The associations between organophosphate esters and urinary incontinence in the general US population

He, Meiling; Jin, Kun; Qiu, Shi; Liao, Xinyang; Zheng, Xiaonan; Chen, Zeyu; Ai, Jianzhong; Yang, Lu; Jiang, Zhongyuan; Hu, Dan; Wei, Qiang

doi:10.1007/s11356-021-14153-5

Cited by 4 publications

(5 citation statements)

References 30 publications

(36 reference statements)

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“…A recent analysis of the NHANES database by He et al (15) found that urine metabolites of OPEs were linked to a higher odds ratio for mixed incontinence in females. Nonetheless, the precise mechanism by which OPEs impact bladder function remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Then 0.2 mL of the subject's urine was used for enzymatic hydrolysis of urinary conjugates of the target analytes, automated off-line solid phase extraction, reversed phase high-performance liquid chromatography separation, and isotope dilution-electrospray ionization tandem mass spectrometry detection (29). We included four major OPE urine metabolites in this study (15): Diphenyl phosphate(DPHP), Bis(1,3-dichloro-2propyl)phosphate(BDCPP), Bis(2-chloroethyl) phosphate(BCEP), and Dibutyl phosphate(DBUP). According to the NHANES Analytic Guidelines, if the detection results of urine metabolites were below the limit of detection, the values were imputed by the square root of two.…”

Section: Urine Opes Metabolites Assessmentmentioning

confidence: 99%

“…It is noteworthy that some halogenated OPEs are carcinogenic to animals (12). Furthermore, studies indicate that OPEs increase the risk of cardiovascular disease, metabolic syndrome, urinary incontinence, and non-alcoholic fatty liver disease in adults (13)(14)(15)(16). Meanwhile, in adolescents, it can also cause disorders of glucose metabolism, induce pre-diabetes, and lead to hypertension (17,18).…”

Section: Introductionmentioning

confidence: 99%

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Associations between exposure to organophosphate esters and overactive bladder in U.S. adults: a cross-sectional study

Lin,

Wang,

et al. 2023

Front. Public Health

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BackgroundThe relationship between exposure to organophosphate esters (OPEs) and the risk of developing overactive bladder (OAB) is uncertain. The purpose of this study is to examine the potential link between urinary metabolites of organophosphate esters and OAB.MethodData from the National Health and Nutrition Examination Survey (NHANES) database of the 2011–2016 cycles were utilized. Four urinary metabolites of organophosphate esters: diphenyl phosphate (DPHP), bis (1,3-dichloro-2-propyl) phosphate (BDCPP), bis (2-chloroethyl) phosphate (BCEP), and dibutyl phosphate (DBUP) were included in the study. Multivariate logistic regression and restricted cubic spline (RCS) were used to evaluate the relationship between urinary OPEs metabolites and OAB. Interaction analysis was conducted on subgroups to confirm the findings.ResultsA total of 3,443 United States (US) adults aged 20 years or older were included in the study, of whom 597 participants were considered to have OAB. After adjusting for potential confounding factors, we found a positive association between DPHP and the risk of overactive bladder. The risk of overactive bladder increased with increasing DPHP concentrations compared with quartile 1 (quartile 2, OR = 1.19, 95% CI, 0.82–1.73, P = 0.34; quartile 3, OR = 1.67, 95% CI, 1.10–2.53, P = 0.02; Q4, OR = 1.75, 95% CI, 1.26–2.43, P = 0.002). However, after dividing the participants by gender, only the female group retained consistent results. Additionally, restricted cubic spline analysis revealed a nonlinear dose-response correlation between DPHP and OAB in female participants. In the subgroup analysis based on age, race, body mass index (BMI), recreational activity, smoking status, drinking status, hypertension, diabetes, and stroke, the interaction analysis revealed that the findings were uniform.ConclusionOur findings indicate that exposure to DPHP could elevate the risk of OAB in US adult females. Further experimental studies are needed to explore the underlying mechanism in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Urine Opes Metabolites Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between exposure to organophosphate esters and overactive bladder in U.S. adults: a cross-sectional study

Lin,

Wang,

et al. 2023

Front. Public Health

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“…Several potential confounders were controlled for in the statistical model: age (years), sex (male or female), body mass index (BMI), race/ethnicity (Mexican American, Other Hispanic, non-Hispanic White, non-Hispanic Black, and Other race), poverty income ratio (PIR), family history of asthma (yes or no), serum cotinine (a biomarker of exposure to environmental tobacco smoke), and urinary creatinine. PIR was divided into three groups: ≤ 1.3, 1.3 to 3.5, ≥ 3.5, which representing low, medium, and high levels respectively (He et al 2022). For children in the same sex and age group, underweight/normal weight, overweight and obesity were de ned as BMI percentile < 85, 85 ≤ BMI percentile ≤ 95, BMI percentile > 95, respectively (Krebs et al 2007).…”

Section: Covariatesmentioning

confidence: 99%

Association between environmental pyrethroid exposure and asthma among U.S. children and adults in National Health and Nutrition Examination Survey (2007–2014)

Guo

Wang

et al. 2022

Preprint

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Objectives: The evidence interpreting the association between environmental pyrethroid exposure and asthma is limited. The objective of this study was to examine the association between pyrethroid exposure and asthma among U.S. children and adults. Methods: Participants were collected from the National Health and Nutrition Examination Survey (NHANES, 2007-2014), including children and adults. 3-phenoxybenzoic acid (3-PBA) was used as a biomarker for pyrethroid metabolites. Multiple logistic regression models were constructed to estimate the association of urinary 3-PBA with asthma among children and adults and to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Additionally, a restricted cubic spline plot with three knots was applied to assess the potential nonlinear relationship between pyrethroid exposure and asthma.Results: Collectively, 7,776 participants were enrolled, including 2,236 children and 5,540 adults. The weighted prevalence of asthma in children and adults was 12.23% and 8.66% respectively. After adjusting for age, sex, race/ethnicity, poverty income ratio (PIR), body mass index (BMI), serum cotinine, urinary creatinine and family history of asthma, our results indicated that higher levels of 3-PBA was positively related to the risk of asthma among children (OR: 1.395; 95%CI: 0.880, 2.210) and adults (OR: 1.177; 95%CI: 0.778, 1.781). This positive association seemed to be more pronounced among 12-19-years old children and girls. Furthermore, the restricted cubic spline plot showed a linear relationship between levels of 3-PBA and asthma among children and adults (p for nonlinearity was 0.693 and 0.691 respectively).Conclusions: Our study observed a positive association between 3-PBA and asthma among children and adults while this positive association was more pronounced among children. However, we can not role out the possibility that the possible role of other co-occurring pesticides and other chemicals in the observed trends in asthma incidence. Therefore, further studies are needed to evaluate the possible pathogenic role of pyrethroid insecticides in asthma.

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“…This implies that changes in the endocrine state and inflammation can impact pelvic floor tissue structure, leading to urinary dysfunction. Besides, environmental factors, such as organophosphate esters with known endocrine-disrupting properties, are also linked to structural disruptions in the pelvic floor, contributing to incontinence [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary phenols and parabens exposure in relation to urinary incontinence in the US population

Jiang,

Chen,

Tang

et al. 2024

BMC Public Health

Self Cite

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Background Our study aimed to investigate the impact of urinary concentrations of personal care products (PCPs)-related phenols (PNs) and parabens (PBs), including Triclosan (TCS), Bisphenol A (BPA), Benzophenone-3 (BP-3), Butylparaben (BPB), Ethylparaben (EPB), Methylparaben (MPB), and Propylparaben (PPB), on urinary incontinence (UI) occurrence. Method We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2016. Regression analysis was employed to investigate the relationship between exposure to PCPs-related substances, various levels of exposure, and UI within both the general population and the female demographic. Additionally, the Bayesian Kernel Machine Regression (BKMR) model was used to assess the effects of mixtures on UI. Results Our analysis comprised 7,690 participants who self-reported their diagnosis. Among them, 12.80% experienced stress urinary incontinence (SUI), 11.80% reported urge urinary incontinence (UUI), and 10.22% exhibited mixed urinary incontinence (MUI). In our fully adjusted multivariable models, BP-3 exposure exhibited a positive association with SUI (OR 1.07, 95% CI 1.02–1.14, p = 0.045). BPA exposure correlated with an increased risk of UUI (OR 1.21, 95% CI 1.01–1.44, p = 0.046) and MUI (OR 1.26, 95% CI 1.02–1.54, p = 0.029). TCS exposure displayed a negative correlation with the incidence of MUI (OR 0.87, 95% CI 0.79–0.97, p = 0.009). No significant links were observed between parabens and urinary incontinence. Notably, among the female population, our investigation revealed that BPA exposure heightened the risk of MUI (OR 1.28, 95% CI 1.01–1.63, p = 0.043). Participants in the highest tertile of BP-3 exposure demonstrated elevated likelihoods of SUI and MUI compared to those in the lowest tertile. In the BKMR analysis, negative trends were observed between the mixture and the risks of UUI and MUI when the mixture ranged from the 25th to the 40th and 35th to the 40th percentiles or above, respectively. Additionally, a positive trend was identified between the mixture and MUI when it was in the 40th to 55th percentile. Conclusion In conclusion, our findings suggest that exposure to BPA, TCS, and BP-3 may contribute to the development of urinary incontinence.

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The associations between organophosphate esters and urinary incontinence in the general US population

Cited by 4 publications

References 30 publications

Associations between exposure to organophosphate esters and overactive bladder in U.S. adults: a cross-sectional study

Associations between exposure to organophosphate esters and overactive bladder in U.S. adults: a cross-sectional study

Association between environmental pyrethroid exposure and asthma among U.S. children and adults in National Health and Nutrition Examination Survey (2007–2014)

Urinary phenols and parabens exposure in relation to urinary incontinence in the US population

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