The Bacillus cereus Group

Ramarao, Nalini; Lereclus, Didier; Sorokin, Alexeï

doi:10.1016/b978-0-12-397169-2.00059-7

Cited by 11 publications

(6 citation statements)

References 362 publications

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“…Bacillus cereus group species are sporulating ubiquitous bacteria that form biofilms. These properties allow them to withstand most cleaning and decontamination processes (Ramarao et al, 2015). It is not surprising to find them at all food processing steps and in different hospital environments.…”

Section: Introductionmentioning

confidence: 99%

The cytotoxic potential of Bacillus cereus strains of various origins

et al. 2021

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Section: Introductionmentioning

confidence: 99%

The cytotoxic potential of Bacillus cereus strains of various origins

et al. 2021

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“…The Bacillus cereus group is composed of rod-shaped, spore-forming, aerobic or facultative anaerobic species [9], among which the most noticeable members are species from B. cereus sensu stricto (usually referred to as B. cereus), B. mycoides, B. pseudomycoides, B. weihenstephanensis, B. anthracis, B. thuringiensis, B. cytotoxicus and B. toyonensis. The genetic proximity of the species within the B. cereus group has not permitted their distinction from a phylogenetic point of view; nevertheless, species can be differentiated through phenotypic characteristics, host species predilection and clinical manifestation [10,11].…”

Section: Introductionmentioning

confidence: 99%

Structural Modeling of Cell Wall Peptidase CwpFM (EntFM) Reveals Distinct Intrinsically Disordered Extensions Specific to Pathogenic Bacillus cereus Strains

Tran

Cormontagne

Vidić

et al. 2020

Toxins

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The emergence of B. cereus as an opportunistic food-borne pathogen has intensified the need to distinguish strains of public health concern. The heterogeneity of the diseases associated with B. cereus infections emphasizes the versatility of these bacteria strains to colonize their host. Nevertheless, the molecular basis of these differences remains unclear. Several toxins are involved in virulence, particularly in gastrointestinal disorders, but there are currently no biological markers able to differentiate pathogenic from harmless strains. We have previously shown that CwpFM is a cell wall peptidase involved in B. cereus virulence. Here, we report a sequence/structure/function characterization of 39 CwpFM sequences, chosen from a collection of B. cereus with diverse virulence phenotypes, from harmless to highly pathogenic strains. CwpFM is homology-modeled in silico as an exported papain-like endopeptidase, with an N-terminal end composed of three successive bacterial Src Homology 3 domains (SH3b1–3) likely to control protein–protein interactions in signaling pathways, and a C-terminal end that contains a catalytic NLPC_P60 domain primed to form a competent active site. We confirmed in vitro that CwpFM is an endopeptidase with a moderate peptidoglycan hydrolase activity. Remarkably, CwpFMs from pathogenic strains harbor a specific stretch of twenty residues intrinsically disordered, inserted between the SH3b3 and the catalytic NLPC_P60 domain. This strongly suggests this linker as a marker of differentiation between B. cereus strains. We believe that our findings improve our understanding of the pathogenicity of B. cereus while advancing both clinical diagnosis and food safety.

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“…We performed a comparative analysis of the pathogenicity factors of the other consortium member B. paranthracis, which can attack epithelial cells, as well as overcome and/or suppress the host's immune response. Taxonomically, B. paranthracis is very close to Bacillus cereus, a gram-positive sporeforming bacterium that provokes food poisoning and severe opportunistic infections [10,11]. B. cereus is present in soil and in food products; it contaminates human skin and nearly all surfaces in hospital environments.…”

Section: Discussionmentioning

confidence: 99%

Identification and pathogenic (toxicogenic) potential of Staphylococcus haemolyticus and Bacillus paranthracis consortia isolated from bovine mastitis in Russia

Sokolov

Бровко

Solonin

et al. 2023

Preprint

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Bovine mastitis is one of the most economically important diseases in cattle. Infectious mastitis has a viral or bacterial origin. The most common bacterial agents are Staphylococcus, Streptococcus, coliforms, and Bacillus species. These are opportunistic microorganisms that can switch to a pathogenic form, using various virulence factors with follow various pathologies, both animal and human. Three stable microbial consortia, each composed of Bacillus paranthracis and Staphylococcus haemolyticus strains, were isolated from milk of cows diagnosed with mastitis in three geographically remote regions of Russia. The composition of these consortia remained stable following multiple passages on culture media. Apparently, this stability is due to the structure of the microbial biofilms formed by the communities. The virulence of the consortia depended on the B. paranthracis strains. It seems plausible that the ability of the consortia to cause mastitis in cattle was affected by mutations of the cytK gene of B. paranthracis.

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The Bacillus cereus Group

Cited by 11 publications

References 362 publications

The cytotoxic potential of Bacillus cereus strains of various origins

The cytotoxic potential of Bacillus cereus strains of various origins

Structural Modeling of Cell Wall Peptidase CwpFM (EntFM) Reveals Distinct Intrinsically Disordered Extensions Specific to Pathogenic Bacillus cereus Strains

Identification and pathogenic (toxicogenic) potential of Staphylococcus haemolyticus and Bacillus paranthracis consortia isolated from bovine mastitis in Russia

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