The Bacterial Microbiome and Virome Milestones of Infant Development

Lim, Efrem S.; Wang, David; Holtz, Lori R.

doi:10.1016/j.tim.2016.06.001

Cited by 109 publications

(103 citation statements)

References 84 publications

(134 reference statements)

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“…Previous studies also detected a relatively low percentage of children with PBVs (67,68). This therefore adds up to the notion that PBVs are likely to be absent in infants and young children and only start to increase with age and potentially a changing diet, though this needs to be further proven (69,70). Interestingly, the genetic relatedness of a human picobirna-like virus with one that was found in a bat pool from the same region suggests an interspecies transmission.…”

Section: Listeria~phage~vb_lmos_293mentioning

confidence: 86%

Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses

Yinda

Vanhulle

Conceição-Neto

et al. 2019

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Despite the availability of diagnostic tools for different enteric viral pathogens, a large fraction of human cases of gastroenteritis remains unexplained. This could be due to pathogens not tested for or novel divergent viruses of potential animal origin. Fecal virome analyses of Cameroonians showed a very diverse group of viruses, some of which are genetically related to those identified in animals. This is the first attempt to describe the gut virome of humans from Cameroon. Therefore, the data represent a baseline for future studies on enteric viral pathogens in this area and contribute to our knowledge of the world’s virome. The studies also highlight the fact that more viruses may be associated with diarrhea than the typical known ones. Hence, it provides meaningful epidemiological information on diarrhea-related viruses in this area.

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Section: Listeria~phage~vb_lmos_293mentioning

confidence: 86%

Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses

Yinda

Vanhulle

Conceição-Neto

et al. 2019

mSphere

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“…Contrary to previous assumptions of a ‘sterile womb’ paradigm, in which the acquisition of bacteria first occurs at birth, recent evidence suggests that the first interactions between the microbiota and the host may be initiated in utero . Any microbial presence in utero was assumed to be a danger for the foetus and intra‐uterine infection may indeed cause preterm delivery .…”

Section: The First Microbial Encountersmentioning

confidence: 87%

“…Direct presentation of maternal bacterial components to the foetus has been recognized as a potential route for immune imprinting , as a way to prepare the neonatal immune system to respond appropriately to the much larger inoculum transferred during vaginal delivery and breastfeeding . In line with this suggestion, exposure of germ‐free mice to bacteria only during pregnancy increased the numbers of monocytes and group 3 innate lymphoid cells in the intestinal mucosa of the offspring .…”

Section: Do Prenatal Microbial Exposures Affect Immune Programming?mentioning

confidence: 94%

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The mother–offspring dyad: microbial transmission, immune interactions and allergy development

Jenmalm

2017

J Intern Med

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“…In sum, HMOs select for the growth of both HMO-metabolizing Bifidobacterium species and mucin-metabolizing Bacteroides species (Table 2). 36–38 …”

Section: Impact Of the Human Milk Glycobiome On Symbiotic Bacteriamentioning

confidence: 99%

The Human Milk Glycome as a Defense Against Infectious Diseases: Rationale, Challenges, and Opportunities

Craft

Townsend

2017

ACS Infect. Dis.

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Each year over 3 million people die from infectious diseases with most of these deaths being poor and young children who live in low- and middle-income countries. Infectious diseases emerge for a multitude of reasons. On the social front, reasons include a breakdown of public health standards, international travel, and immigration (for financial, civil, and social reasons). At the molecular level, the modern rise of infectious diseases is tied to the juxtaposition of drug-resistant pathogens and a lack of new antimicrobials. The consequence is the possibility that humankind will return to the preantibiotic era wherein millions of people will perish from what should be trivial illnesses. Given the stakes, it is imperative that the chemistry community take leadership in delivering new antibiotic leads for clinical development. We believe this can happen through innovation in two areas. First is the development of novel chemical scaffolds to treat infections caused by multidrug-resistant pathogens. The second area, which is not exclusive to the first, is the generation of antibiotics that do not cause collateral damage to the host or the host’s microbiome. Both can be enabled through advances in chemical synthesis. It is with this general philosophy in mind that we hypothesized human milk oligosaccharides (HMOs) could serve as novel chemical scaffolds for antibacterial development. We provide herein a personal account of our laboratory’s progress toward the goal of using HMOs as a defense against infectious diseases.

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The Bacterial Microbiome and Virome Milestones of Infant Development

Cited by 109 publications

References 84 publications

Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses

Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses

The mother–offspring dyad: microbial transmission, immune interactions and allergy development

The Human Milk Glycome as a Defense Against Infectious Diseases: Rationale, Challenges, and Opportunities

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