The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential

Andrews, David W.; Brahmbhatt, Hetal; Leber, Blanka

doi:10.1016/b978-0-12-394447-4.30051-7

Encyclopedia of Cell Biology 2016

DOI: 10.1016/b978-0-12-394447-4.30051-7

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The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential

David W. Andrews

Hetal Brahmbhatt

Blanka Leber

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2018

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“…Membrane proteins regulate various cellular activities and play vital roles in every living cell. − Determining the dynamic behavior of membrane proteins is key to understanding their biological functions . In past decades, various techniques have been used to study protein–membrane interactions and have made significant progress, including techniques such as nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy, for example.…”

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Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers

Liu

et al. 2018

Biochemistry

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It is challenging to assess protein-membrane interactions because of the lack of appropriate tools to detect position changes of single proteins in the ∼4 nm range of biological membranes. We developed an assay recently, termed surface-induced fluorescence attenuation (SIFA). It is able to track both vertical and lateral dynamic motion of singly labeled membrane proteins in supported lipid bilayers. Similar to the FRET (fluorescence resonance energy transfer) principle, SIFA takes advantage of the energy transfer from a fluorophore to a light-absorbing surface to determine the distance at 2-8 nm away from the surface. By labeling a protein with a proper fluorophore and using graphene oxide as a two-dimensional quencher, we showed that SIFA is capable of monitoring three-dimensional movements of the fluorophore-labeled protein not only inside but also above the lipid bilayer atop the graphene oxide. Our data show that SIFA is a well-suited method to study the interplay between proteins and membranes.

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confidence: 99%

Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers

Liu

et al. 2018

Biochemistry

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The Bcl-2 Family Proteins: Insights into Their Mechanism of Action and Therapeutic Potential

Cited by 1 publication

References 126 publications

Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers

Watching Three-Dimensional Movements of Single Membrane Proteins in Lipid Bilayers

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