The Axin2 rs2240308 polymorphism and susceptibility to lung cancer in a Chinese population

Abstract

Axis inhibition protein 2 (Axin2) is a negative regulator of the canonical Wnt/β-catenin signaling pathway, and functions as a tumor suppressor in a number of human cancers. Previous pilot studies have suggested an association between Axin2 exon1 148 (rs2240308) SNP polymorphism and risk for lung cancer. In the present study, we aimed to investigate the Axin2 exon1 148 polymorphism and its association with lung cancer susceptibility in Han Chinese population. The Axin2 exon1 148 SNP was genotyped in 555 controls and 520 lung cancer patients using TaqMan SNP Genotyping Assays. Unconditional logistic regression analysis was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). We observed that the genotype frequencies of TC, TT, and CC were significantly different between controls and cases (χ(2) = 6.849, P = 0.03256, df = 2). Subjects carrying T allele (TC + TT genotypes) had decreased susceptibility to lung cancer as compared to those carrying CC genotype (OR = 0.733, 95% CI = 0.5726-0.9393, P = 0.01382). No significant association was found between rs2240308 polymorphism and histological subtypes of lung cancers. Findings from this study suggest that Axin2 exon1 T148C polymorphism (rs2240308) contributes to increased susceptibility to lung cancer in Chinese population. This further implicates Axin2 as a lung cancer-related gene.

Association study between genetic variations inAxin2gene and lung cancer risk in North Indian population: A multiple interaction analysis

“…21 It was keen to observe a protective effect in subjects who carried the variant (TT) genotype for Axin2 148 C > T (p = 0.01). Many studies have evidently reported the same 20 The similar results have been reported in Chinese 23 and Japanese lung cancer patients. 21 Also, similar reports are available in case of other type of cancers including breast, 33 prostate, 24 astrocytoma, 25 and ovarian.…”

Molecular regulation and pharmacological targeting of the β‐catenin destruction complex

“…Thus, this diminished sensitivity of axin2 for inhibition by upstream signalling provides an elegant explanation for the effective restoration of destruction complex activity by axin2 (Bernkopf et al, ). The importance of axin2‐mediated feedback is further illustrated by the clear association between axin2 germline variants with increased cancer risk (Liu et al, ; Aristizabal‐Pachon et al, ; Rosales‐Reynoso et al, ; Bahl et al, ) and the occurrence of somatic axin2 frameshift mutations in various types of cancer (Mazzoni and Fearon, ; Li et al, ).…”

AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients

“…However, previous reports on the association between the AXIN2 rs2240308 polymorphism and risk of cancer show inconsistent results. Thus, significant associations were found with lung, prostate, and breast cancer (Gunes et al, 2009;Liu et al, 2014;Ma et al, 2014;Aristizabal-Pachon et al, 2015), but not with astrocytoma , ovarian cancer (Mostowska et al, 2014), head and neck cancer, and CRC (Kanzaki et al, 2006;Naghibalhossaini et al, 2012). Ethnic differences have also been observed in the association between the AXIN2 rs2240308 polymorphism and cancer risk Gong et al, 2015;Wu et al, 2015;Zhong et al, 2015).…”