Yifat Glucksam-Galnoy, Roy Sananes, Nava Silberstein, Pnina Krief, Vladimir V. Kravchenko, Michael M. Meijler, Tsaffrir Zor
The bacterial N-3-oxo-dodecanoyl-L-homoserine lactone (C12) has critical roles in both inter-bacterial communication and inter-kingdom signaling. The ability of C12 to down-regulate production of the key pro-inflammatory cytokine tumor necrosis factor α (TNFα) in stimulated macrophages was suggested to contribute to the establishment of chronic infections by opportunistic Gram-negative bacteria, such as Pseudomonas aeruginosa. We show that in contrast to TNFα suppression, C12 amplifies production of the major…
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