The autoantibody response to Ro/SSA in cutaneous lupus erythematosus

Lee, L. A.

doi:10.1001/archderm.130.10.1262

Cited by 34 publications

(29 citation statements)

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“…20 The lowest levels of anti-Ro52 was found in patients with CCLE, results similar to those of Lee et al 21 but we could not confirm the findings of isolated La-reactivity as a predisposing factor for CLE. 22 Patients with CCLE are most commonly seronegative, and our patients were selected based on Ro/SSA positivity in routine clinical testing and thus represent a group of patients more close to the SCLE/SLE group.…”

Section: Discussioncontrasting

confidence: 71%

Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun

Popovic

Brauner²,

Ek³

et al. 2007

Lupus

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Anti-Ro/SSA assays assist the clinician in distinguishing autoimmune diseases such as Sjögrenś syndrome (SS), systemic lupus erythematosus (SLE) and subacute cutaneous lupus erythematosus (SCLE). The objective of the study was to investigate the fine specificity of the autoantibodies in relation to clinical presentation as well as environmental and endogenous factors such as photosensitivity, smoking and immunoglobulin (Ig) levels in patients with Ro/SSA autoantibodies. Serum samples from 96 anti-Ro/SSA positive photosensitive patients were tested for autoantibody levels by enzyme-linked immunosorbent assay (ELISA) using purified recombinant Ro52 kd, Ro60 kd and La proteins as antigens. The highest levels of anti-Ro52 and anti-La were observed in patients with primary SS, and the lowest levels of anti-Ro52 in chronic cutaneous lupus erythematosus (CCLE). SCLE patients with systemic disease (SLE and/or SS) showed higher levels of anti-Ro52 than SCLE limited to the skin. A correlation between high serum levels of IgG and anti-Ro52 (P < 0.01) and between IgA and anti-Ro52 (P < 0.05) and anti-Ro60 (P < 0.05) was found. Polymorphic light eruption (PLE) was common in all diagnostic groups but did not correlate with autoantibody levels. Smoking was more common in lupus patients than in SS patients. Our findings thus propose different mechanisms for different clinical presentations of Ro/SSA positive patients. The testing of anti-Ro52 antibodies might serve as a prognostic tool in photosensitive cutaneous diseases.

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Section: Discussioncontrasting

confidence: 71%

Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun

Popovic

Brauner²,

Ek³

et al. 2007

Lupus

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“…Anti-Ro/SSA antibodies were present in 71% of our patients like in most papers [8, 11, 15]. Different prevalence rates (80% [16]and 28% [10]) have been reported, however.…”

Section: Discussionsupporting

confidence: 51%

Clinical, Histological and Immunopathological Features of 58 Patients with Subacute Cutaneous Lupus erythematosus

et al. 2000

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Background: Subacute cutaneous lupus erythematosus (SCLE) is a distinct subset of cutaneous lupus erythematosus clinically characterized by psoriasiform and/or annular lesions and by a mild or absent systemic involvement. Objective: The Italian Group of Immunodermatology of the Italian Society of Dermatology and Venereology reviewed the cases of SCLE seen in 10 years (1987–1996). Patients: Forty-six women and 12 men have been retrospectively studied, 42% had annular lesions, 39% psoriasiform ones and 16% both. Results: Lesions were mainly localized on the neck and face and relapsed in spring and autumn. Seventeen patients had 4 or more American College of Rheumatology criteria and could be classified as having systemic lupus erythematosus. The most frequent histopathological alterations were epidermal atrophy, hydropic degeneration of the basal layer and perivascular lymphocytic infiltrate. Deposits of immunoglobulins and C3 at the dermo-epidermal junction on the clinically involved skin were present in 86% of the patients. Dust-like particles in the epidermis were only found in 3% of cases. Anti-Ro/SSA antibodies were found in 71% of the cases and anti-dsDNA only in 5% of cases. Conclusions: SCLE is a particular subset of cutaneous lupus erythematosus with peculiar clinical and immunopathological features.

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“…One study done looked the results of serologic analysis of 32 patients (17 SCLE, 15 DLE) using different assays and isoforms of Ro/SSA antibody and found that all SCLE patients were positive for Ro/SSA-60kd on immunodiffusion compared with 7% (1/15) of DLE patients (Lee et al, 1994). Only 71% (12/17) of SCLE patients were positive for Ro/SSA-60kd on immunoblotting, which the authors attributed to loss of epitope binding site after protein denaturing (Lee et al, 1994).…”

Section: Serological Characteristics Of Dlementioning

confidence: 99%

Classifying discoid lupus erythematosus: background, gaps, and difficulties

Haber

Merola

Werth

2017

International Journal of Women's Dermatology

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To inform our ongoing efforts to develop defining features to be incorporated into a novel set of classification criteria for discoid lupus erythematosus (DLE), we conducted a literature review using the Ovid MEDLINE database. A search was performed to identify studies reporting criteria used to distinguish DLE from other cutaneous lupus erythematosus subtypes. We examined which clinical, histopathologic, and serologic features have data to support their use as effective features in distinguishing DLE from other potential disease mimickers and cutaneous lupus subsets. Through our search, we were also able to identify gaps that exist in the literature which can inform future directions for research endeavors. We found that localization of lesions, characteristic features of damage, and the absence of high titer Ro/SSA antibody seem most effective in differentiating DLE from other cutaneous lupus erythematosus subtypes. Histopathologic features and class of immunoreactant deposition appear to be less helpful.

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The autoantibody response to Ro/SSA in cutaneous lupus erythematosus

Cited by 34 publications

References 0 publications

Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun

Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun

Clinical, Histological and Immunopathological Features of 58 Patients with Subacute Cutaneous Lupus erythematosus

Classifying discoid lupus erythematosus: background, gaps, and difficulties

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