The Basal-Cell Nevus

Howell, J. B.

doi:10.1001/archderm.1959.01560130069008

Cited by 164 publications

(10 citation statements)

References 5 publications

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“…A relationship between multiple basal cell carcinomas and developmental defects was suggested by Binkley and Johnson in 1951 [1] and Howell and Caro in 1959 [2], but it was Gorlin and Goltz who, in 1960, first described a distinct syndrome consisting of the presence of multiple nevoid basal cell epitheliomas, jaw cysts, and bifid ribs [3]. Nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin syndrome, is a rare condition, with an estimated prevalence of 1 per 40–57,000 [4], though the figure may be higher [5].…”

Section: Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome)mentioning

confidence: 99%

Hereditary Genodermatoses with Cancer Predisposition

Gerstenblith

Goldstein

Tucker

2010

Hematology/Oncology Clinics of North America

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Synopsis Hereditary genodermatoses with cancer predisposition are reviewed, including Nevoid Basal Cell Carcinoma Syndrome, Neurofibromatosis Types 1 and 2, Tuberous Sclerosis Complex, Xeroderma Pigmentosum, and Dyskeratosis Congenita. Hereditary melanoma is also included, though it differs from the others in several respects. The underlying genetic aberrations causing these syndromes are largely known, allowing novel treatments to be developed for some of these disorders. Early recognition and diagnosis allows for close follow-up and surveillance for associated malignancies.

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Section: Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome)mentioning

confidence: 99%

Hereditary Genodermatoses with Cancer Predisposition

Gerstenblith

Goldstein

Tucker

2010

Hematology/Oncology Clinics of North America

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“…This and other syndromes with trichoepitheliomas have already been discussed. TPM must also be differentiated clinically from other hereditary and nonhereditary disorders, including adenoma sebaceum of tuberous sclerosis, multiple syringomas, the basal cell nevus syndrome, and rare syndromes of multiple pilar hamartomas (44, [55][56][57][58][59][60]. Confirmation of the diagnosis is usually histologic.…”

Section: Clinical Differential Diagnosismentioning

confidence: 99%

Trichoepithelioma Papulosum Multiplex

Centurion

Schwartz

Lambert

2000

The Journal of Dermatology

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Trichoepithelioma papulosum multiplex is an uncommon autosomal dominant disorder in which multiple trichoepitheliomas are seen. Its cause may be a defective tumor suppressor gene. Studies have mapped this gene to the 9p21 locus. However, there is a parallel or identical syndrome of multiple trichoepitheliomas and cylindromas. Within a given family, some members may have cyclindromas whereas others may have trichoepitheliomas or a combination of both. Although preliminary evidence suggests a different gene is responsible, it is possible that TPM may be caused by more than two independent genes, with some cases of TPM due to impairment of the gene for cylindromatosis. This entity, as well as other disorders with multiple appendageal tumors, may require clarification and distinction from TPM.

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“…He noted, however, that true nevocellular cells were not present and con sidered the majority of the lesions to be quiescent basal cell nevi from which frank epitheliomas could develop. Others also al luded to the hamartomalous nature of these tumors which ultimately may become inva sive [2][3][4][5][6]. Recent attention has focused pri marily on those tumors which have become more aggressive [7,8].…”

Section: Discussionmentioning

confidence: 99%