The association of spinal osteoarthritis with lumbar lordosis

Papadakis, Michael; Papadokostakis, George; Kampanis, Nikolaos A.; Sapkas, George; Papadakis, Stamatios A.; Katonis, Pavlos

doi:10.1186/1471-2474-11-1

Cited by 91 publications

(74 citation statements)

References 40 publications

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“…Advantages of this method include illuminating the portion of the foot touching the floor. The CatWalk calculates 25 parameters based on footprints and 10 parameters based on time, and for arthritis studies, footprint intensities and areas are the most commonly reported parameters 11, 26–29 . As an example, mice with CFA-induced ankle arthritis had less regular gait with changes in speed and duty factor 11 .…”

Section: Spatiotemporal Characterizationmentioning

confidence: 99%

Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations

Lakes

Allen

2016

Osteoarthritis and Cartilage

116

110

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Gait analysis is a useful tool to understand behavioral changes in preclinical arthritis models. While observational scoring and spatiotemporal gait parameters are the most widely performed gait analyses in rodents, commercially available systems can now provide quantitative assessments of spatiotemporal patterns. However, inconsistencies remain between testing platforms, and laboratories often select different gait pattern descriptors to report in the literature. Rodent gait can also be described through kinetic and kinematic analyses, but systems to analyze rodent kinetics and kinematics are typically custom made and often require sensitive, custom equipment. While the use of rodent gait analysis rapidly expands, it is important to remember that, while rodent gait analysis is a relatively modern behavioral assay, the study of quadrupedal gait is not new. Nearly all gait parameters are correlated, and a collection of gait parameters is needed to understand a compensatory gait pattern used by the animal. As such, a change in a single gait parameter is unlikely to tell the full biomechanical story; and to effectively use gait analysis, one must consider how multiple different parameters contribute to an altered gait pattern. The goal of this article is to review rodent gait analysis techniques and provide recommendations on how to use these technologies in rodent arthritis models, including discussions on the strengths and limitations of observational scoring, spatiotemporal, kinetic, and kinematic measures. Recognizing rodent gait analysis is an evolving tool, we also provide technical recommendations we hope will improve the utility of these analyses in the future.

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Section: Spatiotemporal Characterizationmentioning

confidence: 99%

Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations

Lakes

Allen

2016

Osteoarthritis and Cartilage

116

110

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“…3,5,[38][39][40][41][42][43] Most researchers agree that the lumbar lordosis angle positively and strongly associated with spondylolysis and isthmic spondylolisthesis. 5,38,[44][45][46][47] Increasing of the lordosis angle is considered as a risk factor for progression of spondylolysis and ventral displacement of the affected vertebra.…”

Section: Discussionmentioning

confidence: 99%

Quantitative evaluation of the lumbosacral sagittal alignment in degenerative lumbar spinal stenosis

Макиров¹,

Yuz²,

Jahaf³

et al. 2015

Int J Spine Surg

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Goal of the study This study intends to develop a method of quantitative sagittal balance parameters assessment, based on a geometrical model of lumbar spine and sacrum. MethodsOne hundred eight patients were divided into 2 groups. In the experimental group have been included 59 patients with lumbar spinal stenosis on L1-5 level. Forty-nine healthy volunteers without history of any lumbar spine pathlogy were included in the control group. All patients have been examined with supine MRI. Lumbar lordosis has been adopted as circular arc and described either anatomical (lumbar lordosis angle), or geometrical (chord length, circle segment height, the central angle, circle radius) parameters. Moreover, 2 sacral parameters have been assessed for all patients: sacral slope and sacral deviation angle. Both parameters characterize sacrum disposition in horizontal and vertical axis respectively. ResultsSignificant correlation was observed between anatomical and geometrical lumbo-sacral parameters. Significant differences between stenosis group and control group were observed in the value of the "central angle" and "sacral deviation" parameters. We propose additional parameters: lumbar coefficient, as ratio of the lordosis angle to the segmental angle (Kl); sacral coefficient, as ratio of the sacral tilt (ST) to the sacral deviation (SD) angle (Ks); and assessment modulus of the mathematical difference between sacral and lumbar coefficients has been used for determining lumbosacral balance (LSB). Statistically significant differences between main and control group have been obtained for all described coefficients (p = 0.006, p = 0.0001, p = 0.0001, accordingly). Median of LSB value of was 0.18 and 0.34 for stenosis and control groups, accordingly. ConclusionBased on these results we believe that that spinal stenosis is associated with an acquired deformity that is measureable by the described parameters. It's possible that spinal stenosis occurs in patients with an LSB of 0.2 or less, so this value can be predictable for its development. It may suggest that spinal stenosis is more likely to occur in patients with the spinal curvature of this type because of abnormal distribution of the spine loads. This fact may have prognostic significance for develop vertebral column disease and evaluation of treatment results.keywords: sagittal lumbosacral balance, lumbar lordosis, lordosis angle, lumbosacral sagittal alignment volume 9 article 68

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“…An abnormal results in the development and progression of lumbar lordosis make spinal osteoarthritis. Degenerative changes in the spine make the loads imposed on the spine distribute abnormally, which will result in the breakdown of the spinal form 12) . This study was intended to examined the relationship between L4-5 HNP and abnormal sagittal spinal alignments; by analysis of the MRIs of an L4-5 HNP patients group and normal adults were analyzed.…”

Section: Discussionmentioning

confidence: 99%

The Correlations between Lumbar Lordosis, L4-5 Disc Angle, L4-5 Disc Height, and the Lumbosacral Angle in L4-5 HNP Patients

Ma¹,

Gong

2010

J Phys Ther Sci

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Abstract. [Purpose] This study was conducted to examine the degree of lumbar lordosis, L 4-5 disc angle, L 4-5 disc height and the lumbosacral angle in L 4-5 herniated nucleus pulposus (HNP) patients and analyze the correlations between these variables to examine the relationship between HNP and abnormal sagittal spinal alignment.[Subjects] The study subjects were 15 lumbar spine 4-5 (L 4-5 ) HNP patients; the control group comprised 15 normal adults. [Methods] Both groups' magnetic resonance imaging scans were compared and analyzed.[Results] The HNP group showed a significantly smaller degree of lumbar lordosis, L 4-5 disc angle, L 4-5 disc height, and lumbosacral angle (p<0.05). I was also shown that as the degree of lumbar lordosis decreased, the disc angle, disc height, and lumbosacral angle decreased.[Conclusion] We found that L 4-5 HNP patients have abnormal sagittal spinal alignments.

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The association of spinal osteoarthritis with lumbar lordosis

Cited by 91 publications

References 40 publications

Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations

Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations

Quantitative evaluation of the lumbosacral sagittal alignment in degenerative lumbar spinal stenosis

The Correlations between Lumbar Lordosis, L4-5 Disc Angle, L4-5 Disc Height, and the Lumbosacral Angle in L4-5 HNP Patients

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