The Beneficial Effects of <i>Lippia Citriodora</i> Extract on Diet‐Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition

Diez-Echave, Patrícia; Vezza, Teresa; Rodríguez-Nogales, Alba; Hidalgo-García, Laura; Garrido-Mesa, José; Ruiz-Malagón, Antonio Jesús; Molina-Tijeras, José Alberto; Romero, Miguel; Robles-Vera, Iñaki; Leyva-Jiménez, Francisco Javier; Lozano‐Sánchez, Jesús; Arráez‐Román, David; Segura‐Carretero, Antonio; Micol, Vicente; García, Féderico; Morón, Rocío; Duarte, Juan; Rodríguez-Cabezas, Maria Elena; Gálvez, Júlio

doi:10.1002/mnfr.202000005

Cited by 20 publications

(15 citation statements)

References 42 publications

(49 reference statements)

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“…Lemon verbena ( Aloysia citriodora Paláu) ethanolic extracts contain polyphenols, iridoids, and flavonoids that contribute to their biological effects. In a study with HFD-fed mice, a lemon verbena ethanolic extract reduced intestinal dysbiosis, decreased the Firmicutes/Bacteroidetes ratio, and increased Akkermansia abundance in comparison with untreated HFD-fed mice [ 62 ]. The biological activities of rosemary ( Salvia rosmarinus Spenn.)…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

et al. 2022

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Background: Various neurocognitive and mental health-related conditions have been associated with the gut microbiome, implicating a microbiome–gut–brain axis (MGBA). The aim of this systematic review was to identify, categorize, and review clinical evidence supporting medicinal plants for the treatment of mental disorders and studies on their interactions with the gut microbiota. Methods: This review included medicinal plants for which clinical studies on depression, sleeping disorders, anxiety, or cognitive dysfunction as well as scientific evidence of interaction with the gut microbiome were available. The studies were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Eighty-five studies met the inclusion criteria and covered thirty mental health-related medicinal plants with data on interaction with the gut microbiome. Conclusion: Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways. However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites. Data for Panax ginseng, Schisandra chinensis, and Salvia rosmarinus indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits. Studies specifically assessing the effects on MGBA-related pathways are still required for most medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

et al. 2022

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“…All data presented herein were obtained from refs. [44,54,55,70,72,74,75,78,88,95,96,98,102–111,116,119–121,124–130,132,134–137,140–144,147–156,158,159,161,163–171,173–176...…”

Section: Diet Composition and Exposure Timementioning

confidence: 99%

Modeling Diet‐Induced Metabolic Syndrome in Rodents

Leonardi

Gosmann

Zimmer

2020

Molecular Nutrition Food Res

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Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.

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“…For this reason, there is a clear interest in the development of alternative and/or complementary strategies that combine efficacy and safety for preventing and/or treating obesity. Among these, plant extracts containing different active compounds, like polyphenols, can play a prominent role, given their antioxidant activity, ability to improve insulin resistance and modulate the obesity-associated inflammatory response, as well as to preserve the altered intestinal barrier function and restore gut dysbiosis [ 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice

et al. 2022

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Nowadays, there is an increasing interest in alternative therapies in the treatment of metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice. The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty acid producing bacteria, which have been associated with the maintenance of gut permeability and weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These effects may be mediated by modulation of the gut microbiota.

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The Beneficial Effects of Lippia Citriodora Extract on Diet‐Induced Obesity in Mice Are Associated with Modulation in the Gut Microbiota Composition

Cited by 20 publications

References 42 publications

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Modeling Diet‐Induced Metabolic Syndrome in Rodents

The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice

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