receptor α and its downstream, and the reduction of proinflammatory cytokines. In high-fat diet-induced fatty liver rats, total flavonoid C-glycosides decreased the levels of glutamic-oxalacetic transaminease and glutamic-pyruvic transaminase, and decreased the lipid accumulation both in the liver and blood without affecting food intake. In addition, total flavonoid C-glycosides also increased the activities of the antioxidant enzyme system in vivo. In conclusion, total flavonoid C-glycosides are active components of A. mollis on nonalcoholic fatty liver disease, and can be used in functional food and supplements for nonalcoholic fatty liver disease prevention and treatment.

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The beneficial effects of resveratrol on steatosis and mitochondrial oxidative stress in HepG2 cells

Cited by 33 publications

References 27 publications

Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Resveratrol Limits Lipogenesis and Enhance Mitochondrial Activity in HepG2 Cells

Preventive Effects of Total Flavonoid C-Glycosides from Abrus mollis on Nonalcoholic Fatty Liver Disease through Activating the PPARα Signaling Pathway

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